Abstract: The present invention relates to a sustained release oral dosage forms containing a therapeutically effective amount of metoprolol tartrate, methods of preparing such formulations, and to methods of treatment utilizing such formulations.

Abstract: The invention deals with the use of low temperature and low humidity conditions during the storage and shaping of “flash-dose” tablet compositions. The compositions may be rendered substantially non-amorphous before tablet formation.

Abstract: Bioaffecting sachets, or powders, containing coated liquiflash microspheres and partially recrystallized shearform floss particles are disclosed. The sachets give organoleptically acceptable properties, including a pleasing mouthfeel, when orally ingested.

Abstract: The invention relates to compositions useful for making taste-masked oral dosage forms which can be easily processed and which disintegrate rapidly when placed in the mouth. The compositions include coated liquiflash particles and shearform floss particles. Tablets are preferred dosage forms.

Abstract: The thermoforming of compositions containing active agents is carried out by processing compositions containing certain fatty esters in combination.

Abstract: Lipid lowering dosage units, to be used once a day, produce minimal side effects. They contain a combination of microspheres formulated to co-deliver a HMG-CoA reductase inhibitor component and a niacin component.

Abstract: The invention relates to compositions useful for making tablets which can be formed using conventional tableting machines and which disintegrate rapidly in the mouth with optional chewing. The compositions typically include shearform matrices which have been recrystallized using crystallization promoters.

Abstract: A self-binding, glycerine-free tablettable composition has a saccharide carrier and the sugar alcohols sorbitol and xylitol.

Abstract: The invention relates to a novel dosage unit for the sustained-release delivery of active agents as well as compositions and methods for making same.

Abstract: The present invention deals with compositions and methods for preparing comestible units which disperse quickly in the mouth, especially when chewed. The present invention also includes the product made therefrom. The method includes initiating crystallization of shearform matrix with crystallization/bindig promoter and combining it with an additive to form flowable, compactible micro-particulates. The combination is then shaped to form a comestible unit having high structural integrity, good appearance, and excellent release characteristics.

Abstract: Controlled release dosage units containing water soluble active agents can be made using an active agent, an optional inert carrier, a cellulosic polymer and a lipophilic ingredient.

Abstract: Shearform compositions made without added glycerine are disclosed. The compositions are self-binding and exhibit excellent cohesivity when used in tableting compositions. Typically, xylitol is incorporated into a feedstock which is flash-flow processed to form a self-binding shearform matrix.

Abstract: In a transdermal cell, a matter volume-adjustment male device includes the lower opening end of the through-space structure having inner wall female threads mateable with first male threads of a screwable matter volume-adjustment male member alternately adjustable upwardly and downwardly between opposite upper and lower female threads-termination points. The screwable matter volume-adjustment member has opposite first upper and lower male threads-termination points, and the inner wall female threads are further concurrently mateable with a bottom closure member having second male threads having opposite second upper and lower male threads-termination points.