Patent number: 6291459
Abstract: A compound selected from Formula (I) hereinbelow:
or a pharmaceutically acceptable salt thereof, wherein
m is an integer from 0 to 2; n is an integer from 1 to 3;
X is selected from the group consisting of CN, NO2, Cl, F, and H;
Y is selected from the group consisting of Cl, F, Br, I and H; and
Q and Z are, independently, selected from the group consisting of H, R1, SO2R1′, R1C(O)OR1″, SO2NR1′R1″, C(O)NR1′R1″, NR1′SO2R″1, wherein R1, R1′ and R1″ are independently selected from the group consisting of hydrogen, C1-4 alkyl, C3-6 cycloalkyl, C2-5 alkenyl, C2-5 alkynyl, heterocycloalkyl, aryl and aryl C1-4 alkyl; or R1′ and R1″ together form a 3 to 7 membered optionally substituted heterocyclic ring; wherein any substituents are selected from the group consisting of CN, aryl, CO2R, CO2NHR, OH, OR, NH2, halo, CF3, OCF3 and NO2; wherein R represents H, C1-4 alkyl, and C3-6 cycloalkyl; and A is phenyl or naphthyl, unsubstit
Type:
Grant
Filed:
April 9, 2001
Date of Patent:
September 18, 2001
Assignee:
SmithKline Beecham Corporation
Inventors:
Pradip Bhatnagar, Maria Amparo Lago
