Patents by Inventor Pradip K. Chakraborti

Pradip K. Chakraborti has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Super glucocorticoid receptors: receptors with increased affinity and specificity for glucocorticoid steriods
    Patent number: 5215916
    Abstract: The present invention relates to novel glucocorticoid receptors that have greater affinity and specifity for glucocorticoid steroids than the naturally occurring receptors. More particularly, the invention relates to the altering of the equivalent of cysteine-656 of the rat glucocorticoid receptor to either serine or glycine for the production of super glucocorticoid receptors which retain full biological activity in intact cells and have higher affinity and specificity for glucocorticoid steroid binding than the original receptor. The invention further relates to the recombinant expression of such altered receptors in host cells.
    Type: Grant
    Filed: June 19, 1991
    Date of Patent: June 1, 1993
    Assignee: The United States of America as represented by the Department of Health & Human Services
    Inventors: Samuel S. Simons, Jr., Pradip K. Chakraborti, Keith R. Yamamoto, Michael J. Garabedian