Patents by Inventor Pradyot Dash

Pradyot Dash has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • CLONING AND EXPRESSION SYSTEM FOR T-CELL RECEPTORS
    Publication number: 20260062696
    Abstract: The invention provides a method for rapid cloning of T-cell receptors (TCRs) (e.g., paired ?? and ?? TCR chains) and B-cell receptors (BCRs) (e.g., paired IgH or IgK or Ig?) from single cells by CDR3 substitution using single cell PCR products and Gibson Assembly techniques and a pre-generated TCR (or BCR) library in an expression vector.
    Type: Application
    Filed: April 7, 2025
    Publication date: March 5, 2026
    Applicant: St. Jude Children's Research Hospital, Inc.
    Inventors: Paul Thomas, Xizhi Guo, Pradyot Dash
  • CHIMERIC ANTIGEN RECEPTOR THERAPIES FOR TREATING CANCER WITH IL7Fc ARMORED CAR-T CELLS
    Publication number: 20260000765
    Abstract: Novel anti-effector moiety antibodies or antigen binding domains thereof and CARs that contain such effector moiety antigen binding domains, either with or without one or more booster elements, and host cells expressing the receptors, and nucleic acid molecules encoding the receptors are provided herein, as well as methods of use of same in a patient-specific immunotherapy that can be used to treat solid tumor cancers and other diseases and conditions.
    Type: Application
    Filed: June 27, 2025
    Publication date: January 1, 2026
    Inventors: Soumyadeep Dey, Zhongyu Zhu, Yanping Xie, Bang Khoa Vu, Pradyot Dash
  • Cloning and expression system for T-cell receptors
    Patent number: 12297427
    Abstract: The invention provides a method for rapid cloning of T-cell receptors (TCRs) (e.g., paired ?? and ?? TCR chains) and B-cell receptors (BCRs) (e.g. paired IgH or IgK or Ig?) from single cells by CDR3 substitution using single cell PCR products and Gibson Assembly techniques and a pre-generated TCR (or BCR) library in an expression vector.
    Type: Grant
    Filed: December 2, 2016
    Date of Patent: May 13, 2025
    Assignee: ST. JUDE CHILDREN'S RESEARCH HOSPITAL, INC.
    Inventors: Paul Thomas, Xizhi Guo, Pradyot Dash
  • KIT AND METHOD FOR ANALYZING SINGLE T CELLS
    Publication number: 20220259670
    Abstract: A kit and method for analyzing nucleic acid molecules encoding T cell receptor (TCR) a and ? from individual T cells are disclosed. In particular, a method for analyzing individual T cells using high-throughput multiplex amplification and deep sequencing of nucleic acids encoding TCR?? is provided.
    Type: Application
    Filed: June 30, 2020
    Publication date: August 18, 2022
    Inventors: Pradyot DASH, Paul THOMAS
  • CLONING AND EXPRESSION SYSTEM FOR T-CELL RECEPTORS
    Publication number: 20190040381
    Abstract: The invention provides a method for rapid cloning of T-cell receptors (TCRs) (e.g., paired ?? and ?? TCR chains) and B-cell receptors (BCRs) (e.g. paired IgH or IgK or Ig?) from single cells by CDR3 substitution using single cell PCR products and Gibson Assembly techniques and a pre-generated TCR (or BCR) library in an expression vector.
    Type: Application
    Filed: December 2, 2016
    Publication date: February 7, 2019
    Applicant: St. Jude Children's Research Hospital, Inc.
    Inventors: Paul Thomas, Xizhi Guo, Pradyot Dash