Patents by Inventor Praful Shamrao Chavre

Praful Shamrao Chavre has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • AN IMPROVED PROCESS FOR FMOC SYNTHESIS OF ETELCALCETIDE
    Publication number: 20230331778
    Abstract: The present invention relates to an improved process for the synthesis of Etelcalcetide and its analogs by solid phase synthesis of Fmoc protected amino acids in a sequential manner, followed by acetylation of terminal D-cys and cleavage of peptide from solid support. The crude heptapeptide thus obtained is reduced using Tris(2-carboxyethyl) phosphine hydrochloride, purified and oxidized with L-cysteine. The oxidized Etelcalcetide is purified and salt exchanged using a one-step reverse phase chromatography process. The purified Etelcalcetide hydrochloride is then precipitated using organic solvents, concentrated and lyophilized to purity of greater than 99.0%.
    Type: Application
    Filed: August 31, 2021
    Publication date: October 19, 2023
    Inventors: Lester John Lobo, Muralidharan Chandrakesan, Chetan Doshi, Shailesh Lalchand Chanadak, Nandlal Gopal Yadav, Nikhil Umesh Mohe, Kodandaraman Vishwanathan, Praful Shamrao Chavre
  • Process for the synthesis of 37-mer peptide pramlintide
    Patent number: 8846614
    Abstract: A process for the production of pramlintide, a 37-mer peptide, is provided. The synthesis provides a high yield synthesis of the peptide in relatively pure form. Further purification can be achieved by preparative HPLC.
    Type: Grant
    Filed: August 22, 2012
    Date of Patent: September 30, 2014
    Assignee: USV Limited
    Inventors: Nikhil Umesh Mohe, Praful Shamrao Chavre, Bharti Prabhakarrao Deshmukh, Chandrakesan Muralidharan, Lester John Lobo, Digamber Shripati Pawar, Divya Lal Saksena
  • NOVEL PROCESS FOR THE SYNTHESIS OF 37-MER PEPTIDE PRAMLINTIDE
    Publication number: 20130109622
    Abstract: A process for the production of pramlintide, a 37-mer peptide, is provided. The synthesis provides a high yield synthesis of the peptide in relatively pure form. Further purification can be achieved by preparative HPLC.
    Type: Application
    Filed: August 22, 2012
    Publication date: May 2, 2013
    Applicant: USV Limited
    Inventors: Nikhil Umesh Mohe, Praful Shamrao Chavre, Bhartri Prabhakarrao Deshmukh, Chandrakesan Muralidharan, Lester John Lobo, Digamber Shripati Pawar, Divya Lal Saksena