Patents by Inventor Prafulla Gokhale
Prafulla Gokhale has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20110104252Abstract: A gene that is a positive mediator of tumor growth and metastasis in certain cancer types is provided. This gene and corresponding polypeptide have diagnostic and therapeutic application for detecting and treating cancers that involve expression of SCC-S2 such as renal, ovarian, head and neck, breast, prostate, brain, chronic myelogenous leukemia, lung, lymphoblastic leukemia, and colorectal adenocarcinoma cells.Type: ApplicationFiled: August 17, 2010Publication date: May 5, 2011Applicant: GEORGETOWN UNIVERSITYInventors: USHA KASID, Deepak Kumar, Prafulla Gokhale, Imran Ahmad
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Publication number: 20100041142Abstract: A gene that is a positive mediator of tumor growth and metastasis in certain cancer types is provided. This gene and corresponding polypeptide have diagnostic and therapeutic application for detecting and treating cancers that involve expression of SCC-S2 such as renal, ovarian, head and neck, breast, prostate, brain, chronic myelogenous leukemia, lung, lymphoblastic leukemia, and colorectal adenocarcinoma cells.Type: ApplicationFiled: May 18, 2009Publication date: February 18, 2010Applicant: Georgetown UniversityInventors: Usha Kasid, Deepak Kumar, Prafulla Gokhale, Imran Ahmad
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Patent number: 7442520Abstract: A gene that is a modulator of tumor growth and metastasis in certain cancer types is provided. This gene and corresponding polypeptide have diagnostic and therapeutic application for detecting and treating cancers that involve expression of BRCC-3 such as breast cancer and lung cancer.Type: GrantFiled: October 6, 2003Date of Patent: October 28, 2008Assignee: Georgetown UniversityInventors: Usha Kasid, Prafulla Gokhale, Deepak Kumar, Howard Boudreau, Imran Ahmad, Anatoly Dritschilo, Aquilur Rahman
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Patent number: 7262173Abstract: The invention relates to the use of oligonucleotide containing cationic liposomal formulations to enhance the efficacy of chemotherapy and/or radiotherapy, particularly as a means to sensitize cancerous tumor tissues to the efficiencies of chemotherapy. This is particularly advantageous in the context of treating raf expressing tumors such as breast, lung, pancreatic and prostate tumors.Type: GrantFiled: February 15, 2002Date of Patent: August 28, 2007Assignees: Georgetown University, NeoPharm, Inc.Inventors: Usha Kasid, Prafulla Gokhale, Jin Pei, Rajshree Mewani, Imran Ahmad, Anatoly Dritschilo, Aquilur Rahman
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Patent number: 7253272Abstract: A gene that is a modulator of tumor growth and metastasis in certain cancer types is provided. This gene and corresponding polypeptide have diagnostic and therapeutic application for detecting and treating cancers that involve expression of BRCC2 such as breast cancer and lung cancer.Type: GrantFiled: October 6, 2003Date of Patent: August 7, 2007Assignee: Georgetown UniversityInventors: Usha Kasid, Prafulla Gokhale, Deepak Kumar, Constantinos Broustas, Imran Ahmad, Anatoly Dritschilo, Aquilur Rahman
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Publication number: 20070104718Abstract: A gene that is a modulator of tumor growth and metastasis in certain cancer types is provided. This gene and corresponding polypeptide have diagnostic and therapeutic application for detecting and treating cancers that involve expression of BRCC-1 such as breast cancer and lung cancer.Type: ApplicationFiled: September 28, 2006Publication date: May 10, 2007Inventors: Prafulla Gokhale, Anatoly Dritschilo, Aquilur Rahman, Imran Ahmad, Usha Kasid
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Publication number: 20070087992Abstract: A gene that is a positive mediator of tumor growth and metastasis in certain cancer types is provided. This gene and corresponding polypeptide have diagnostic and therapeutic application for detecting and treating cancers that involve expression of SCC-S2 such as renal, ovarian, head and neck, breast, prostate, brain, chronic myelogenous leukemia, lung, lymphoblastic leukemia, and colorectal adenocarcinoma cells.Type: ApplicationFiled: November 16, 2006Publication date: April 19, 2007Applicant: Georgetown University, Office of Technology LicensingInventors: Usha Kasid, Deepak Kumar, Prafulla Gokhale, Imran Ahmad
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Publication number: 20060141020Abstract: It is possible to radiosensitize tumor cells by administration of compositions containing the Human antisense c-raf-1 oligodeoxyribonucleotide (ODN/oligo) sequence: 5?-GTGCTCCATTGATGC-3? (SEQ. ID. NO: 1) wherein only the end bases are phosphorothioated is a preferred embodiment. Antisense sequences of up to 40 bases which contain this sequence, such as 5?-CCTGTATGTGCTCCATTGATGCAGC-3? (SEQ ID NO: 2) may be used in accord with the teachings of this disclosure. Compositions comprising a cationic liposome of dimethyldioctadecyl ammonium bromide, phosphatidylcholine and cholesterol may be used as a carrier system. The liposomes provide a new carrier system that is particularly useful for administration of sequences for therapy.Type: ApplicationFiled: December 10, 2004Publication date: June 29, 2006Applicant: Georgetown UniversityInventors: Usha Kasid, Prafulla Gokhale, Chuanbo Zhang, Anatoly Dritschilo, Aquilur Rahman
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Publication number: 20040115714Abstract: A gene that is a modulator of tumor growth and metastasis in certain cancer types is provided. This gene and corresponding polypeptide have diagnostic and therapeutic application for detecting and treating cancers that involve expression of BRCC2 such as breast cancer and lung cancer.Type: ApplicationFiled: October 6, 2003Publication date: June 17, 2004Applicants: Georgetown University, NeoPharm, Inc.Inventors: Usha Kasid, Prafulla Gokhale, Deepak Kumar, Constantinos Broustas, Imran Ahmad, Anatoly Dritschilo, Aquilur Rahman
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Publication number: 20040106571Abstract: A gene that is a modulator of tumor growth and metastasis in certain cancer types is provided. This gene and corresponding polypeptide have diagnostic and therapeutic application for detecting and treating cancers that involve expression of BRCC-3 such as breast cancer and lung cancer.Type: ApplicationFiled: October 6, 2003Publication date: June 3, 2004Applicants: Georgetown University, NeoPharm, Inc.Inventors: Usha Kasid, Prafulla Gokhale, Deepak Kumar, Howard Boudreau, Imran Ahmad, Anatoly Dritschilo, Aquilur Rahman
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Publication number: 20040082771Abstract: A gene that is a positive mediator of tumor growth and metastasis in certain cancer types is provided. This gene and corresponding polypeptide have diagnostic and therapeutic application for detecting and treating cancers that involve expression of SCC-S2 such as renal, ovarian, head and neck, breast, prostate, brain, chronic myelogenous leukemia, lung, lymphoblastic leukemia, and colorectal adenocarcinoma cells.Type: ApplicationFiled: July 25, 2003Publication date: April 29, 2004Applicants: Georgetown University, NeoPharm, Inc.Inventors: Usha Kasid, Deepak Kumar, Prafulla Gokhale, Imran Ahmad
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Publication number: 20030228317Abstract: A gene that is a modulator of tumor growth and metastasis in certain cancer types is provided. This gene and corresponding polypeptide have diagnostic and therapeutic application for detecting and treating cancers that involve expression of BRCC-1 such as breast cancer and lung cancer.Type: ApplicationFiled: May 22, 2003Publication date: December 11, 2003Inventors: Prafulla Gokhale, Anatoly Dritschilo, Aquilur Rahman, Imran Ahmad, Usha Kasid
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Publication number: 20030229040Abstract: The invention relates to novel cationic lipid formulations and use thereof for treatment of cancer, especially in combination with radiation.Type: ApplicationFiled: January 21, 2003Publication date: December 11, 2003Applicant: GEORGETOWN UNIVERSITYInventors: Usha Kasid, Prafulla Gokhale, Chuanbo Zhang, Anatoly Dritschilo, Aquilur Rahman
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Publication number: 20030215489Abstract: The invention relates to the use of oliognucleotide containing cationic liposomal formulations to enhance the efficacy of chemotherapy and/or radiotherapy, particularly as a means to chemosensitize cancer are tumor tissues to the efficiencies of chemotherapy. This is particularly advantageous in the context of treatment of ras expressing tumors such as breast, lung, pancreatic and prostate cancer.Type: ApplicationFiled: February 15, 2002Publication date: November 20, 2003Applicant: Georgetown UniversityInventors: Usha Kasid, Prafulla Gokhale, Jin Pei, Rajshree Mewani, Imran Ahmad, Anatoly Dritschilo, Aquilur Rahman
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Patent number: 6559129Abstract: The invention relates to novel cationic lipid formulations and use thereof for treatment of cancer, especially in combination with radiation.Type: GrantFiled: March 30, 2000Date of Patent: May 6, 2003Assignee: Georgetown UniversityInventors: Usha Kasid, Prafulla Gokhale, Chuanbo Zhang, Anatoly Dritschilo, Aquilar Rahman
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Publication number: 20020160038Abstract: It is possible to radiosensitize tumor cells by administration of compositions containing the Human antisense c-raf-1 oligodeoxyribonucleotide (ODN/oligo) sequence: 5′-GTGCTCCATTGATGC-3′ (seq. #1) wherein only the end bases are phosphorylated is a preferred embodiment. Antisense sequences of up to 40 bases which containing this sequence may be used in accord with the teachings of this disclosure. Compositions comprising a cationic liposome of dimethyldioctadecyl ammonium bromide, phosphatidylcholine and cholesterol may be used as a carrier system. The liposomes provide a new carrier system that is particularly useful for administration of sequences for therapy.Type: ApplicationFiled: August 16, 2001Publication date: October 31, 2002Applicant: Georgetown University School of MedicineInventors: Usha Kasid, Prafulla Gokhale, Chuanbo Zhang, Anatoly Dritschilo, Aquilur Rahman
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Patent number: 6333314Abstract: It is possible to radiosensitize tumor cells by administration of compositions containing the Human antisense c-raf-1 oligodeoxyribonucleotide (ODN/oligo) sequence: 5′-GTGCTCCATTGATGC-3′ (seq. ID No. 1) wherein only the end bases are phosphorylated is a preferred embodiment. Antisense sequences of up to 40 bases which containing this sequence may be used in accord with the teachings of this disclosure. Compositions comprising a cationic liposome of dimethyldioctadecyl ammonium bromide, phosphatidylcholine and cholesterol may be used as a carrier system. The liposomes provide a new carrier system that is particularly useful for administration of sequences for therapy.Type: GrantFiled: January 13, 2000Date of Patent: December 25, 2001Assignee: Georgetown University School of MedicineInventors: Usha Kasid, Prafulla Gokhale, Anatoly Dritschilo, Aquilur Rahman
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Patent number: 6126965Abstract: It is possible to radiosensitize tumor cells by administration of compositions containing the Human antisense c-raf-1 oligodeoxyribonucleotide (ODN/oligo) sequence: 5'-GTGCTCCATTGATGC-3' (seq. #1) wherein only the end bases are phosphorylated is a preferred embodiment. Antisense sequences of up to 40 bases which containing this sequence may be used in accord with the teachings of this disclosure. Compositions comprising a cationic liposome of dimethyldioctadecyl ammonium bromide, phosphatidylcholine and cholesterol may be used as a carrier system. The liposomes provide a new carrier system that is particularly useful for administration of sequences for therapy.Type: GrantFiled: October 24, 1997Date of Patent: October 3, 2000Assignee: Georgetown University School of MedicineInventors: Usha Kasid, Prafulla Gokhale, Anatoly Dritschilo, Aquilur Rahman