Patents by Inventor Prakash Bansode

Prakash Bansode has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for the introduction of hydroxyethoxy side chain in bosentan
    Patent number: 8664390
    Abstract: The present invention relates to an improved process for the preparation of bosentan. In particular it relates to a process for preparing bosentan substantially free from the dimer impurity of formula (II) and the 6-hydroxy impurity of formula (III). The invention also relates to a pharmaceutical composition comprising bosentan and its use in the treatment of endothelin-receptor mediated disorders.
    Type: Grant
    Filed: June 27, 2008
    Date of Patent: March 4, 2014
    Assignee: Generics (UK) Limited
    Inventors: Abhay Gaitonde, Bindu Manojkumar, Sandeep Sonawane, Dattatrey Kokane, Sandeep Mekde, Dattatraya Shinde, Prakash Bansode
  • Process for the production of etravirine
    Patent number: 8653266
    Abstract: A novel process for the preparation of Etravirine comprises the condensing of ethyl cyanoacetate with N-cyanophenylguanidine to obtain an —OH compound of formula (II), which is further converted to a leaving group of formula (III). The compound of formula (III) is optionally protected and brominated to yield compound of formula (IV). The condensation of formula (IV) with 3,5-dimethyl-4-hydroxybenzonitrile yields a compound of formula (VI), and an optional deprotection of the compound of formula (VI) results in Etravirine.
    Type: Grant
    Filed: April 26, 2012
    Date of Patent: February 18, 2014
    Assignee: Mylan Laboratories Limited
    Inventors: Vinayak Gore, Choudhari Bharati, Mahesh Hublikar, Prakash Bansode, Sandip Sinore
  • Crystalline forms of bosentan
    Patent number: 8530488
    Abstract: The present invention relates to novel crystalline forms of bosentan and processes for their preparation. Further, the invention relates to pharmaceutical compositions comprising said crystalline forms and use of said compositions in the treatment of patients suffering from endothelin receptor mediated disorders, for example, cardiovascular disorders such as hypertension, pulmonary hypertension, ischemia, vasospasm and angina pectoris.
    Type: Grant
    Filed: October 24, 2008
    Date of Patent: September 10, 2013
    Assignee: Generics [UK] Limited
    Inventors: Abhay Gaitonde, Bindu Manojkumar, Sandeep Mekde, Prakash Bansode, Dattatraya Shinde, Sunanda Phadtare
  • PROCESS FOR THE PRODUCTION OF ETRAVIRINE
    Publication number: 20130116433
    Abstract: A novel process for the preparation of Etravirine comprises the condensing of ethyl cyanoacetate with N-cyanophenylguanidine to obtain an —OH compound of formula (II), which is further converted to a leaving group of formula (III). The compound of formula (III) is optionally protected and brominated to yield compound of formula (IV). The condensation of formula (IV) with 3,5-dimethyl-4-hydroxybenzonitrile yields a compound of formula (VI), and an optional deprotection of the compound of formula (VI) results in Etravirine.
    Type: Application
    Filed: April 26, 2012
    Publication date: May 9, 2013
    Inventors: Vinayak Gore, Choudhari Bharati, Mahesh Hublikar, Prakash Bansode, Sandip Sinore
  • Polymorphic forms
    Patent number: 8288401
    Abstract: Novel polymorphic forms of bosentan and processes for their preparation are disclosed. Further, pharmaceutical compositions comprising said polymorphic forms and the use of said compositions in the treatment of patients suffering from endothelin receptor mediated disorders, for example, cardiovascular disorders such as hypertension, pulmonary hypertension, ischemia, vasospasm and angina pectoris are disclosed.
    Type: Grant
    Filed: May 8, 2008
    Date of Patent: October 16, 2012
    Assignee: Generics [UK] Limited
    Inventors: Abhay Gaitonde, Bindu Manojkumar, Sandeep Mekde, Dattaatraya Shinde, Prakash Bansode
  • CRYSTALLINE FORM OF SUNITINIB AND PROCESSES FOR ITS PREPARATION
    Publication number: 20120029046
    Abstract: The present invention relates to a novel crystalline form of sunitinib free base designated form I and to processes for its preparation. The invention also relates to its use as an API and in the preparation of various forms of sunitinib. Further, the invention relates to pharmaceutical compositions comprising the novel crystalline form and salts, solvates and hydrates prepared according to the invention, and to the uses of said pharmaceutical compositions in the treatment and/or prevention of cancer.
    Type: Application
    Filed: August 24, 2009
    Publication date: February 2, 2012
    Applicant: Generics (UK) Limited
    Inventors: Vinayak Gore, Bharati Choudhari, Mahesh Hublikar, Prakash Bansode
  • Preparation of 3-Pyrrole Substituted 2-Indolinone Derivatives
    Publication number: 20110275689
    Abstract: The present invention relates to novel intermediates and further to the use of said intermediates in processes for the preparation of indolinone derivatives, in particular 3-pyrrole substituted 2-indolinones having amide moieties on the pyrrole ring. Such compounds are useful in die treatment of abnormal cell growth, such as cancer, in mammals.
    Type: Application
    Filed: July 1, 2009
    Publication date: November 10, 2011
    Applicant: GENERICS [UK] LIMITED
    Inventors: Abhay Gaitonde, Bharati Choudhari, Prakash Bansode, Sunanda Phadtare
  • NOVEL POLYMORPHS OF SUNITINIB AND PROCESSES FOR THEIR PREPARATION
    Publication number: 20110263670
    Abstract: The present invention relates to novel polymorphs of sunitinib free base designated form II and form III and to processes for their preparation. The invention also relates to their use as APIs and in the preparation of various forms of sunitinib. Further, the invention relates to pharmaceutical compositions comprising said novel polymorphs and salts, solvates and hydrates prepared according to the invention, and to the uses of said pharmaceutical compositions in the treatment and/or prevention of cancer.
    Type: Application
    Filed: August 24, 2009
    Publication date: October 27, 2011
    Inventors: Vinayak Gore, Bharati Choudhari, Mahesh Hublikar, Prakash Bansode
  • PROCESS FOR THE PREPARATION OF CRYSTALLINE FORMS OF SUNITINIB MALATE
    Publication number: 20110257237
    Abstract: The present invention, relates to novel processes for the preparation of sunitinib malate formula (I), pharmaceutical compositions comprising said polymorph and the use of the said pharmaceutical compositions in the treatment of various forms of cancer.
    Type: Application
    Filed: July 9, 2009
    Publication date: October 20, 2011
    Applicant: GENERICS [UK] LIMITED
    Inventors: Abhay Gaitonde, Vinayak Gore, Bharati Choudhari, Mahesh Hublikar, Prakash Bansode, Sunanda Phadtare
  • NOVEL POLYMORPHS AND PROCESSES FOR THEIR PREPARATION
    Publication number: 20110112164
    Abstract: The present invention relates to novel polymorph forms III and IV of sunitinib malate, pharmaceutical compositions comprising the novel polymorphs and the use of the pharmaceutical compositions. The present invention further relates to processes for the preparation of polymorph form I, III and IV of sunitinib malate.
    Type: Application
    Filed: February 20, 2009
    Publication date: May 12, 2011
    Applicants: Generics (UK) Limited, Mylan India Private Limited
    Inventors: Abhay Gaitonde, Bharati Choudhari, Prakash Bansode, Sunanda Phadtare
  • NOVEL POLYMORPHIC FORMS
    Publication number: 20100261742
    Abstract: Novel polymorphic forms of bosentan and processes for their preparation are disclosed. Further, pharmaceutical compositions comprising said polymorphic forms and the use of said compositions in the treatment of patients suffering from endothelin receptor mediated disorders, for example, cardiovascular disorders such as hypertension, pulmonary hypertension, ischemia, vasospasm and angina pectoris are disclosed.
    Type: Application
    Filed: May 8, 2008
    Publication date: October 14, 2010
    Inventors: Abhay Gaitonde, Bindu Manojkumar, Sandeep Mekde, Dattatraya Shinde, Prakash Bansode
  • PROCESS FOR THE INTRODUCTION OF HYDROXYETHOXY SIDE CHAIN IN BOSENTAN
    Publication number: 20100249162
    Abstract: The present invention relates to an improved process for the preparation of bosentan. In particular it relates to a process for preparing bosentan substantially free from the dimer impurity of formula (II) and the 6-hydroxy impurity of formula (III). The invention also relates to a pharmaceutical composition comprising bosentan and its use in the treatment of endothelin-receptor mediated disorders.
    Type: Application
    Filed: June 27, 2008
    Publication date: September 30, 2010
    Inventors: Abhay Gaitonde, Bindu Manojkumar, Sandeep Sonawane, Dattatrey Kokane, Sandeep Mekde, Dattatraya Shinde, Prakash Bansode