Abstract: This invention provides a range of translatable polynucleotide and oligomer molecules for expressing a human amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase (AGL), or a fragment thereof having AGL activity. The polynucleotide and oligomer molecules are expressible to provide the human AGL or a fragment thereof having AGL activity. The molecules can be used as active agents to express an active polypeptide or protein in cells or subjects. The agents can be used in methods for ameliorating, preventing, delaying onset, or treating a disease or condition associated with reduced activity of amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase (AGL) in a subject.

Abstract: Disclosed herein is a computer implemented method and system for ranking a user in an organization based on the user's information technology related activities and arriving at an end risk score used for determining the risk involved in activities performed by the user and for other purposes. Group risk ranking profiles and security policies for usage of the organization's resources are created. The user is associated with one or more group risk ranking profiles. A security client application tracks the user's activities. Points are assigned to the user's tracked activities based on each of the associated group risk ranking profiles. The assigned points are aggregated to generate a first risk score. The assigned points of the user's tracked activities are modified at different levels based on predefined rules. The modified points are aggregated to generate the end risk score which is used for compliance and governance purposes, optimizing resources, etc.