Abstract: The present invention discloses modified forms of plasmin with advantageous properties. As compared to their natural unmodified form, these variants exhibit significantly modulated kinetics in terms of delayed inhibition characteristics in the presence of specific inhibitors, such as ?2-antiplasmin (?2-AP). These include PEG-conjugated thiol derivatives of truncated plasmin with potential clinical applications in various regimens of thrombolytic therapies.

Abstract: A threat management facility receives data from a variety of sources such as compute instances within an enterprise network, cloud service providers supporting the enterprise network, and third-party data providers such as geolocation services. In order to facilitate prompt notification of potential risks, the threat management facility may incrementally update data for use in threat assessments as the data becomes available from these different sources, and create suitable alerts or notifications whenever the currently accumulated data provides an indication of threat meeting a predetermined threshold.

Abstract: A medical device communication method that may be implemented within a variety of medical devices including but not limited to infusion pumps. The method may be implemented with a protocol stack for at least intra-device communication. Embodiments provide connection-oriented, connectionless-oriented, broadcast and multicast data exchange with priority handling of data, fragmentation, and reassembly of data, unique static and dynamic address assignment and hot swap capability for connected peripherals or subsystems.

Abstract: The present disclosure describes a circuit that may include a first amplifier portion configured to receive a first input signal corresponding to a first clock signal and a second input signal corresponding to a second clock signal. The circuit may include a first amplifier of the first amplifier portion. The first amplifier may be configured to receive a first amplifier input signal and a second amplifier input signal. The circuit may include a second amplifier portion configured to receive a first output signal from the first amplifier portion. In a first mode, the first amplifier input signal may be based upon the second input signal and the second amplifier input signal may be based upon the first input signal. In a second mode, the first amplifier input signal may be based upon the first input signal and the second amplifier input signal may be based upon the second input signal.

Abstract: An asynchronous stream of security events is added to a data lake for enterprise security by identifying groups of related events related to a security threat, and creating rules to fold these related events into a single security event along with metadata. The folding rules may then be applied to security events in the event stream to compress data in the data lake and improve detection efficiency.

Abstract: A platform for threat investigation in an enterprise network receives threat data from managed endpoints, and is augmented with data from cloud computing platforms and other third-party resources. The resulting merged data set can be incrementally updated and used to automatically launch investigations at appropriate times.

Abstract: A threat management facility receives data from a variety of sources such as compute instances within an enterprise network, cloud service providers supporting the enterprise network, and third-party data providers such as geolocation services. In order to facilitate prompt notification of potential risks, the threat management facility may incrementally update data for use in threat assessments as the data becomes available from these different sources, and create suitable alerts or notifications whenever the currently accumulated data provides an indication of threat meeting a predetermined threshold.

Abstract: Techniques and solutions are provided for increasing the energy efficiency of computing code. Many computing operations can be implemented in a number of different ways. While the end result of each implementation may be the same, the energy efficiency of the implementations can vary dramatically. Disclosed techniques provide rules that can be used to analyze code for a particular implementation of an operation. If a rule is triggered, a recommendation to replace the implementation with a more energy efficiency implementation can be provided, or the code can automatically be changed to include the more energy efficient implementation. Techniques for defining rules are also provided, such as by measuring or estimating energy used by various ways of implementing an operation. Measurement or estimation of energy used during code execution can be performed in a containerized environment, such as to provide improved accuracy, and allow for parallelization.

Abstract: A threat management system stores an attack matrix characterizing tactics and techniques, and provides threat detection based on patterns of traversal of the attack matrix. Where the threat management system provides a data lake of security events and a query interface for using the data lake to investigate security issues, useful inferences may also be drawn by comparing query activity in the query interface with the patterns of traversal of the attack matrix, such as by using a malicious pattern of traversal to identify a concurrent chain of queries indicative of a threat, or by presenting separate threat scores to an analyst based on query activity and patterns of traversal.

Abstract: An asynchronous stream of security events is added to a data lake for enterprise security by identifying groups of related events related to a security threat, and creating rules to fold these related events into a single security event along with metadata. The folding rules may then be applied to security events in the event stream to compress data in the data lake and improve detection efficiency.

Abstract: A threat management facility receives data from a variety of sources such as compute instances within an enterprise network, cloud service providers supporting the enterprise network, and third-party data providers such as geolocation services. In order to facilitate prompt notification of potential risks, the threat management facility may incrementally update data for use in threat assessments as the data becomes available from these different sources, and create suitable alerts or notifications whenever the currently accumulated data provides an indication of threat meeting a predetermined threshold.

Abstract: A medical device communication method that may be implemented within a variety of medical devices including but not limited to infusion pumps. The method may be implemented with a protocol stack for at least intra-device communication. Embodiments provide connection-oriented, connectionless-oriented, broadcast and multicast data exchange with priority handling of data, fragmentation, and reassembly of data, unique static and dynamic address assignment and hot swap capability for connected peripherals or subsystems.

Abstract: Embodiments included herein are directed towards a voltage-temperature drift resistant and power efficient clock distribution circuit. Embodiments may include a current generator and a voltage generator configured to receive an input from the current generator. Embodiments may also include a regulator which may be configured to receive a reference voltage from the voltage generator as an input and to generate regulated voltage as output. The clock distribution path may operate on a regulated voltage, the regulated voltage having a value proportional to a threshold value associated with a plurality of devices included in the clock distribution path.

Abstract: A method for use in planning of tasks to be performed by one or more vehicles within an evolving site includes obtaining a request relating to at least one task to be performed by the one or more vehicles, wherein the at least one task involves at least travelling from a starting location to a target location, obtaining geographic location data comprising at least the starting location and the target location, obtaining site data from at least a dynamic BIM of the site, planning of the at least one task by using at least the request, the geographic location data, and the site data as input data to a prediction model, wherein the planning of the at least one task comprises at least planning of a travel path within the site, providing information relating to the planned at least one task to be presented via at least one user interface, and generating site update data for updating the dynamic BIM based on user input.

Abstract: Described herein is an anti-dandruff composition including at least two anti-dandruff actives selected from a punicalagin composition; a first monoterpenoid composition, or a second monoterpenoid composition; and a dermatologically-acceptable carrier. The two or more anti-dandruff actives are present in the anti-dandruff composition in an effective amount to treat or prevent dandruff caused by the proliferation of Malassezia furfur.

Abstract: In accordance with an embodiment, described herein are systems and methods for (a) determining workflow characteristics for use with an integration cloud service or other computing environment; and (b) providing a marketplace that employs a conversational interface to guide users in selecting and retrieving integration artifacts, for example workflows or other assets, to address particular needs. A collection service can receive an indication of an integration archive that defines a business workflow or integration flow, wherein a characteristics server can then extract and persist the characteristics associated with the workflow, for subsequent use in providing a determination of workflows. In accordance with an embodiment, a digital assistant can be employed to allow discovery of workflows by building a discovery criteria based on a knowledge of characteristics associated with various business workflows or integration flows, and through interactive conversations by a user with the digital assistant.

Abstract: In accordance with an embodiment, described herein is a system and method for behavior injection in a cloud computing platform (cloud platform) or software application, including the use of injection points to modify the operation or behavior of a tenant platform environment. An injection service enables a cloud platform provider to configure software code/behaviors to be injected into cloud platform modules or other components associated with tenants, including mapping, for a tenant-specific globally unique identifier (GUID) associated with a lifecycle activity injection point, a behavior including a platform code or process and metadata that can be used to inject and modify operation of a corresponding module. The described approach enables a cloud platform to expose behavioral aspects of the cloud platform or a software application executing therein, so that they can be controlled or modified in a dynamic manner, from outside of the cloud platform.

Abstract: Aspects of the present disclosure relate to identifying relationships between entities in a user graph relative to a specific user. The identified relationships may provide user specific insights on related entities from across the enterprise environment. The insights may be provided to the user in a graphical user interface which may organize the insights into categories of information with selectable features to permit user interaction with the insights. Thus, the insights provided from the user graph or user sub-graph according to aspects described herein, may improve productivity and the potential for collaboration across the enterprise environment while reducing user workload.

Abstract: Described herein is an anti-dandruff composition including at least two anti-dandruff actives selected from a punicalagin composition; a first monoterpenoid composition, or a second monoterpenoid composition; and a dermatologically-acceptable carrier. The two or more anti-dandruff actives are present in the anti-dandruff composition in an effective amount to treat or prevent dandruff caused by the proliferation of Malassezia furfur.

Abstract: In accordance with an embodiment, described herein are systems and methods for (a) determining workflow characteristics for use with an integration cloud service or other computing environment; and (b) providing a marketplace that employs a conversational interface to guide users in selecting and retrieving integration artifacts, for example workflows or other assets, to address particular needs. A collection service can receive an indication of an integration archive that defines a business workflow or integration flow, wherein a characteristics server can then extract and persist the characteristics associated with the workflow, for subsequent use in providing a determination of workflows. In accordance with an embodiment, a digital assistant can be employed to allow discovery of workflows by building a discovery criteria based on a knowledge of characteristics associated with various business workflows or integration flows, and through interactive conversations by a user with the digital assistant.