Patents by Inventor Prakash Yashwant Kolhe

Prakash Yashwant Kolhe has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • One pot process for preparing 2-butyl-3-[[2?-(1H-tetrazol-5-yl)[1,1?-biphenyl]-4-yl]methyl]-1,3-diazaspiro [4, 4] non-1-en-4-one (irbesartan)
    Patent number: 8609859
    Abstract: A one pot process for the synthesis of Irbesartan comprising reacting 2-n-Butyl-1,3-Diazaspiro[4,4]Non-1-en-4-one (Formula III) and Bromomethyl Cyanobiphenyl (Formula IV) in the presence of base and water with the optional use of PTC to give formula II from which Irbesartan is obtained by reacting with sodium azide and triethylamine hydrochloride in the presence of a non polar solvent.
    Type: Grant
    Filed: November 19, 2009
    Date of Patent: December 17, 2013
    Assignee: CTX Life Sciences Pvt. Ltd.
    Inventors: Prakash Yashwant Kolhe, Rajesh Dilip Joshi, Bimal Kumar Srivastava, Nitin Jerambhai Patel, Sanket Sureshbhai Gajjar
  • ONE POT PROCESS FOR PREPARING 2-BUTYL-3-[[2'-(1H-TETRAZOL-5-YL)[1,1'-BIPHENYL]-4-YL]METHYL]-1,3-DIAZASPIRO [4, 4] NON-1-EN-4-ONE (IRBESARTAN)
    Publication number: 20120116093
    Abstract: A one pot process for the synthesis of Irbesartan comprising reacting 2-n-Butyl-1,3-Diazaspiro[4,4]Non-1-en-4-one (Formula III) and Bromomethyl Cyanobiphenyl (Formula IV) in the presence of base and water with the optional use of PTC to give formula II from which Irbesartan is obtained by reacting with sodium azide and triethylamine hydrochloride in the presence of a non polar solvent.
    Type: Application
    Filed: November 19, 2009
    Publication date: May 10, 2012
    Applicant: CTX Life Sciences Pvt. Ltd
    Inventors: Prakash Yashwant Kolhe, Rajesh Dilip Joshi, Bimal Kumar Srivastava, Nitin Jerambhai Patel, Sanket Sureshbhai Gajjar