Patents by Inventor Prakasham Ayyampudur Palanisamy

Prakasham Ayyampudur Palanisamy has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Anticancer property studies of chiral palladium N-heterocyclic carbene complexes and process for preparation thereof
    Patent number: 10421769
    Abstract: The present invention relates to the anticancer property studies of a series of chiral palladium N-heterocyclic carbene complexes of the general formula of (NHC)2PdX2 [NHC=chiral N-heterocyclic carbene ligand 1-(1S,2S,5R/1R,2R,5S)-menthyl-4-(R)-1,2,4-triazol-5-ylidene, wherein R=Et, allyl and CH2Ph; X?Br or OCOCF3], as designated by, (1S,2S,5R)-(1-3)b and (1R,2R,5S)-(1-3)b, (1S,2S,5R)-(1, 3)c and (1R,2R,5S)-(1, 3)c represented by formula (Ig, Ih) below. The present invention further investigates the influence of chirality on the anticancer activity, wherein the enantiomeric pairs of present chiral palladium N-heterocyclic carbene complexes of formula (Ig, Ih) shows no differential activity based on optical isomerism despite all of the palladium complexes exhibiting high anti-proliferative activity towards a variety of cancer cells.
    Type: Grant
    Filed: November 8, 2017
    Date of Patent: September 24, 2019
    Assignee: India Institute of Technology Bombay
    Inventors: Anuj Kumar, Afsana Naaz, Prakasham Ayyampudur Palanisamy, Dulal Panda, Prasenjit Ghosh
  • ANTICANCER PROPERTY STUDIES OF CHIRAL PALLADIUM N-HETEROCYCLIC CARBENE COMPLEXES AND PROCESS FOR PREPARATION THEREOF
    Publication number: 20180194789
    Abstract: The present invention relates to the anticancer property studies of a series of chiral palladium N-heterocyclic carbene complexes of the general formula of (NHC)2PdX2 [NHC=chiral N-heterocyclic carbene ligand 1-(1S,2S,5R/1R,2R,5S)-menthyl-4-(R)-1,2,4-triazol-5-ylidene, wherein R=Et, allyl and CH2Ph; X=Br or OCOCF3], as designated by, (1S,2S,5R)-(1-3)b and (1R,2R,5S)-(1-3)b, (1S,2S,5R)-(1, 3)c and (1R,2R,5S)-(1, 3)c represented by formula (Ig, Ih) below. The present invention further investigates the influence of chirality on the anticancer activity, wherein the enantiomeric pairs of present chiral palladium N-heterocyclic carbene complexes of formula (Ig, Ih) shows no differential activity based on optical isomerism despite all of the palladium complexes exhibiting high anti-proliferative activity towards a variety of cancer cells.
    Type: Application
    Filed: November 8, 2017
    Publication date: July 12, 2018
    Inventors: Anuj Kumar, Afsana Naaz, Prakasham Ayyampudur Palanisamy, Dulal Panda, Prasenjit Ghosh