Abstract: This invention discloses composition and manufacturing processes of a toxicity free botanical drug formulation for relief from breathing difficulties. This botanical drug is manufactured from plants Syzygium aromaticum or component(s) thereof, plant Elettaria cardamomum or component(s) thereof and sweeteners or component(s) thereof. This botanical drug was administered to human volunteers by buccal, supralingual, sublingual and oral routes in effective amount for an effective time-period. Effective amount and effective time of administration varies from one human volunteer to another depending upon type and severity of breathing difficulties.