Patents by Inventor Prameela Susarla
Prameela Susarla has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10131874Abstract: A cell culture support comprising a substrate, and a dual stimuli responsive block copolymer immobilized on the substrate, wherein the dual stimuli responsive block copolymer is both thermoresponsive and pH responsive. A method of culturing cells comprising the cell culture support having a dual stimuli responsive copolymer immobilized on a substrate, wherein the dual stimuli responsive copolymer is thermoresponsive and pH responsive; and growing the cells on the cell culture support. By lowering the temperature, cells are released from the cell culture support.Type: GrantFiled: September 12, 2016Date of Patent: November 20, 2018Assignee: GENERAL ELECTRIC COMPANYInventors: Reginald Donovan Smith, Prameela Susarla, Slawomir Rubinsztajn, Brian David Polizzotti, Anton Beletskii
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Publication number: 20160376550Abstract: A cell culture support comprising a substrate, and a dual stimuli responsive block copolymer immobilized on the substrate, wherein the dual stimuli responsive block copolymer is both thermoresponsive and pH responsive. A method of culturing cells comprising the cell culture support having a dual stimuli responsive copolymer immobilized on a substrate, wherein the dual stimuli responsive copolymer is thermoresponsive and pH responsive; and growing the cells on the cell culture support. By lowering the temperature, cells are released from the cell culture support.Type: ApplicationFiled: September 12, 2016Publication date: December 29, 2016Inventors: Reginald Donovan Smith, Prameela Susarla, Slawomir Rubinsztajn, Brian David Polizzotti, Anton Beletskii
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Patent number: 9469839Abstract: A cell culture support comprising a substrate, and a dual stimuli responsive block copolymer immobilized on the substrate, wherein the dual stimuli responsive block copolymer is both thermoresponsive and pH responsive. A method of culturing cells comprising the cell culture support having a dual stimuli responsive copolymer immobilized on a substrate, wherein the dual stimuli responsive copolymer is thermoresponsive and pH responsive; and growing the cells on the cell culture support. By lowering the temperature, cells are released from the cell culture support.Type: GrantFiled: June 29, 2009Date of Patent: October 18, 2016Assignee: General Electric CompanyInventors: Slawomir Rubinsztajn, Prameela Susarla, Anton Beletskii, Reginald Donovan Smith, Brian Polizzotti
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Patent number: 9453197Abstract: A method of making a carrier for growing cells, including providing a polymer film; embossing a patterned surface one or more sides of the polymer film with an embossing roller; generating a pattern of structured indentations on the polymer film; and discretizing the patterned polymer film into a plurality of portions. The embossing pattern generates relief features on the carrier surface. An alternative method of making a carrier is also provided, including extruding a polymer film; embossing a patterned surface on the polymer film with a roller; generating a pattern of structured indentations on the polymer film; imparting a surface treatment to the film; and discretizing the treated polymer film into a plurality of portions.Type: GrantFiled: November 2, 2011Date of Patent: September 27, 2016Assignee: GENERAL ELECTRIC COMPANYInventors: Yosang Yoon, Slawomir Rubinsztajn, Joel Matthew Caraher, Gary Stephen Balch, Prameela Susarla
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Patent number: 9453196Abstract: A method of culturing adherent cells is provided, wherein the method comprises providing a carrier for growing the cells, comprising one or more surfaces; and one or more relief features/indentations are present on one or more of the surfaces, wherein the carrier has a length at least about 0.2 mm, a width at least about 0.2 mm, and a height in a range from about 0.012 mm to 0.5 mm; and wherein each of the relief features/indentations has a height above the surfaces in a range from about 2 to 200 ?m, and width in a range from about 20 to 200 ?m; seeding the cells on the carriers; and growing the cells on the carrier.Type: GrantFiled: November 2, 2011Date of Patent: September 27, 2016Assignee: GENERAL ELECTRIC COMPANYInventors: Reginald Donovan Smith, Scott Michael Miller, Yosang Yoon, Slawomir Rubinsztajn, Prameela Susarla
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Publication number: 20150337461Abstract: A composition is described, which comprises a crystallizable polyetherimide derived from the polymerization of: (a) a dianhydride component, comprising more than 96.8 mole % of 4,4?-bisphenol A dianhydride or a chemical equivalent thereof; and (b) a diamine component comprising a diamine or a chemical equivalent thereof, wherein the crystallizable polyetherimide has a Tm ranging from 250° C. to 400° C. and the difference between the Tm and Tg of the composition is more than 50° C. Further described are articles, such as fibers, made from the composition, methods for making the composition, methods for making the articles, and methods for using the articles.Type: ApplicationFiled: March 10, 2015Publication date: November 26, 2015Applicant: SABIC GLOBAL TECHNOLOGIES B.V.Inventors: Amitabh Bansal, Thomas Link Guggenheim, Erik C Hagberg, Ganesh Kailasam, Roy Ray Odle, Prameela Susarla, Karthik Venkataraman, Xiaolan Wei
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Patent number: 8993322Abstract: Methods and kits of releasing cells are provided. The method comprises the steps of providing cultured cells on a cell culture support comprising a multi layer polyelectrolyte coating immobilized on a substrate, and releasing the cultured cells from the cell culture support by a releasing solution comprising DMSO. The kit comprises a cell culture support and a releasing solution. The releasing solution comprises DMSO.Type: GrantFiled: February 25, 2013Date of Patent: March 31, 2015Assignee: General Electric CompanyInventors: Slawomir Rubinsztajn, Prameela Susarla, Reginald Donovan Smith, Evelina Roxana Loghin
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Patent number: 8399252Abstract: Methods and kits of releasing cells are provided. The method comprises the steps of providing cultured cells on a cell culture support comprising a multi layer polyelectrolyte coating immobilized on a substrate, and releasing the cultured cells from the cell culture support by a releasing solution comprising DMSO. The kit comprises a cell culture support and a releasing solution. The releasing solution comprises DMSO.Type: GrantFiled: September 30, 2009Date of Patent: March 19, 2013Assignee: General Electric CompanyInventors: Slawomir Rubinsztain, Prameela Susarla, Reginald Donovan Smith, Evelina Roxana Loghin
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Publication number: 20130034669Abstract: A method of making a carrier for growing cells, including providing a polymer film; embossing a patterned surface one or more sides of the polymer film with an embossing roller; generating a pattern of structured indentations on the polymer film; and discretizing the patterned polymer film into a plurality of portions. The embossing pattern generates relief features on the carrier surface. An alternative method of making a carrier is also provided, including extruding a polymer film; embossing a patterned surface on the polymer film with a roller; generating a pattern of structured indentations on the polymer film; imparting a surface treatment to the film; and discretizing the treated polymer film into a plurality of portions.Type: ApplicationFiled: November 2, 2011Publication date: February 7, 2013Applicant: GENERAL ELECTRIC COMPANYInventors: Yosang Yoon, Slawomir Rubinsztajn, Joel Matthew Caraher, Gary Stephen Balch, Prameela Susarla
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Publication number: 20120156772Abstract: In one example of a carrier for growing adherent cells, comprises one or more surfaces; and one or more relief features on one or more of the surfaces, wherein the carrier has a length at least about 0.2 mm, a width at least about 0.2 mm, and a height in a range from about 0.012 mm to 0.5 mm; and wherein each of the relief features has a height in a range from about 2 to 200 ?m, and width in a range from about 20 to 200 ?m.Type: ApplicationFiled: November 2, 2011Publication date: June 21, 2012Applicant: GENERAL ELECTRIC COMPANYInventors: Scott Michael Miller, Yosang Yoon, Slawomir Rubinsztajn, Peter Kennedy Davis, Prameela Susarla
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Publication number: 20120156773Abstract: A method of culturing adherent cells is provided, wherein the method comprises providing a carrier for growing the cells, comprising one or more surfaces; and one or more relief features/indentations are present on one or more of the surfaces, wherein the carrier has a length at least about 0.2 mm, a width at least about 0.2 mm, and a height in a range from about 0.012 mm to 0.5 mm; and wherein each of the relief features/indentations has a height above the surfaces in a range from about 2 to 200 ?m, and width in a range from about 20 to 200 ?m; seeding the cells on the carriers; and growing the cells on the carrier.Type: ApplicationFiled: November 2, 2011Publication date: June 21, 2012Applicant: GENERAL ELECTRIC COMPANYInventors: Reginald Donovan Smith, Scott Michael Miller, Yosang Yoon, Slawomir Rubinsztajn, Prameela Susarla
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Publication number: 20120156777Abstract: A carrier for growing adherent cells is provided, wherein the carrier comprises one or more outer surfaces; and one or more structured indentations on one or more of the outer surfaces, wherein the carrier has a length at least about 0.2 mm, a width at least about 0.2 mm, and a height in a range from about 0.05 mm to 1.2 mm and each of the structured indentations has a major axis in a range from about 0.1 mm to 0.5 mm, a minor axis in a range from about 0.1 mm to 0.5 mm and a depth in a range from about 0.025 mm to about 0.5 mm. The carrier may comprise a single indentation or ‘cup’ like structure, or may comprise a plurality of indentations. A method of making the carrier, and culturing stromal cells using the same carrier are also provided.Type: ApplicationFiled: December 16, 2010Publication date: June 21, 2012Applicant: GENERAL ELECTRIC COMPANYInventors: Arvind Rangarajan, Prameela Susarla, Scott Michael Miller, Reginald Donovan Smith, Slawomir Rubinsztajn, Anton Beletskii
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Publication number: 20120107551Abstract: In one aspect, the present invention provides a preform, comprising: (a) a reinforcing fabric layer; and (b) a polyetherimide fiber incorporated into the reinforcing fabric layer as a stitch thread material. The reinforcing fabric layer comprises less than about 10% by weight polyetherimides. In another aspect, the present invention provides an uncured and a cured composite composition comprising the perform. Articles and method of making the cured composite compositions are also provided.Type: ApplicationFiled: October 28, 2010Publication date: May 3, 2012Applicant: GENERAL ELECTRIC COMPANYInventors: Xiaomei Fang, Wendy Wen-Ling Lin, Prameela Susarla, Jack Allen Woods
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Patent number: 8163847Abstract: A thermoset composition exhibiting reduced water absorption in the cured state includes an olefinically unsaturated monomer and a capped poly(arylene ether) prepared by the reaction of an uncapped poly(arylene ether) with an anhydride capping agent. The capped poly(arylene ether) is isolated and/or purified by methods that reduce the concentrations of polar impurities that contribute to water absorption by the cured composition.Type: GrantFiled: December 10, 2009Date of Patent: April 24, 2012Assignee: Sabic Innovative Plastics IP B.V.Inventors: Kenneth Paul Zarnoch, John Robert Campbell, Amy Rene Freshour, Hua Guo, John Austin Rude, Prameela Susarla, Michael Alan Vallance, Gary William Yeager
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Publication number: 20110076764Abstract: Methods and kits of releasing cells are provided. The method comprises the steps of providing cultured cells on a cell culture support comprising a multi layer polyelectrolyte coating immobilized on a substrate, and releasing the cultured cells from the cell culture support by a releasing solution comprising DMSO. The kit comprises a cell culture support and a releasing solution. The releasing solution comprises DMSO.Type: ApplicationFiled: September 30, 2009Publication date: March 31, 2011Applicant: GENERAL ELECTRIC COMPANYInventors: Slawomir Rubinsztain, Prameela Susarla, Reginald Donova Smith, Evelina Roxana Loghin
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Publication number: 20100330674Abstract: A cell culture support comprising a substrate, and a dual stimuli responsive block copolymer immobilized on the substrate, wherein the dual stimuli responsive block copolymer is both thermoresponsive and pH responsive. A method of culturing cells comprising the cell culture support having a dual stimuli responsive copolymer immobilized on a substrate, wherein the dual stimuli responsive copolymer is thermoresponsive and pH responsive; and growing the cells on the cell culture support. By lowering the temperature, cells are released from the cell culture support.Type: ApplicationFiled: June 29, 2009Publication date: December 30, 2010Applicant: GENERAL ELECTRIC COMPANYInventors: Slawomir Rubinsztajn, Prameela Susarla, Anton Beletskii, Reginald Donovan Smith, Brian Polizzotti
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Patent number: 7781537Abstract: A curable composition includes an olefinically unsaturated monomer and a poly(arylene ether) having two polymerizable groups and an intrinsic viscosity of about 0.05 to about 0.30 deciliters per gram. The composition exhibits an improved combination of high flow during molding and high post-cure stiffness and impact strength. The composition is particularly useful for fabricating plastic-packaged electronic devices.Type: GrantFiled: October 24, 2007Date of Patent: August 24, 2010Assignee: Sabic Innovative Plastics IP B.V.Inventors: Joop Birsak, Herbert Shin-I Chao, Bryan Duffey, Amy Rene Freshour, Hugo Gerard Edward Ingelbrecht, Qiwei Liu, Michael Joseph O'Brien, Prameela Susarla, Michael Vallance, Kenneth Paul Zarnoch
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Publication number: 20100087591Abstract: A thermoset composition exhibiting reduced water absorption in the cured state includes an olefinically unsaturated monomer and a capped poly(arylene ether) prepared by the reaction of an uncapped poly(arylene ether) with an anhydride capping agent. The capped poly(arylene ether) is isolated and/or purified by methods that reduce the concentrations of polar impurities that contribute to water absorption by the cured composition.Type: ApplicationFiled: December 10, 2009Publication date: April 8, 2010Inventors: Kenneth Paul Zarnoch, John Robert Campbell, Amy Rene Freshour, Hua Guo, John Austin Rude, Prameela Susarla, Michael Alan Vallance, Gary William Yeager
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Patent number: 7655734Abstract: A thermoset composition exhibiting reduced water absorption in the cured state includes an olefinically unsaturated monomer and a capped poly(arylene ether) prepared by the reaction of an uncapped poly(arylene ether) with an anhydride capping agent. The capped poly(arylene ether) is isolated and/or purified by methods that reduce the concentrations of polar impurities that contribute to water absorption by the cured composition.Type: GrantFiled: August 28, 2006Date of Patent: February 2, 2010Assignee: Sabic Innovative Plastics IP B.V.Inventors: Kenneth Paul Zarnoch, John Robert Campbell, Amy Rene Freshour, Hua Guo, John Austin Rude, Prameela Susarla, Michael Alan Vallance, Gary William Yeager
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Publication number: 20090075080Abstract: A coated fiber comprising an inner fiber comprising an aramid and an outer coating comprising a polyamic acid or a polyetherimide deposited on the inner fiber is provided. The outer coating comprising the polyamic acid may be subjected to curing to form a polyetherimide coating. Also provided are methods for making the coated fiber wherein the coated fiber comprises an inner fiber comprising an aramid and an outer coating comprising a polyamic acid or a polyetherimide.Type: ApplicationFiled: September 19, 2007Publication date: March 19, 2009Applicant: GENERAL ELECTRIC COMPANYInventors: Rainer Koeniger, Glen David Merfeld, Prameela Susarla, Sameet Jain