Patents by Inventor Prameela Susarla

Prameela Susarla has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10131874
    Abstract: A cell culture support comprising a substrate, and a dual stimuli responsive block copolymer immobilized on the substrate, wherein the dual stimuli responsive block copolymer is both thermoresponsive and pH responsive. A method of culturing cells comprising the cell culture support having a dual stimuli responsive copolymer immobilized on a substrate, wherein the dual stimuli responsive copolymer is thermoresponsive and pH responsive; and growing the cells on the cell culture support. By lowering the temperature, cells are released from the cell culture support.
    Type: Grant
    Filed: September 12, 2016
    Date of Patent: November 20, 2018
    Assignee: GENERAL ELECTRIC COMPANY
    Inventors: Reginald Donovan Smith, Prameela Susarla, Slawomir Rubinsztajn, Brian David Polizzotti, Anton Beletskii
  • Publication number: 20160376550
    Abstract: A cell culture support comprising a substrate, and a dual stimuli responsive block copolymer immobilized on the substrate, wherein the dual stimuli responsive block copolymer is both thermoresponsive and pH responsive. A method of culturing cells comprising the cell culture support having a dual stimuli responsive copolymer immobilized on a substrate, wherein the dual stimuli responsive copolymer is thermoresponsive and pH responsive; and growing the cells on the cell culture support. By lowering the temperature, cells are released from the cell culture support.
    Type: Application
    Filed: September 12, 2016
    Publication date: December 29, 2016
    Inventors: Reginald Donovan Smith, Prameela Susarla, Slawomir Rubinsztajn, Brian David Polizzotti, Anton Beletskii
  • Patent number: 9469839
    Abstract: A cell culture support comprising a substrate, and a dual stimuli responsive block copolymer immobilized on the substrate, wherein the dual stimuli responsive block copolymer is both thermoresponsive and pH responsive. A method of culturing cells comprising the cell culture support having a dual stimuli responsive copolymer immobilized on a substrate, wherein the dual stimuli responsive copolymer is thermoresponsive and pH responsive; and growing the cells on the cell culture support. By lowering the temperature, cells are released from the cell culture support.
    Type: Grant
    Filed: June 29, 2009
    Date of Patent: October 18, 2016
    Assignee: General Electric Company
    Inventors: Slawomir Rubinsztajn, Prameela Susarla, Anton Beletskii, Reginald Donovan Smith, Brian Polizzotti
  • Patent number: 9453197
    Abstract: A method of making a carrier for growing cells, including providing a polymer film; embossing a patterned surface one or more sides of the polymer film with an embossing roller; generating a pattern of structured indentations on the polymer film; and discretizing the patterned polymer film into a plurality of portions. The embossing pattern generates relief features on the carrier surface. An alternative method of making a carrier is also provided, including extruding a polymer film; embossing a patterned surface on the polymer film with a roller; generating a pattern of structured indentations on the polymer film; imparting a surface treatment to the film; and discretizing the treated polymer film into a plurality of portions.
    Type: Grant
    Filed: November 2, 2011
    Date of Patent: September 27, 2016
    Assignee: GENERAL ELECTRIC COMPANY
    Inventors: Yosang Yoon, Slawomir Rubinsztajn, Joel Matthew Caraher, Gary Stephen Balch, Prameela Susarla
  • Patent number: 9453196
    Abstract: A method of culturing adherent cells is provided, wherein the method comprises providing a carrier for growing the cells, comprising one or more surfaces; and one or more relief features/indentations are present on one or more of the surfaces, wherein the carrier has a length at least about 0.2 mm, a width at least about 0.2 mm, and a height in a range from about 0.012 mm to 0.5 mm; and wherein each of the relief features/indentations has a height above the surfaces in a range from about 2 to 200 ?m, and width in a range from about 20 to 200 ?m; seeding the cells on the carriers; and growing the cells on the carrier.
    Type: Grant
    Filed: November 2, 2011
    Date of Patent: September 27, 2016
    Assignee: GENERAL ELECTRIC COMPANY
    Inventors: Reginald Donovan Smith, Scott Michael Miller, Yosang Yoon, Slawomir Rubinsztajn, Prameela Susarla
  • Publication number: 20150337461
    Abstract: A composition is described, which comprises a crystallizable polyetherimide derived from the polymerization of: (a) a dianhydride component, comprising more than 96.8 mole % of 4,4?-bisphenol A dianhydride or a chemical equivalent thereof; and (b) a diamine component comprising a diamine or a chemical equivalent thereof, wherein the crystallizable polyetherimide has a Tm ranging from 250° C. to 400° C. and the difference between the Tm and Tg of the composition is more than 50° C. Further described are articles, such as fibers, made from the composition, methods for making the composition, methods for making the articles, and methods for using the articles.
    Type: Application
    Filed: March 10, 2015
    Publication date: November 26, 2015
    Applicant: SABIC GLOBAL TECHNOLOGIES B.V.
    Inventors: Amitabh Bansal, Thomas Link Guggenheim, Erik C Hagberg, Ganesh Kailasam, Roy Ray Odle, Prameela Susarla, Karthik Venkataraman, Xiaolan Wei
  • Patent number: 8993322
    Abstract: Methods and kits of releasing cells are provided. The method comprises the steps of providing cultured cells on a cell culture support comprising a multi layer polyelectrolyte coating immobilized on a substrate, and releasing the cultured cells from the cell culture support by a releasing solution comprising DMSO. The kit comprises a cell culture support and a releasing solution. The releasing solution comprises DMSO.
    Type: Grant
    Filed: February 25, 2013
    Date of Patent: March 31, 2015
    Assignee: General Electric Company
    Inventors: Slawomir Rubinsztajn, Prameela Susarla, Reginald Donovan Smith, Evelina Roxana Loghin
  • Patent number: 8399252
    Abstract: Methods and kits of releasing cells are provided. The method comprises the steps of providing cultured cells on a cell culture support comprising a multi layer polyelectrolyte coating immobilized on a substrate, and releasing the cultured cells from the cell culture support by a releasing solution comprising DMSO. The kit comprises a cell culture support and a releasing solution. The releasing solution comprises DMSO.
    Type: Grant
    Filed: September 30, 2009
    Date of Patent: March 19, 2013
    Assignee: General Electric Company
    Inventors: Slawomir Rubinsztain, Prameela Susarla, Reginald Donovan Smith, Evelina Roxana Loghin
  • Publication number: 20130034669
    Abstract: A method of making a carrier for growing cells, including providing a polymer film; embossing a patterned surface one or more sides of the polymer film with an embossing roller; generating a pattern of structured indentations on the polymer film; and discretizing the patterned polymer film into a plurality of portions. The embossing pattern generates relief features on the carrier surface. An alternative method of making a carrier is also provided, including extruding a polymer film; embossing a patterned surface on the polymer film with a roller; generating a pattern of structured indentations on the polymer film; imparting a surface treatment to the film; and discretizing the treated polymer film into a plurality of portions.
    Type: Application
    Filed: November 2, 2011
    Publication date: February 7, 2013
    Applicant: GENERAL ELECTRIC COMPANY
    Inventors: Yosang Yoon, Slawomir Rubinsztajn, Joel Matthew Caraher, Gary Stephen Balch, Prameela Susarla
  • Publication number: 20120156772
    Abstract: In one example of a carrier for growing adherent cells, comprises one or more surfaces; and one or more relief features on one or more of the surfaces, wherein the carrier has a length at least about 0.2 mm, a width at least about 0.2 mm, and a height in a range from about 0.012 mm to 0.5 mm; and wherein each of the relief features has a height in a range from about 2 to 200 ?m, and width in a range from about 20 to 200 ?m.
    Type: Application
    Filed: November 2, 2011
    Publication date: June 21, 2012
    Applicant: GENERAL ELECTRIC COMPANY
    Inventors: Scott Michael Miller, Yosang Yoon, Slawomir Rubinsztajn, Peter Kennedy Davis, Prameela Susarla
  • Publication number: 20120156773
    Abstract: A method of culturing adherent cells is provided, wherein the method comprises providing a carrier for growing the cells, comprising one or more surfaces; and one or more relief features/indentations are present on one or more of the surfaces, wherein the carrier has a length at least about 0.2 mm, a width at least about 0.2 mm, and a height in a range from about 0.012 mm to 0.5 mm; and wherein each of the relief features/indentations has a height above the surfaces in a range from about 2 to 200 ?m, and width in a range from about 20 to 200 ?m; seeding the cells on the carriers; and growing the cells on the carrier.
    Type: Application
    Filed: November 2, 2011
    Publication date: June 21, 2012
    Applicant: GENERAL ELECTRIC COMPANY
    Inventors: Reginald Donovan Smith, Scott Michael Miller, Yosang Yoon, Slawomir Rubinsztajn, Prameela Susarla
  • Publication number: 20120156777
    Abstract: A carrier for growing adherent cells is provided, wherein the carrier comprises one or more outer surfaces; and one or more structured indentations on one or more of the outer surfaces, wherein the carrier has a length at least about 0.2 mm, a width at least about 0.2 mm, and a height in a range from about 0.05 mm to 1.2 mm and each of the structured indentations has a major axis in a range from about 0.1 mm to 0.5 mm, a minor axis in a range from about 0.1 mm to 0.5 mm and a depth in a range from about 0.025 mm to about 0.5 mm. The carrier may comprise a single indentation or ‘cup’ like structure, or may comprise a plurality of indentations. A method of making the carrier, and culturing stromal cells using the same carrier are also provided.
    Type: Application
    Filed: December 16, 2010
    Publication date: June 21, 2012
    Applicant: GENERAL ELECTRIC COMPANY
    Inventors: Arvind Rangarajan, Prameela Susarla, Scott Michael Miller, Reginald Donovan Smith, Slawomir Rubinsztajn, Anton Beletskii
  • Publication number: 20120107551
    Abstract: In one aspect, the present invention provides a preform, comprising: (a) a reinforcing fabric layer; and (b) a polyetherimide fiber incorporated into the reinforcing fabric layer as a stitch thread material. The reinforcing fabric layer comprises less than about 10% by weight polyetherimides. In another aspect, the present invention provides an uncured and a cured composite composition comprising the perform. Articles and method of making the cured composite compositions are also provided.
    Type: Application
    Filed: October 28, 2010
    Publication date: May 3, 2012
    Applicant: GENERAL ELECTRIC COMPANY
    Inventors: Xiaomei Fang, Wendy Wen-Ling Lin, Prameela Susarla, Jack Allen Woods
  • Patent number: 8163847
    Abstract: A thermoset composition exhibiting reduced water absorption in the cured state includes an olefinically unsaturated monomer and a capped poly(arylene ether) prepared by the reaction of an uncapped poly(arylene ether) with an anhydride capping agent. The capped poly(arylene ether) is isolated and/or purified by methods that reduce the concentrations of polar impurities that contribute to water absorption by the cured composition.
    Type: Grant
    Filed: December 10, 2009
    Date of Patent: April 24, 2012
    Assignee: Sabic Innovative Plastics IP B.V.
    Inventors: Kenneth Paul Zarnoch, John Robert Campbell, Amy Rene Freshour, Hua Guo, John Austin Rude, Prameela Susarla, Michael Alan Vallance, Gary William Yeager
  • Publication number: 20110076764
    Abstract: Methods and kits of releasing cells are provided. The method comprises the steps of providing cultured cells on a cell culture support comprising a multi layer polyelectrolyte coating immobilized on a substrate, and releasing the cultured cells from the cell culture support by a releasing solution comprising DMSO. The kit comprises a cell culture support and a releasing solution. The releasing solution comprises DMSO.
    Type: Application
    Filed: September 30, 2009
    Publication date: March 31, 2011
    Applicant: GENERAL ELECTRIC COMPANY
    Inventors: Slawomir Rubinsztain, Prameela Susarla, Reginald Donova Smith, Evelina Roxana Loghin
  • Publication number: 20100330674
    Abstract: A cell culture support comprising a substrate, and a dual stimuli responsive block copolymer immobilized on the substrate, wherein the dual stimuli responsive block copolymer is both thermoresponsive and pH responsive. A method of culturing cells comprising the cell culture support having a dual stimuli responsive copolymer immobilized on a substrate, wherein the dual stimuli responsive copolymer is thermoresponsive and pH responsive; and growing the cells on the cell culture support. By lowering the temperature, cells are released from the cell culture support.
    Type: Application
    Filed: June 29, 2009
    Publication date: December 30, 2010
    Applicant: GENERAL ELECTRIC COMPANY
    Inventors: Slawomir Rubinsztajn, Prameela Susarla, Anton Beletskii, Reginald Donovan Smith, Brian Polizzotti
  • Patent number: 7781537
    Abstract: A curable composition includes an olefinically unsaturated monomer and a poly(arylene ether) having two polymerizable groups and an intrinsic viscosity of about 0.05 to about 0.30 deciliters per gram. The composition exhibits an improved combination of high flow during molding and high post-cure stiffness and impact strength. The composition is particularly useful for fabricating plastic-packaged electronic devices.
    Type: Grant
    Filed: October 24, 2007
    Date of Patent: August 24, 2010
    Assignee: Sabic Innovative Plastics IP B.V.
    Inventors: Joop Birsak, Herbert Shin-I Chao, Bryan Duffey, Amy Rene Freshour, Hugo Gerard Edward Ingelbrecht, Qiwei Liu, Michael Joseph O'Brien, Prameela Susarla, Michael Vallance, Kenneth Paul Zarnoch
  • Publication number: 20100087591
    Abstract: A thermoset composition exhibiting reduced water absorption in the cured state includes an olefinically unsaturated monomer and a capped poly(arylene ether) prepared by the reaction of an uncapped poly(arylene ether) with an anhydride capping agent. The capped poly(arylene ether) is isolated and/or purified by methods that reduce the concentrations of polar impurities that contribute to water absorption by the cured composition.
    Type: Application
    Filed: December 10, 2009
    Publication date: April 8, 2010
    Inventors: Kenneth Paul Zarnoch, John Robert Campbell, Amy Rene Freshour, Hua Guo, John Austin Rude, Prameela Susarla, Michael Alan Vallance, Gary William Yeager
  • Patent number: 7655734
    Abstract: A thermoset composition exhibiting reduced water absorption in the cured state includes an olefinically unsaturated monomer and a capped poly(arylene ether) prepared by the reaction of an uncapped poly(arylene ether) with an anhydride capping agent. The capped poly(arylene ether) is isolated and/or purified by methods that reduce the concentrations of polar impurities that contribute to water absorption by the cured composition.
    Type: Grant
    Filed: August 28, 2006
    Date of Patent: February 2, 2010
    Assignee: Sabic Innovative Plastics IP B.V.
    Inventors: Kenneth Paul Zarnoch, John Robert Campbell, Amy Rene Freshour, Hua Guo, John Austin Rude, Prameela Susarla, Michael Alan Vallance, Gary William Yeager
  • Publication number: 20090075080
    Abstract: A coated fiber comprising an inner fiber comprising an aramid and an outer coating comprising a polyamic acid or a polyetherimide deposited on the inner fiber is provided. The outer coating comprising the polyamic acid may be subjected to curing to form a polyetherimide coating. Also provided are methods for making the coated fiber wherein the coated fiber comprises an inner fiber comprising an aramid and an outer coating comprising a polyamic acid or a polyetherimide.
    Type: Application
    Filed: September 19, 2007
    Publication date: March 19, 2009
    Applicant: GENERAL ELECTRIC COMPANY
    Inventors: Rainer Koeniger, Glen David Merfeld, Prameela Susarla, Sameet Jain