Patents by Inventor Pramod Butte
Pramod Butte has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 12324559Abstract: The invention provides systems and methods for imaging a sample. In various embodiments, the invention provides a system comprising an image sensor, a laser for emitting excitation light for an infrared or near-infrared fluorophore, a visible light source, a notch beam splitter, a notch filter, a synchronization module, an image processing unit, an image displaying unit, and light-conducting channels. In various embodiments, the present invention provides a system comprising an image sensor, a laser for emitting excitation light for an infrared or near-infrared fluorophore, a laser clean-up filter, a notch filter, a white light source, an image processing unit, an image displaying unit, and light-conducting channels. In accordance with the present invention, the image sensor can detect both visible light and infrared light.Type: GrantFiled: July 18, 2023Date of Patent: June 10, 2025Assignee: Cedars-Sinai Medical CenterInventors: Pramod Butte, Adam Mamelak
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Patent number: 12152991Abstract: The invention provides systems for characterizing a biological sample by analyzing emission of fluorescent light from the biological sample upon excitation and methods for using the same. The system includes a laser source, collection fibers, a demultiplexer and an optical delay device. All references cited herein are incorporated by reference in their entirety as though fully set forth. Unless defined otherwise, technical and scientific terms used herein have the same meaning as commonly understood by one of-ordinary skill in the art in which this invention belongs.Type: GrantFiled: July 21, 2022Date of Patent: November 26, 2024Assignee: Cedars-Sinai Medical CenterInventors: Pramod Butte, Paul Lapchak, David Scott Kittle
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Patent number: 12025557Abstract: Provided herein are devices, systems, and methods for characterizing a biological sample in vivo or ex vivo in real-time using time-resolved spectroscopy. A light source generates a light pulse or continuous light wave and excites the biological sample, inducing a responsive fluorescent signal. A demultiplexer splits the signal into spectral bands and a time delay is applied to the spectral bands so as to capture data with a detector from multiple spectral bands from a single excitation pulse. The biological sample is characterized by analyzing the fluorescence intensity magnitude and/or decay of the spectral bands. The sample may comprise one or more exogenous or endogenous fluorophore. The device may be a two-piece probe with a detachable, disposable distal end. The systems may combine fluorescence spectroscopy with other optical spectroscopy or imaging modalities. The light pulse may be focused at a single focal point or scanned or patterned across an area.Type: GrantFiled: January 19, 2022Date of Patent: July 2, 2024Assignees: Black Light Surgical, Inc., Cedars-Sinai Medical CenterInventors: Pramod Butte, Keith Black, Jack Kavanaugh, Bartosz Bortnik, Zhaojun Nie
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Patent number: 11737645Abstract: The invention provides systems and methods for imaging a sample. In various embodiments, the invention provides a system comprising an image sensor, a laser for emitting excitation light for an infrared or near-infrared fluorophore, a visible light source, a notch beam splitter, a notch filter, a synchronization module, an image processing unit, an image displaying unit, and light-conducting channels. In various embodiments, the present invention provides a system comprising an image sensor, a laser for emitting excitation light for an infrared or near-infrared fluorophore, a laser clean-up filter, a notch filter, a white light source, an image processing unit, an image displaying unit, and light-conducting channels. In accordance with the present invention, the image sensor can detect both visible light and infrared light.Type: GrantFiled: November 1, 2021Date of Patent: August 29, 2023Assignee: Cedars-Sinai Medical CenterInventors: Pramod Butte, Adam Mamelak
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Publication number: 20230228683Abstract: The invention provides systems for characterizing a biological sample by analyzing emission of fluorescent light from the biological sample upon excitation and methods for using the same. The system includes a laser source, collection fibers, a demultiplexer and an optical delay device. All references cited herein are incorporated by reference in their entirety as though fully set forth. Unless defined otherwise, technical and scientific terms used herein have the same meaning as commonly understood by one of-ordinary skill in the art in which this invention belongs.Type: ApplicationFiled: July 21, 2022Publication date: July 20, 2023Inventors: Pramod Butte, Paul Lapchak, David Scott Kittle
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Patent number: 11630061Abstract: Provided herein are devices, systems, and methods for characterizing a biological sample in vivo or ex vivo in real-time using time-resolved spectroscopy. A light source generates a light pulse or continuous light wave and excites the biological sample, inducing a responsive fluorescent signal. A demultiplexer splits the signal into spectral bands and a time delay is applied to the spectral bands so as to capture data with a detector from multiple spectral bands from a single excitation pulse. The biological sample is characterized by analyzing the fluorescence intensity magnitude and/or decay of the spectral bands. The sample may comprise one or more exogenous or endogenous fluorophore. The device may be a two-piece probe with a detachable, disposable distal end. The systems may combine fluorescence spectroscopy with other optical spectroscopy or imaging modalities. The light pulse may be focused at a single focal point or scanned or patterned across an area.Type: GrantFiled: April 15, 2020Date of Patent: April 18, 2023Assignees: Black Light Surgical, Inc., Cedars-Sinai Medical CenterInventors: Pramod Butte, Keith Black, Jack Kavanaugh, Bartosz Bortnik, Zhaojun Nie
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Publication number: 20220346650Abstract: Disclosed herein are methods of vascular and structural imaging using imaging systems and methods described, the methods comprising producing an image of the vasculature or structure by imaging fluorescence using an imaging system, the system comprising: i) one or more detectors configured to form a fluorescence image of the sample and form a visible image of the sample; ii) a light source configured to emit an excitation light to induce fluorescence from the sample; and iii) a plurality of optics arranged to: direct the excitation light toward the sample; and direct a fluorescent light and a visible light from the sample to the detector; wherein the excitation light and the fluorescence light are directed substantially coaxially.Type: ApplicationFiled: October 1, 2020Publication date: November 3, 2022Inventors: Julia Novak, Teri Dee Koller, Jeffrey Perry, David Kittle, Pramod Butte, Dennis Miller
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Publication number: 20220276167Abstract: Provided herein are devices, systems, and methods for characterizing a biological sample in vivo or ex vivo in real-time using time-resolved spectroscopy. A light source generates a light pulse or continuous light wave and excites the biological sample, inducing a responsive fluorescent signal. A demultiplexer splits the signal into spectral bands and a time delay is applied to the spectral bands so as to capture data with a detector from multiple spectral bands from a single excitation pulse. The biological sample is characterized by analyzing the fluorescence intensity magnitude and/or decay of the spectral bands. The sample may comprise one or more exogenous or endogenous fluorophore. The device may be a two-piece probe with a detachable, disposable distal end. The systems may combine fluorescence spectroscopy with other optical spectroscopy or imaging modalities. The light pulse may be focused at a single focal point or scanned or patterned across an area.Type: ApplicationFiled: January 19, 2022Publication date: September 1, 2022Inventors: Pramod Butte, Keith Black, Jack Kavanaugh, Bartosz Bortnik, Zhaojun Nie
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Patent number: 11428636Abstract: The invention provides systems for characterizing a biological sample by analyzing emission of fluorescent light from the biological sample upon excitation and methods for using the same. The system includes a laser source, collection fibers, a demultiplexer and an optical delay device. All references cited herein are incorporated by reference in their entirety as though fully set forth. Unless defined otherwise, technical and scientific terms used herein have the same meaning as commonly understood by one of-ordinary skill in the art in which this invention belongs.Type: GrantFiled: March 11, 2021Date of Patent: August 30, 2022Assignee: Cedars-Sinai Medical CenterInventors: Pramod Butte, Paul Lapchak, David Scott Kittle
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Patent number: 11195276Abstract: The invention provides systems and methods for imaging a sample. In various embodiments, the invention provides a system comprising an image sensor, a laser for emitting excitation light for an infrared or near-infrared fluorophore, a visible light source, a notch beam splitter, a notch filter, a synchronization module, an image processing unit, an image displaying unit, and light-conducting channels. In various embodiments, the present invention provides a system comprising an image sensor, a laser for emitting excitation light for an infrared or near-infrared fluorophore, a laser clean-up filter, a notch filter, a white light source, an image processing unit, an image displaying unit, and light-conducting channels. In accordance with the present invention, the image sensor can detect both visible light and infrared light.Type: GrantFiled: August 18, 2020Date of Patent: December 7, 2021Assignee: CEDARS-SINAI MEDICAL CENTERInventors: Pramod Butte, Adam Mamelak
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Patent number: 10983060Abstract: The invention provides systems for characterizing a biological sample by analyzing emission of fluorescent light from the biological sample upon excitation and methods for using the same. The system includes a laser source, collection fibers, a demultiplexer and an optical delay device. All references cited herein are incorporated by reference in their entirety as though fully set forth. Unless defined otherwise, technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs.Type: GrantFiled: April 12, 2019Date of Patent: April 20, 2021Assignee: Cedars-Sinai Medical CenterInventors: Pramod Butte, Paul Lapchak, David Scott Kittle
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Patent number: 10803578Abstract: The invention provides systems and methods for imaging a sample. In various embodiments, the invention provides a system comprising an image sensor, a laser for emitting excitation light for an infrared or near-infrared fluorophore, a visible light source, a notch beam splitter, a notch filter, a synchronization module, an image processing unit, an image displaying unit, and light-conducting channels. In various embodiments, the present invention provides a system comprising an image sensor, a laser for emitting excitation light for an infrared or near-infrared fluorophore, a laser clean-up filter, a notch filter, a white light source, an image processing unit, an image displaying unit, and light-conducting channels. In accordance with the present invention, the image sensor can detect both visible light and infrared light.Type: GrantFiled: June 28, 2016Date of Patent: October 13, 2020Assignee: Cedars-Sinai Medical CenterInventors: Pramod Butte, Adam Mamelak
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Publication number: 20200319108Abstract: Provided herein are devices, systems, and methods for characterizing a biological sample in vivo or ex vivo in real-time using time-resolved spectroscopy. A light source generates a light pulse or continuous light wave and excites the biological sample, inducing a responsive fluorescent signal. A demultiplexer splits the signal into spectral bands and a time delay is applied to the spectral bands so as to capture data with a detector from multiple spectral bands from a single excitation pulse. The biological sample is characterized by analyzing the fluorescence intensity magnitude and/or decay of the spectral bands. The sample may comprise one or more exogenous or endogenous fluorophore. The device may be a two-piece probe with a detachable, disposable distal end. The systems may combine fluorescence spectroscopy with other optical spectroscopy or imaging modalities. The light pulse may be focused at a single focal point or scanned or patterned across an area.Type: ApplicationFiled: April 15, 2020Publication date: October 8, 2020Inventors: Pramod Butte, Keith Black, Jack Kavanaugh, Bartosz Bortnik, Zhaojun Nie
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Patent number: 10656089Abstract: Provided herein are devices, systems, and methods for characterizing a biological sample in vivo or ex vivo in real-time using time-resolved spectroscopy. A light source generates a light pulse or continuous light wave and excites the biological sample, inducing a responsive fluorescent signal. A demultiplexer splits the signal into spectral bands and a time delay is applied to the spectral bands so as to capture data with a detector from multiple spectral bands from a single excitation pulse. The biological sample is characterized by analyzing the fluorescence intensity magnitude and/or decay of the spectral bands. The sample may comprise one or more exogenous or endogenous fluorophore. The device may be a two-piece probe with a detachable, disposable distal end. The systems may combine fluorescence spectroscopy with other optical spectroscopy or imaging modalities. The light pulse may be focused at a single focal point or scanned or patterned across an area.Type: GrantFiled: March 31, 2017Date of Patent: May 19, 2020Assignees: Black Light Surgical, Inc., Cedars-Sinai Medical CenterInventors: Pramod Butte, Keith Black, Jack Kavanaugh, Bartosz Bortnik, Zhaojun Nie
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Patent number: 10288567Abstract: The invention provides systems for characterizing a biological sample by analyzing emission of fluorescent light from the biological sample upon excitation and methods for using the same. The system includes a laser source, collection fibers, a demultiplexer and an optical delay device. All references cited herein are incorporated by reference in their entirety as though fully set forth. Unless defined otherwise, technical and scientific tens used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs.Type: GrantFiled: June 29, 2016Date of Patent: May 14, 2019Assignee: Cedars-Sinai Medical CenterInventors: Pramod Butte, Paul Lapchak, David Scott Kittle
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Publication number: 20170367583Abstract: Described herein are methods and systems for analyzing a sample by applying time resolved laser induced fluorescence spectroscopy to the sample to measure lifetime time decay profile data relating to the sample, and applying multivariate analysis to process the data so as to classify a sample as, for example, normal or abnormal. The sample may be cells, fluid or tissue from any organ. The sample may be in vitro or in vivo. The data may be obtained in situ or in vitro.Type: ApplicationFiled: August 22, 2017Publication date: December 28, 2017Inventors: Keith L. Black, Michael Baker, Howland Jones, Pramod Butte
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Publication number: 20160377547Abstract: The invention provides systems for characterizing a biological sample by analyzing emission of fluorescent light from the biological sample upon excitation and methods for using the same. The system includes a laser source, collection fibers, a demultiplexer and an optical delay device. All references cited herein are incorporated by reference in their entirety as though fully set forth. Unless defined otherwise, technical and scientific tens used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs.Type: ApplicationFiled: June 29, 2016Publication date: December 29, 2016Applicant: Cedars-Sinai Medical CenterInventors: Pramod Butte, Paul Lapchak, David Scott Kittle
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Publication number: 20160364858Abstract: The invention provides systems and methods for imaging a sample. In various embodiments, the invention provides a system comprising an image sensor, a laser for emitting excitation light for an infrared or near-infrared fluorophore, a visible light source, a notch beam splitter, a notch filter, a synchronization module, an image processing unit, an image displaying unit, and light-conducting channels. In various embodiments, the present invention provides a system comprising an image sensor, a laser for emitting excitation light for an infrared or near-infrared fluorophore, a laser clean-up filter, a notch filter, a white light source, an image processing unit, an image displaying unit, and light-conducting channels. In accordance with the present invention, the image sensor can detect both visible light and infrared light.Type: ApplicationFiled: June 28, 2016Publication date: December 15, 2016Applicant: Cedars-Sinai Medical CenterInventors: Pramod Butte, Adam Mamelak
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Patent number: 9407838Abstract: The invention provides systems and methods for imaging a sample. In various embodiments, the invention provides a system comprising an image sensor, a laser for emitting excitation light for an infrared or near-infrared fluorophore, a visible light source, a notch beam splitter, a notch filter, a synchronization module, an image processing unit, an image displaying unit, and light-conducting channels. In various embodiments, the present invention provides a system comprising an image sensor, a laser for emitting excitation light for an infrared or near-infrared fluorophore, a laser clean-up filter, a notch filter, a white light source, an image processing unit, an image displaying unit, and light-conducting channels. In accordance with the present invention, the image sensor can detect both visible light and infrared light.Type: GrantFiled: September 8, 2015Date of Patent: August 2, 2016Assignee: Cedars-Sinai Medical CenterInventors: Pramod Butte, Adam Mamelak
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Patent number: 9404870Abstract: The invention provides systems for characterizing a biological sample by analyzing emission of fluorescent light from the biological sample upon excitation and methods for using the same. The system includes a laser source, collection fibers, a demultiplexer and an optical delay device. All references cited herein are incorporated by reference in their entirety as though fully set forth. Unless defined otherwise, technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs.Type: GrantFiled: March 17, 2014Date of Patent: August 2, 2016Assignee: Cedars-Sinai Medical CenterInventors: Pramod Butte, Paul Lapchak, David Scott Kittle