Patents by Inventor Pranhitha Reddy

Pranhitha Reddy has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Fc-Containing Molecules Exhibiting Predictable, Consistent, and Reproducible Glycoform Profiles
    Publication number: 20230235024
    Abstract: The present invention relates to variant Fc-containing molecules, such as antibodies and Fc-fusion molecules, having glycosylation characteristics favorable to large-scale production of therapeutic molecules containing such variant Fc.
    Type: Application
    Filed: July 14, 2022
    Publication date: July 27, 2023
    Applicant: Amgen Inc.
    Inventors: Zhimei DU, Pranhitha REDDY, Randal B. BASS, Feng HE, William C. FANSLOW, III, Yuling ZHANG, Da REN, Randall R. KETCHEM
  • Fc-containing molecules exhibiting predictable, consistent, and reproducible glycoform profiles
    Patent number: 11427627
    Abstract: The present invention relates to variant Fc-containing molecules, such as antibodies and Fc-fusion molecules, having glycosylation characteristics favorable to largescale production of therapeutic molecules containing such variant Fc. Described herein are compositions and methods to improve glycosylation maturation of and to minimize the culture process-dependent effects of Fc-containing molecules, e.g., Fc-fusion molecules and antibodies. Creating single and multiple amino acid substitutions within the Fc domain with the aim to improve high mannose processing and glycosylation maturation.
    Type: Grant
    Filed: September 5, 2014
    Date of Patent: August 30, 2022
    Assignee: Amgen Inc.
    Inventors: Zhimei Du, Pranhitha Reddy, Randal B. Bass, Feng He, William C. Fanslow, III, Yuling Zhang, Da Ren, Randal R. Ketchem
  • METHODS OF USING CELL-CYCLE INHIBITORS TO MODULATE ONE OR MORE PROPERTIES OF A CELL CULTURE
    Publication number: 20180087079
    Abstract: Methods of modulating the properties of a cell culture expressing a protein of interest are provided. In various embodiments the methods relate to the addition of cell cycle inhibitors to growing cell cultures.
    Type: Application
    Filed: November 30, 2017
    Publication date: March 29, 2018
    Applicant: AMGEN INC.
    Inventors: Zhimei DU, John Douglas MCCARTER, Pranhitha REDDY, Andrew William SNOWDEN, Lawrence R. MCGEE, John Gordon ALLEN, David Lawrence TREIBER, Kathleen KEEGAN, Zhihong LI
  • FC-CONTAINING MOLECULES EXHIBITING PREDICTABLE, CONSISTENT, AND REPRODUCIBLE GLYCOFORM PROFILES
    Publication number: 20160207980
    Abstract: The present invention relates to variant Fc-containing molecules, such as antibodies and Fc-fusion molecules, having glycosylation characteristics favorable to largescale production of therapeutic molecules containing such variant Fc. Described herein are compositions and methods to improve glycosylation maturation of and to minimize the culture process-dependent effects of Fc-containing molecules, e.g., Fc-fusion molecules and antibodies. Creating single and multiple amino acid substitutions within the Fc domain with the aim to improve high mannose processing and glycosylation maturation.
    Type: Application
    Filed: September 5, 2014
    Publication date: July 21, 2016
    Applicant: AMGEN INC.
    Inventors: Zhimei DU, Pranhitha REDDY, Randal B. BASS, Feng HE, William C. FANSLOW, III, Yuling ZHANG, Da REN, Randal R. KETCHEM
  • METHODS OF USING CELL-CYCLE INHIBITORS TO MODULATE ONE OR MORE PROPERTIES OF A CELL CULTURE
    Publication number: 20150353542
    Abstract: Methods of modulating the properties of a cell culture expressing a protein of interest are provided. In various embodiments the methods relate to the addition of cell cycle inhibitors to growing cell cultures.
    Type: Application
    Filed: December 11, 2013
    Publication date: December 10, 2015
    Applicant: AMGEN INC.
    Inventors: Zhimei DU, John Douglas MCCARTER, Pranhitha REDDY, Andrew William SNOWDEN, Lawrence R. MCGEE, John Gordon ALLEN, David Lawrence TREIBER, Kathleen KEEGAN, Zhihong LI
  • METHODS OF USING CELL-CYCLE INHIBITORS TO MODULATE ONE OR MORE PROPERTIES OF A CELL CULTURE
    Publication number: 20140199728
    Abstract: Methods of modulating the properties of a cell culture expressing a protein of interest are provided. In various embodiments the methods relate to the addition of cell cycle inhibitors to growing cell cultures.
    Type: Application
    Filed: December 11, 2013
    Publication date: July 17, 2014
    Applicant: AMGEN INC.
    Inventors: Zhimei DU, John Douglas McCARTER, Pranhitha REDDY, Andrew William SNOWDEN, Lawrence R. MCGEE, John Gordon ALLEN, David Lawrence TREIBER, Kathleen KEEGAN, Zhihong LI
  • Trimeric macrophage scavenger receptor fusion proteins and encoding nucleic acids
    Patent number: 7238499
    Abstract: The present invention relates, in part, to a polypeptide domain having reduced immunogenicity that is capable of inducing trimers in heterologous polypeptides, fusion polypeptides comprising the trimer inducing domain, nucleic acids encoding the polypeptides of the invention and methods of making and using the same.
    Type: Grant
    Filed: December 20, 2002
    Date of Patent: July 3, 2007
    Assignee: Immunex Corporation
    Inventor: Pranhitha Reddy
  • Methods and host cells for improved cell culture
    Patent number: 7166445
    Abstract: The invention provides improved methods of recombinant protein production in cell culture. More specifically, the invention relates to the modulation of the IGF-1 signaling pathway in cells so as to improve production characteristics.
    Type: Grant
    Filed: February 28, 2005
    Date of Patent: January 23, 2007
    Assignee: Immunex Corporation
    Inventors: Arvia E. Morris, Pranhitha Reddy
  • Methods and host cells for improved cell culture
    Publication number: 20050170462
    Abstract: The invention provides improved methods of recombinant protein production in cell culture. More specifically, the invention relates to the modulation of the IGF-1 signaling pathway in cells so as to improve production characteristics.
    Type: Application
    Filed: February 28, 2005
    Publication date: August 4, 2005
    Inventors: Arvia Morris, Pranhitha Reddy
  • Methods and host cells for improved cell culture
    Patent number: 6897040
    Abstract: The invention provides improved methods of recombinant protein production in cell culture. More specifically, the invention relates to the modulation of the IGF-1 signaling pathway in cells so as to improve production characteristics.
    Type: Grant
    Filed: March 29, 2002
    Date of Patent: May 24, 2005
    Assignee: Immunex Corporation
    Inventors: Arvia E. Morris, Pranhitha Reddy
  • Methods for producing proteins in cultured cells
    Patent number: 6890736
    Abstract: The invention provides a method for increasing production of a protein by cultured mammalian cells comprising adding a DNA demethylating agent, for example a cytidine analogue, to the mammalian cell culture. The cytidine analogue can be 5-aza-2?-deoxycytidine (also called decitabine) or 5-bromo-2?-deoxycytidine-5?-monophosphate, among many other possible cytidine analogues.
    Type: Grant
    Filed: September 16, 2003
    Date of Patent: May 10, 2005
    Assignee: Immunex Corporation
    Inventors: Pranhitha Reddy, Brian D. Rasmussen
  • Inducers of recombinant protein expression
    Publication number: 20040265964
    Abstract: The invention provides methods of increasing the production of polypeptides, optionally recombinant polypeptides, from mammalian cells using an aromatic carboxylic acid, an acetamide, and/or a hydroxamic acid compound, and cultures containing the same.
    Type: Application
    Filed: April 23, 2004
    Publication date: December 30, 2004
    Inventors: Martin Allen, Pranhitha Reddy, James P. Boyce, Jeffrey N. Fitzner
  • Antibodies that bind the cytokine designated LERK-5
    Patent number: 6596852
    Abstract: LERK-5 polypeptides are disclosed, along with DNA sequences, vectors and transformed host cells useful in producing LERK-5. The LERK-5 polypeptides bind to elk and to hek, which are members of the eph/elk family of receptor tyrosine kinases.
    Type: Grant
    Filed: October 15, 2001
    Date of Patent: July 22, 2003
    Assignee: Immunex Corporation
    Inventors: Douglas P. Cerretti, Pranhitha Reddy
  • Recombinant polypeptides
    Publication number: 20030119149
    Abstract: The present invention relates, in part, to a polypeptide domain having reduced immunogenicity that is capable of inducing trimers in heterologous polypeptides, fusion polypeptides comprising the trimer inducing domain, nucleic acids encoding the polypeptides of the invention and methods of making and using the same.
    Type: Application
    Filed: December 20, 2002
    Publication date: June 26, 2003
    Inventor: Pranhitha Reddy
  • Polynucleotides encoding cytokine designated LERK-5
    Patent number: 6492140
    Abstract: LERK-5 polypeptides are disclosed, along with DNA sequences, vectors and transformed host cells useful in producing LERK-5. The LERK-5 polypeptides bind to elk and to hek, which are members of the eph/elk family of receptor tyrosine kinases.
    Type: Grant
    Filed: January 3, 2001
    Date of Patent: December 10, 2002
    Assignee: Immunex Corporation
    Inventors: Douglas P. Cerretti, Pranhitha Reddy
  • Cytokine designated lerk-5
    Patent number: 6479459
    Abstract: LERK-5 polypeptides are disclosed, along with DNA sequences, vectors and transformed host cells useful in producing LERK-5. The LERK-5 polypeptides bind to elk and to hek, which are members of the eph/elk family of receptor tyrosine kinases.
    Type: Grant
    Filed: October 29, 1996
    Date of Patent: November 12, 2002
    Assignee: Immunex Corporation
    Inventors: Douglas P. Cerretti, Pranhitha Reddy
  • Methods and host cells for improved cell culture
    Publication number: 20020160455
    Abstract: The invention provides improved methods of recombinant protein production in cell culture. More specifically, the invention relates to the modulation of the IGF-1 signaling pathway in cells so as to improve production characteristics.
    Type: Application
    Filed: March 29, 2002
    Publication date: October 31, 2002
    Applicant: Immunex Corporation
    Inventors: Arvia E. Morris, Pranhitha Reddy
  • Antibodies that bind the cytokine designated LERK-5
    Publication number: 20020103358
    Abstract: LERK-5 polypeptides are disclosed, along with DNA sequences, vectors and transformed host cells useful in producing LERK-5. The LERK-5 polypeptides bind to elk and to hek, which are members of the eph/elk family of receptor tyrosine kinases.
    Type: Application
    Filed: October 15, 2001
    Publication date: August 1, 2002
    Applicant: Immunex Corporation
    Inventors: Douglas P. Cerretti, Pranhitha Reddy
  • Methods and host cells for improved cell culture
    Patent number: 6413744
    Abstract: The invention provides improved methods of recombinant protein production in cell culture. More specifically, the invention relates to the modulation of the IGF-1 signaling pathway in cells so as to improve production characteristics.
    Type: Grant
    Filed: August 25, 2000
    Date of Patent: July 2, 2002
    Assignee: Immunex Corporation
    Inventors: Arvia E. Morris, Pranhitha Reddy
  • LERK-5 DNA
    Patent number: 6303769
    Abstract: LERK-5 polypeptides are disclosed, along with DNA sequences, vectors and transformed host cells useful in producing LERK-5. The LERK-5 polypeptides bind to elk and to hek, which are members of the eph/elk family of receptor tyrosine kinases.
    Type: Grant
    Filed: July 8, 1994
    Date of Patent: October 16, 2001
    Assignee: Immunex Corporation
    Inventors: Douglas P. Cerretti, Pranhitha Reddy