Abstract: Embodiments relate to non-invasive medical devices, systems and methods for the detection of anatomical or physiological conditions. In an embodiment, a handheld coronary artery disease (CAD) detection device is used in a non-invasive manner to determine whether an internal coronary artery blockage, calcification or diffuse disease is present. In an embodiment, a data transfer system comprises a hand-held CAD detection device or other data collection device, and a networked or local computer system for storing and processing the recorded data. Supplemental devices such as a data portal device, hub, or dongle can facilitate data transfer between the data collection device and networked or local computer system.