Abstract: The present disclosure relates to a non-transitory computer-readable medium storing computer-executable instructions that, when executed, cause a processor to perform operations, including generating an imaging data set having both scan data and digitized biopsy data from a patient with small cell lung cancer (SCLC). Scan derived features are extracted from the scan data and biopsy derived features are extracted from the digitized biopsy data. A radiomic-pathomic risk score (RPRS) is calculated from one or more of the scan derived features and one or more of the biopsy derived features. The RPRS is indicative of a prognosis of the patient.

Abstract: Various embodiments of the present disclosure are directed towards a method for predicting a response to treatment of small cell lung cancer (SCLC). The method includes generating a radiomic risk score (RRS) for the patient based on a plurality of radiomic features, wherein the RRS is prognostic of overall survival (OS) of the patient. The RRS is provided to a machine learning classifier that is trained to predict a response of the patient to a SCLC chemotherapy treatment based, at least in part, on the RRS. The machine learning classifier provides a classification of the patient into either a responder group (RG) or a non-responder group (NRG), where the NRG indicates the patient will not respond to the SCLC chemotherapy treatment and the RG indicates that the patient will respond to the SCLC chemotherapy treatment.

Abstract: The present disclosure relates to a non-transitory computer-readable medium storing computer-executable instructions that, when executed, cause a processor to perform operations, including generating an imaging data set having both scan data and digitized biopsy data from a patient with small cell lung cancer (SCLC). Scan derived features are extracted from the scan data and biopsy derived features are extracted from the digitized biopsy data. A radiomic-pathomic risk score (RPRS) is calculated from one or more of the scan derived features and one or more of the biopsy derived features. The RPRS is indicative of a prognosis of the patient.