Abstract: In a liquid handling system including a liquid handling substrate having a plurality of channels for conducting a liquid sample in said substrate, where the channels terminate in a plurality of exit ports in an outer surface of the substrate for transfer of a quantity of the liquid sample. The handling system also includes a liquid storage and dispensing substrate having a plurality of separable cartridges corresponding to the channels, with each cartridge terminating at a microelectro mechanical system (MEMS) comprising a laminate of glass, silicon and a piezoelectric substance. The handling system further includes a liquid detecting system comprising a light emitting diode and a photo-detector, where each channel includes a reservoir in communication with a corresponding cartridge creating an interface therebetween.

Abstract: In a liquid handling system including a liquid handling substrate having a plurality of channels for conducting a liquid sample in said substrate, where the channels terminate in a plurality of exit ports in an outer surface of the substrate for transfer of a quantity of the liquid sample. The handling system also includes a liquid storage and dispensing substrate having a plurality of separable cartridges corresponding to the channels, with each cartridge terminating at a microelectro mechanical system (MEMS) comprising a laminate of glass, silicon and a piezoelectric substance. The handling system further includes a liquid detecting system comprising a light emitting diode and a photo-detector, where each channel includes a reservoir in communication with a corresponding cartridge creating an interface therebetween.

Abstract: Disclosed are a method and apparatus for determining whether one or more organic substances, namely, proteins (42) and associated cancer cells (40'), are present in a sample (4a). The method comprises a step of deploying a plurality of fluorescent materials (40) in the tissue sample, individual ones of the plurality of fluorescent materials (40) being selected for coupling to a specific type of substance (42) of interest. The fluorescent materials (40) generally emit characteristic wavelengths in response to being illuminated with excitation light (14a'-14c') having predetermined excitation wavelengths. A next step includes illuminating the sample (4a) with the excitation light (14a'-14c'). The excitation light (14a'-14c') causes any of the fluorescent materials (40) that are disposed within the illuminated portion of the sample (4a), and which are responsive to the excitation wavelengths, to emit their characteristic wavelengths.

Abstract: An improved adaptive optics system is disclosed for correcting atmospheric phase aberrations. A satellite (10) laser beacon is operated at the Stokes shifted Raman wavelength. After passing through the atmosphere (A), the signal is phase conjugated (16) and amplified in the Raman amplifier (12). The result is a high energy laser beam with phase conjugated aberrations which may be returned to the satellite (10).

Abstract: An apparatus and method for the generation of patterns on large optics. A coating layer is deposited on the surface of a large substrate, whereupon a photoresist layer is deposited on the coating layer in relatively small localized areas. A flexible mask is fabricated embodying the pattern to be generated. This flexible mask is then aligned with any desired point on the substrate and brought into contact with the photoresist layer. The photoresist layer is then exposed and each localized area is developed and the underlying coating layer is etched. After the excess photoresist material is washed away the pattern, etched into the coating layer, remains.

Abstract: An apparatus and method for the generation of patterns on large optics. A coating layer is deposited on the surface of a large substrate, whereupon a photoresist layer is deposited on the coating layer in relatively small localized areas. A flexible mask is fabricated embodying the pattern to be generated. This flexible mask is then aligned with any desired point on the substrate and brought into contact with the photoresist layer. The photoresist layer is then exposed and each localized area is developed and the underlying coating layer is etched. After the excess photoresist material is washed away the pattern, etched into the coating layer, remains.

Abstract: An apparatus and method for the generation of patterns on large optics. A coating layer is deposited on the surface of a large substrate, whereupon a photoresist layer is deposited on the coating layer in relatively small localized areas. A flexible mask is fabricated embodying the pattern to be generated. This flexible mask is then aligned with any desired point on the substrate and brought into contact with the photoresist layer. The photoresist layer is then exposed and each localized area is developed and the underlying coating layer is etched. After the excess photoresist material is washed away the pattern, etched into the coating layer, remains.