Patents by Inventor Prasad S. Raje

Prasad S. Raje has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods of synthesis of certain hydroxamic acid compounds
    Patent number: 8642809
    Abstract: The present invention pertains to the general field of chemical synthesis, and more particularly to methods for the synthesis of certain hydroxamic acid compounds, and in particular, (E)-N-hydroxy-3-(3-phenylsulfamoyl-phenyl)-acrylamide, also known as PXD101 and Belinostat®, comprising, for example, the steps of: (SAF) sulfonamide formation; (PURC) optional purification; (AAA) alkenyl-acid addition, comprising: either (i): the steps of, in order: (ACAEA) alkenyl-carboxylic acid ester addition; (PURE) optional purification; and (CAD) carboxylic acid deprotection; or (ii): the step of: (ACAA) alkenyl-carboxylic acid addition; (PURF) optional purification; (HAF) hydroxamic acid formation; and (PURG) optional purification.
    Type: Grant
    Filed: September 23, 2008
    Date of Patent: February 4, 2014
    Assignee: Topotarget UK Ltd.
    Inventors: Helge A. Reisch, Peter Leeming, Prasad S. Raje
  • Methods of Synthesis of Certain Hydroxamic Acid Compounds
    Publication number: 20100286279
    Abstract: The present invention pertains to the general field of chemical synthesis, and more particularly to methods for the synthesis of certain hydroxamic acid compounds, and in particular, (E)-N-hydroxy-3-(3-phenylsulfamoyl-phenyl)-acrylamide, also known as PXD101 and Belinostat®, comprising, for example, the steps of: (SAF) sulfonamide formation; (PURC) optional purification; (AAA) alkenyl-acid addition, comprising: either (i): the steps of, in order: (ACAEA) alkenyl-carboxylic acid ester addition; (PURE) optional purification; and (CAD) carboxylic acid deprotection; or (ii): the step of: (ACAA) alkenyl-carboxylic acid addition; (PURF) optional purification; (HAF) hydroxamic acid formation; and (PURG) optional purification.
    Type: Application
    Filed: September 23, 2008
    Publication date: November 11, 2010
    Applicant: TOPOTARGET UK LIMITED
    Inventors: Helge A. Reisch, Peter Leeming, Prasad S. Raje
  • Process for the preparation of 5-(substituted)-10 methoxy-2,2,4-trimethyl-2,5-dihydro-1H-chromeno [3,4-F] quinolines and derivatives thereof
    Patent number: 6673930
    Abstract: The present invention relates to an efficient process for the preparation of 5-(substituted)-10-methoxy-2,2,4-trimethyl-2,5-dihydro-1H-chromeno[3,4-f]quinolines.
    Type: Grant
    Filed: November 7, 2002
    Date of Patent: January 6, 2004
    Inventors: Yi-Yin Ku, Timothy A. Grieme, Padam N. Sharma, Prasad S. Raje, Howard E. Morton, Mike A. Fitzgerald
  • Process for the preparation of 5-(substituted)-10 methoxy-2,2,4-trimethyl-2,5-dihydro- 1H-chromeno [3,4-f] quinolines and derivatives thereof
    Publication number: 20030069427
    Abstract: The present invention relates to an efficient process for the preparation of 5-(substituted)-10-methoxy-2,2,4-trimethyl-2,5-dihydro-1H-chromeno[3,4-f]quinolines.
    Type: Application
    Filed: November 7, 2002
    Publication date: April 10, 2003
    Inventors: Yi-Yin Ku, Timothy A. Grieme, Padam N. Sharma, Prasad S. Raje, Howard E. Morton, Mike A. Fitzgerald
  • Process for the preparation of 5-(substituted)-10-methoxy-2,2,4-trimethyl-2,5-dihydro-1H-chromeno[3,4-F]quinolines and derivatives thereof
    Patent number: 6518430
    Abstract: The present invention relates to an efficient process for the preparation of 5-(substituted)-10-methoxy-2,2,4-trimethyl-2,5-dihydro-1H-chromeno[3,4-f]quinolines.
    Type: Grant
    Filed: September 21, 2001
    Date of Patent: February 11, 2003
    Assignee: Abbott Laboratories
    Inventors: Yi-Yin Ku, Timothy A. Grieme, Padam N. Sharma, Prasad S. Raje, Howard E. Morton, Mike A. Fitzgerald
  • Process for preparing 6-o-substituted erythromycin derivatives
    Patent number: 6437106
    Abstract: In one aspect, the invention relates to a process for preparing 6-O-substituted erythromycin derivatives comprising reacting 2′-substituted and optionally 4″-substituted 9-oxime erythromycin derivatives with an alkylating agent in the presence of a palladium catalyst and phosphine. In another aspect, the invention relates to processes for preparing 6-O-substituted erythromycin ketolides using the palladium-catalyzed alkylation reaction.
    Type: Grant
    Filed: March 3, 2000
    Date of Patent: August 20, 2002
    Assignee: Abbott Laboratories
    Inventors: Eric J. Stoner, Matthew J. Peterson, Yi-Yin Ku, Russell D. Cink, Arthur J. Cooper, Mahendra N. Deshpande, Tim Grieme, Anthony R. Haight, David R. Hill, Margaret Chi-Ping Hsu, Steven A. King, Marvin Robert Leanna, Elaine C. Lee, Maureen A. McLaughlin, Howard E. Morton, James J. Napier, Daniel J. Plata, Prasad S. Raje, Michael Rasmussen, David Riley, Jien-Heh J. Tien, Steven J. Wittenberger
  • PREPARATION OF AMINO-PROTECTED LYSINE DERIVATIVES
    Publication number: 20020042536
    Abstract: The invention relates to novel processes for preparing differentially protected lysine derivatives via a novel p-anisaldehyde Schiff base intermediate and the intermediate prepared therein.
    Type: Application
    Filed: October 8, 1999
    Publication date: April 11, 2002
    Inventor: PRASAD S. RAJE