Patents by Inventor Prasad V. V. S. V. Manchem

Prasad V. V. S. V. Manchem has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Naphthalene ureas as glucose uptake enhancers
    Patent number: 7071231
    Abstract: Compounds of formula I are useful for treating conditions associated with hyperglycemia, especially Type II diabetes. These compounds are useful in stimulating the kinase activity of the insulin receptor, activating the insulin receptor, and stimulating the uptake of glucose. Pharmaceutical compositions comprising the antidiabetic compounds are also disclosed.
    Type: Grant
    Filed: September 6, 2002
    Date of Patent: July 4, 2006
    Assignee: Telik, Inc.
    Inventors: Wayne R. Spevak, Songyuan Shi, Prasad V. V. S. V. Manchem, Michael R. Kozlowski, Steven R. Schow, Robert T. Lum
  • Naphthylsulfonic acids and related compounds as glucose uptake agonists
    Patent number: 6653321
    Abstract: Methods for treating conditions associated with hyperglycemia, especially Type II diabetes, with novel naphthylsulfonic acids and related compounds. These compounds, as single stereoisomers or mixtures of stereoisomers, or their pharmaceutically acceptable salts, are useful in methods of stimulating the kinase activity of the insulin receptor, enhancing the activation of the insulin receptor by insulin, and stimulating the uptake of glucose into cells. A variety of antidiabetic compounds and pharmaceutical compositions comprising the antidiabetic compounds are also disclosed.
    Type: Grant
    Filed: July 28, 2000
    Date of Patent: November 25, 2003
    Assignee: Telik, Inc.
    Inventors: Wayne R. Spevak, Songyuan Shi, Prasad V. V. S. V. Manchem, Michael R. Kozlowski, Steven R. Schow, Robert T. Lum, Louise Robinson, Jeong Weon Park
  • Benzene tricarboxylic acid derivatives as insulin receptor activators
    Patent number: 6600069
    Abstract: Compounds of Formula I, and pharmaceutical compositions containing these compounds, activate the insulin receptor kinase, which leads to an increased sensitivity to insulin and an increase in glucose uptake, and are therefore useful for the treatment of animals, especially humans, with hyperglycemia, especially for the treatment of type 2 diabetes. Processes for preparation of the compounds, and their use in assays, are also disclosed.
    Type: Grant
    Filed: September 6, 2001
    Date of Patent: July 29, 2003
    Assignee: Telik, Inc.
    Inventors: Louise Robinson, Prasad V. V. S. V. Manchem, Nicolas Cairns, Steven R. Schow
  • Novel naphthalene ureas as glucose uptake enhancers
    Publication number: 20030135063
    Abstract: Compounds of formula I are useful for treating conditions associated with hyperglycemia, especially Type II diabetes. These compounds are useful in stimulating the kinase activity of the insulin receptor, activating the insulin receptor, and stimulating the uptake of glucose. Pharmaceutical compositions comprising the antidiabetic compounds are also disclosed.
    Type: Application
    Filed: September 6, 2002
    Publication date: July 17, 2003
    Inventors: Wayne R. Spevak, Songyuan Shi, Prasad V.V.S.V. Manchem, Michael R. Kozlowski, Steven R. Schow, Robert T. Lum
  • Method for determining whether a compound is an insulin receptor kinase activator
    Patent number: 6528037
    Abstract: A method for determining whether a compound is an insulin receptor kinase activator.
    Type: Grant
    Filed: April 2, 2002
    Date of Patent: March 4, 2003
    Assignee: Telik, Inc.
    Inventors: Prasad V. V. S. V. Manchem, Robert T. Lum, Steven R. Schow
  • Method for determining whether a compound is an insulin receptor kinase activator
    Publication number: 20020151542
    Abstract: A method for determining whether a compound is an insulin receptor kinase activator.
    Type: Application
    Filed: April 2, 2002
    Publication date: October 17, 2002
    Inventors: Prasad V.V.S.V. Manchem, Robert T. Lum, Steven R. Schow
  • Naphthalene ureas as glucose uptake enhancers
    Patent number: 6458998
    Abstract: Compounds of formula I are useful for treating conditions associated with hyperglycemia, especially Type II diabetes. These compounds are useful in stimulating the kinase activity of the insulin receptor, activating the insulin receptor, and stimulating the uptake of glucose. Pharmaceutical compositions comprising the antidiabetic compounds are also disclosed.
    Type: Grant
    Filed: May 25, 2000
    Date of Patent: October 1, 2002
    Assignee: Telik, Inc.
    Inventors: Wayne R. Spevak, Songyuan Shi, Prasad V. V. S. V. Manchem, Michael R. Kozlowski, Steven R. Schow, Robert T. Lum
  • Benzene tricarboxylic acid derivatives as insulin receptor activators
    Publication number: 20020103183
    Abstract: Compounds of Formula I, and pharmaceutical compositions containing these compounds, activate the insulin receptor kinase, which leads to an increased sensitivity to insulin and an increase in glucose uptake, and are therefore useful for the treatment of animals, especially humans, with hyperglycemia, especially for the treatment of type 2 diabetes. Processes for preparation of the compounds, and their use in assays, are also disclosed.
    Type: Application
    Filed: September 6, 2001
    Publication date: August 1, 2002
    Inventors: Louise Robinson, Prasad V.V.S.V. Manchem, Nicolas Cairns, Steven R. Schow
  • Insulin receptor activators for the treatment of metabolic disorders induced by treatment with HIV protease inhibitors
    Publication number: 20020061927
    Abstract: Methods of treating a person suffering from HIV protease inhibitor-induced metabolic disorders such as lipodystrophy, hypertriglyceridemia, insulin resistance, hyperglycemia, diabetes and ketoacidosis, comprise treatment with an insulin receptor activating compound, optionally in conjunction with insulin. In general, any insulin receptor activating compound is suitable for the practice of the invention; and preferred compounds are disclosed.
    Type: Application
    Filed: October 11, 2001
    Publication date: May 23, 2002
    Inventors: Prasad V.V.S.V. Manchem, Robert T. Lum, Steven R. Schow