Abstract: Provided herein are methods comprising the use of KRAS (e.g., hKRAS) inhibitors in combination with an agent(s) that specifically binds to EGFR (e.g., hEGFR) and TGF? (e.g., hTGF?), as well as compositions and kits comprising the same. The methods provided herein are useful in methods of treating cancer, (e.g., KRAS (e.g., hKRAS) variant cancers). Further provided herein are combination regimens, combination compositions, pharmaceutical compositions, and kits comprising a KRAS (e.g., hKRAS) inhibitor and an agent(s) that specifically binds to EGFR (e.g., hEGFR) and TGF? (e.g., hTGF?).

Abstract: Provided herein are methods of treating cancer by administering to a subject having cancer an antibody, or functional fragment or functional variant thereof, that specifically binds programmed cell death protein 1 (PD1); and a fusion protein that comprises a targeting moiety and an immunomodulatory moiety, wherein: i) said targeting moiety specifically binds epidermal growth factor receptor (EGFR); and (ii) said immunomodulatory moiety comprises an amino acid sequence of the extracellular domain of transforming growth factor-beta receptor II (TGF?RII).

Abstract: Provided is a dishwashing detergent composition, which includes a quaternary ammonium salt and a ware cleaning formulation, and method of making and using thereof. In particular, the quaternary ammonium salts may have a structure of [NR1R2R3R4]+.X? wherein each of R1, R2, R3, and R4 is independently selected from the group consisting of hydrogen, C1-C10 alkyl, H—(OCH2CH2)m—, RTCOO(CH2)n—, RTCONH(CH2)n—, and RT; at least one of R1, R2, R3, and R4 is RTCOO(CH2)n—, RTCONH(CH2)n—, and RT; n is 1, 2, 3, 4, or 5; m is at least 1; RT is a C10-C30 saturated or unsaturated hydrocarbon chain; and X is a counterion.

Abstract: A tablet including a dishwashing detergent composition and a crosslinked acrylic acid polymer having a weight average molecular weight (Mw) of at least 500,000.

Abstract: A tablet including a dishwashing detergent composition and a crosslinked acrylic acid polymer having a weight average molecular weight (Mw) of at least 500,000.

Abstract: A tablet including a dishwashing detergent composition and a crosslinked acrylic acid polymer having a weight average molecular weight (Mw) of at least 500,000.

Abstract: Provided are scale-inhibition compositions comprising (a) a first acrylic acid polymer having an average molecular weight of about 3000 to about 6000; (b) a second acrylic acid polymer having an average molecular weight of about 6000 to about 10000; (c) an aminocarboxylic acid selected from methylglycine diacetic acid (MGDA), glutamic acid diacetic acid (GLDA), diethylene triamine pentaacetic acid (DTPA), hydroxyethyl ethylene diamine triacetic acid (HEDTA), ethylenediaminetetraacetic acid (EDTA), and a combination thereof; and (d) a phosphonic acid selected from 1-hydroxyethane 1,1-diphosphonic acid (HEDP), amino tris(methylenephosphonic acid) (ATMP), ethylenediamine tetra(methylene phosphonic acid) (EDTMP), tetramethylenediamine tetra(methylene phosphonic acid) (TDTMP), hexamethylenediamine tetra(methylene phosphonic acid) (HDTMP), diethylenetriamine penta(methylene phosphonic acid) (DTPMP), and a combination thereof.

Abstract: A tablet including a dishwashing detergent composition and a crosslinked acrylic acid polymer having a weight average molecular weight (Mw) of at least 500,000.

Abstract: Provided is a dishwashing detergent composition, which includes a quaternary ammonium salt and a ware cleaning formulation, and method of making and using thereof. In particular, the quaternary ammonium salts may have a structure of [NR1R2R3R4]?.X?, wherein each of R1, R2, R3, and R4 is independently selected from the group consisting of hydrogen, C1-C10 alkyl, H—(OCH2CH2)m—, RTCOO(CH2)n—, RTCONH(CH2)n—, and RT; at least one of R1, R2, R3, and R4 is RTCOO(CH2)n—, RTCONH(CH2)n—, or RT; n is 1, 2, 3, 4, or 5; m is at least 1; RT is a C10-C30 saturated or unsaturated hydrocarbon chain; and X is a counterion.

Abstract: Provided are scale-inhibition compositions comprising (a) a first acrylic acid polymer having an average molecular weight of about 3000 to about 6000; (b) a second acrylic acid polymer having an average molecular weight of about 6000 to about 10000; (c) an aminocarboxylic acid selected from methylglycine diacetic acid (MGDA), glutamic acid diacetic acid (GLDA), diethylene triamine pentaacetic acid (DTPA), hydroxyethyl ethylene diamine triacetic acid (HEDTA), ethylenediaminetetraacetic acid (EDTA), and a combination thereof; and (d) a phosphonic acid selected from from 1-hydroxyethane 1,1-diphosphonic acid (HEDP), amino tris(methylenephosphonic acid) (ATMP), ethylenediamine tetra(methylene phosphonic acid) (EDTMP), tetramethylenediamine tetra(methylene phosphonic acid) (TDTMP), hexamethylenediamine tetra(methylene phosphonic acid) (HDTMP), diethylenetriamine penta(methylene phosphonic acid) (DTPMP), and a combination thereof.

Abstract: Provided are scale-inhibition compositions comprising (a) a first acrylic acid polymer having an average molecular weight of about 3000 to about 6000; (b) a second acrylic acid polymer having an average molecular weight of about 6000 to about 10000; (c) an aminocarboxylic acid selected from methylglycine diacetic acid (MGDA), glutamic acid diacetic acid (GLDA), diethylene triamine pentaacetic acid (DTPA), hydroxyethyl ethylene diamine triacetic acid (HEDTA), ethylenediaminetetraacetic acid (EDTA), and a combination thereof; and (d) a phosphonic acid selected from 1-hydroxyethane 1,1-diphosphonic acid (HEDP), amino tris(methylenephosphonic acid) (ATMP), ethylenediamine tetra(methylene phosphonic acid) (EDTMP), tetramethylenediamine tetra(methylene phosphonic acid) (TDTMP), hexamethylenediamine tetra(methylene phosphonic acid) (HDTMP), diethylenetriamine penta(methylene phosphonic acid) (DTPMP), and a combination thereof.