Patents by Inventor Prashanth Hosabettu Mohan
Prashanth Hosabettu Mohan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230212499Abstract: The bioprocessing perfusion system (10) includes a bioreactor (12) and a feed flow path (14). A first tangential flow filter (16) is coupled to the bioreactor (12) via the feed flow path (14) and a second tangential flow filter (18) is coupled to the bioreactor (12) via the feed flow path (14). The first tangential flow filter (16) is a microfiltration-type filter and the second tangential flow filter (18) is an ultrafiltration-type filter. The first tangential flow filter (16) and the second tangential flow filter (18) are further coupled to a receiving unit (58) via the permeate flow path (60). The first tangential flow filter (16) and the second tangential flow filter (18) are further coupled to the bioreactor (12) via the retentate flow path (46).Type: ApplicationFiled: July 13, 2021Publication date: July 6, 2023Inventors: Sahebagouda Alagur, Prashanth Hosabettu Mohan, Praveen Paul
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Publication number: 20230031710Abstract: Systems (700) and methods (800) for method of continuous fluid flow in a bioreactor (700) is provided. The method (800) comprises providing (805) a bioreactor system (700) including a bioreactor volume (720), a filtration part (730), and a recirculation line (721) including a recirculation pump (722) is provided between the bioreactor volume (720) and the filtration part (730). The method (800) further comprises providing (810) a plurality of sensors (760) along the recirculation line (721) and monitoring the fluid flow parameters using the sensors (760). The method further comprises sending (820) a plurality of signals from the sensors (760) indicative of the fluid flow parameters to one or more controllers; and controlling (830) the fluid flow rate at the recirculation pump (722) by means of the or each controller.Type: ApplicationFiled: December 17, 2020Publication date: February 2, 2023Inventors: Praveen Paul, Sahebagouda Alagur, Thomas Falkman, Prashanth Hosabettu Mohan
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Patent number: 11415241Abstract: A valve (100) for a bioprocess liquid apparatus (199) comprises tubular sections (101, 102, 103) inside which valve seat means (155) are arranged. A plunger arrangement (150) is configured to selectively interact with the valve seat means to close and open the tubular sections in response to a magnetic field provided by solenoid arrangements (104, 105), the solenoid arrangements being arranged at the bioprocess liquid apparatus. A flow path device comprising such a valve and a bioprocess liquid apparatus and a method of handling a bioprocess liquid are also disclosed.Type: GrantFiled: July 19, 2019Date of Patent: August 16, 2022Assignee: Cytiva Sweden ABInventors: Prashanth Hosabettu Mohan, Ajit S. Vernekar, Praveen Paul, Krishnadev Madhavan Nair, Manjunath Bhat
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Patent number: 11359176Abstract: A microfluidic device (100) is disclosed for in-process monitoring of cell culture conditions including for example one or more of: cell density; cell viability; secreted proteins; protein analysis; epitope markers; concentrations of metabolites or nutrients and antigenic determinations; the device comprising: a cell inlet path (120); plural fluid reservoirs (130) in fluid communication with the cell input path, a cell analysis area (160) in fluid communication with the path and reservoirs, and a waste storage volume (166) also in fluid communication with the cell analysis area, the device being operable to cause a primary fluid flow along the inlet path to the analysis area, and to selectively cause secondary fluid flow(s) into the path from none, one or more of the selected reservoirs to combine, if one or more of the reservoirs are selected, with the primary fluid flow from the cell inlet path, in each case for analysis at the cell analysis area, the device being further operable to cause a fluid flow of tType: GrantFiled: June 22, 2017Date of Patent: June 14, 2022Assignee: GLOBAL LIFE SCIENCES SOLUTIONS USA LLCInventors: Prashanth Hosabettu Mohan, Sandip Maity, Nagapriya Kavoori Sethumadhavan, Swapnil Puranik, Li Ou, Nagaraju Konduru
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Publication number: 20210395664Abstract: A perfusion bioprocessing system (10) includes a bioreactor (12) and a recirculation flow path (14) provided with at least in one first feed flow control device (46) and at least one second feed control device (48). The perfusion bioprocessing system (10) further includes a first tangential flow filter (16) coupled to the bioreactor (12) via the recirculation flow path (14) and a second tangential flow filter (18) coupled to the bioreactor (12) via the recirculation flow path (14). The first tangential flow filter and the second tangential flow filter are coupled to a permeate flow path and a retentate flow path. Additionally, the perfusion bioprocessing system (10) includes a control unit (90) coupled to the at least one first feed flow control device (38) and the at least one second feed control device (40).Type: ApplicationFiled: September 20, 2019Publication date: December 23, 2021Inventors: Praveen Paul, Prashanth Hosabettu Mohan, Ajay Gore, Sahebagouda Alagur
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Publication number: 20210261900Abstract: A method includes inducing a first quantity of a feed fluid (28) to flow along a first direction (72) from a bioreactor (12) to a tangential flow filter (16) to separate the first quantity of the feed fluid (28) into a permeate fluid (42) and a retentate fluid (48). Further, the control unit (66) is operated to control at least one feed flow control device (24, 26) to inhibit the flow of first quantity of the feed fluid (28). Furthermore, the control unit (66) is operated to control the at least one feed flow control device (24, 26) to direct at least one of further flow of a second quantity of the feed fluid (28) from the bioreactor (12), a portion of the permeate fluid (42), and a portion of a nutrient fluid, along a second direction (74) opposite to the first direction (72) via the tangential flow filter (16).Type: ApplicationFiled: August 20, 2019Publication date: August 26, 2021Inventors: Anoop Bhargav, Praveen Paul, Prashanth Hosabettu Mohan, Ajay Gore, Pradeep Kumar, Victor Jose, Sahebagouda Alagur, Melissa Marie Semple, Mark David Roberts
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Publication number: 20210140558Abstract: A valve (100) for a bioprocess liquid apparatus (199) comprises tubular sections (101, 102, 103) inside which valve seat means (155) are arranged. A plunger arrangement (150) is configured to selectively interact with the valve seat means to close and open the tubular sections in response to a magnetic field provided by solenoid arrangements (104, 105), the solenoid arrangements being arranged at the bioprocess liquid apparatus. A flow path device comprising such a valve and a bioprocess liquid apparatus and a method of handling a bioprocess liquid are also disclosed.Type: ApplicationFiled: July 19, 2019Publication date: May 13, 2021Inventors: Prashanth Hosabettu Mohan, Ajit S. Vernekar, Praveen Paul, Krishnadev Madhavan Nair, Manjunath Bhat
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Publication number: 20200282361Abstract: The invention discloses embodiments of different high precision pinch control valves having an accuracy in the micron range and a method of controlling a transmembrane pressure (TMP) in a crossflow filtration apparatus, comprising the steps of: a) providing a crossflow filtration apparatus comprising a pump (21) fluidically connected via a retentate compartment (33) of a crossflow filter (32) and a length of flexible tubing to Sa regulator valve (1;101) acting on the flexible tubing, wherein the regulator valve is a high precision pinch valve.Type: ApplicationFiled: February 21, 2017Publication date: September 10, 2020Inventors: Klaus Gebauer, Sudheer Mygapula, Nachiket Karmarkar, Sasikumar Arumugam, Bashkar HV, Ajit S. Vernekar, Nityananda Maiya, Prashanth Hosabettu Mohan, Sasi Kumar Nutalapati, Sameera Simha Hindupur, Shashidhar Hedge
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Publication number: 20200181560Abstract: A microfluidic device (100) is disclosed for in-process monitoring of cell culture conditions including for example one or more of: cell density; cell viability; secreted proteins; protein analysis; epitope markers; concentrations of metabolites or nutrients and antigenic determinations; the device comprising: a cell inlet path (120); plural fluid reservoirs (130) in fluid communication with the cell input path, a cell analysis area (160) in fluid communication with the path and reservoirs, and a waste storage volume (166) also in fluid communication with the cell analysis area, the device being operable to cause a primary fluid flow along the inlet path to the analysis area, and to selectively cause secondary fluid flow(s) into the path from none, one or more of the selected reservoirs to combine, if one or more of the reservoirs are selected, with the primary fluid flow from the cell inlet path, in each case for analysis at the cell analysis area, the device being further operable to cause a fluid flow of tType: ApplicationFiled: June 22, 2017Publication date: June 11, 2020Applicant: General Electric CompanyInventors: Prashanth Hosabettu Mohan, Sandip Maity, Nagapriya Kavoori Sethumadhavan, Swapnil Puranik, Li Ou
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Patent number: 10625210Abstract: A method and a system for improving mixing of content in a container 3 provided in a filter system 1, said method comprising providing a mixing loop 13 parallel to a recirculation flow path 11 of the filter system 1.Type: GrantFiled: October 28, 2016Date of Patent: April 21, 2020Assignee: GE Healthcare Bio-Sciences ABInventors: Klaus Gebauer, Partha Sarathy Doddapadam Srinivasa Raghavachar, Narendra G R, Nachiket Karmarkar, Ajit S. Vernekar, Prashanth Hosabettu Mohan, Sasi Kumar Nutalapati
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Publication number: 20180304199Abstract: A method and a system for improving mixing of content in a container 3 provided in a filter system 1, said method comprising providing a mixing loop 13 parallel to a recirculation flow path 11 of the filter system 1.Type: ApplicationFiled: October 28, 2016Publication date: October 25, 2018Inventors: Klaus Gebauer, Partha Sarathy Doddapadam Srinivasa Raghavachar, Narendra G R, Nachiket Karmarkar, Ajit S. Vernekar, Prashanth Hosabettu Mohan, Sasi Kumar Nutalapati
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Patent number: 10081135Abstract: An integrated system for fusing and sealing of a plurality of tubes is disclosed. The integrated system includes one or more fusing units configured to cut one or more tubes of multiple tubes simultaneously, and fusing the one or more tubes together along their respective cut ends; one or more sealing units configured to seal an end of the tube of the multiple tubes; and a control unit for controlling functions of the one or more fusing units and the one or more sealing units.Type: GrantFiled: February 19, 2015Date of Patent: September 25, 2018Assignee: GE HEALTHCARE BIO-SCIENCES ABInventors: Haresh Digambar Patil, Partha Sarathy Doddapadam Srinivasa Raghavachar, Ganesan Mariyappan, Prashanth Hosabettu Mohan
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Publication number: 20170113402Abstract: An integrated system for fusing and sealing of a plurality of tubes is disclosed. The integrated system includes one or more fusing units configured to cut one or more tubes of multiple tubes simultaneously, and fusing the one or more tubes together along their respective cut ends; one or more sealing units configured to seal an end of the tube of the multiple tubes; and a control unit for controlling functions of the one or more fusing units and the one or more sealing units.Type: ApplicationFiled: February 19, 2015Publication date: April 27, 2017Inventors: Haresh Digambar Patil, Partha Sarathy Doddapadam Srinivasa Raghavachar, Ganesan Mariyappan, Prashanth Hosabettu Mohan