Abstract: The present invention relates to the stable liquid pharmaceutical composition comprising (a) cabazitaxel or a pharmaceutically acceptable salt or solvate thereof, (b) one or more solubilizers selected from the group consisting of soya phosphatidyl choline, polyethylene glycol and glycocholic acid, (c) a solvent and (d) a co-solvent, wherein the pharmaceutical composition is substantially free of (i) polysorbates and (ii) stabilizers selected from the group consisting of preservatives, antioxidants and chelating agents and the process for preparation thereof, and the methods of using the stable liquid pharmaceutical composition of cabazitaxel for the treatment of patients with hormone refractory metastatic prostate cancer previously treated with a docetaxel containing treatment regimen.

Abstract: A method of alerting the driver of a vehicle to a lane departure condition. The method includes operating a lane detection system to detect that the vehicle is experiencing a lane departure condition, operating a sensor to detect background vibration experienced by the vehicle, determining a characteristic making a haptic signal likely to be distinguishable from the background vibration, and operating a haptic signal generator in response to the lane departure condition to deliver to a driver the haptic signal having the characteristic.

Abstract: A method of alerting the driver of a vehicle to a lane departure condition. The method includes operating a lane detection system to detect that the vehicle is experiencing a lane departure condition, operating a sensor to detect background vibration experienced by the vehicle, determining a characteristic making a haptic signal likely to be distinguishable from the background vibration, and operating a haptic signal generator in response to the lane departure condition to deliver to a driver the haptic signal having the characteristic.