Patents by Inventor Prashanth Vishwanath
Prashanth Vishwanath has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Publication number: 20230242923Abstract: Engineered polypeptides useful in synthesizing acyl amino acids are provided. Also provided are methods of making acyl amino acids using engineered polypeptides. In certain embodiments, an acyl amino acid produced using compositions and/or methods at the present invention comprises cocoyl glutamate.Type: ApplicationFiled: December 8, 2022Publication date: August 3, 2023Inventors: Kevin A. Jarrell, Prashanth Vishwanath, Gabriel Oscar Reznik
-
Publication number: 20230220016Abstract: The disclosure provides amino acid sequence variants of Bacillus thuringiensis (Bt) toxins and methods of producing the same. Some aspects of this disclosure provide methods for generating Bt toxin variants by continuous directed evolution. Some aspects of this disclosure provide compositions and methods for pest control using the disclosed variant Bt toxins.Type: ApplicationFiled: October 26, 2022Publication date: July 13, 2023Applicants: President and Fellows of Harvard College, Monsanto CompanyInventors: David R. Liu, Ahmed Hussein Badran, Victor Guzov, Tom Malvar, Prashanth Vishwanath, Jeff Nageotte, Qing Huai, Melissa Kemp
-
Patent number: 11524983Abstract: The disclosure provides amino acid sequence variants of Bacillus thuringiensis (Bt) toxins and methods of producing the same. Some aspects of this disclosure provide methods for generating Bt toxin variants by continuous directed evolution. Some aspects of this disclosure provide compositions and methods for pest control using the disclosed variant Bt toxins.Type: GrantFiled: July 22, 2016Date of Patent: December 13, 2022Assignees: President and Fellows of Harvard College, Monsanto CompanyInventors: David R. Liu, Ahmed Hussein Badran, Victor Guzov, Tom Malvar, Prashanth Vishwanath, Jeff Nageotte, Qing Huai, Melissa Kemp
-
Publication number: 20220259626Abstract: In certain embodiments, the present invention comprises compositions and methods useful in the generation of acyl amino acids. In certain embodiments, the present invention provides an engineered polypeptide comprising a peptide synthetase domain; in some such embodiments, the engineered polypeptide comprises only a single peptide synthetase domain. In some embodiments, the present invention provides an engineered peptide synthetase that is substantially free of a thioesterase domain, and/or a reductase domain. In certain embodiments, the present invention provides an acyl amino acid composition comprising a plurality of different forms of an acyl amino acid. In some such compositions, substantially all of the acyl amino acids within the composition contain the same amino acid moiety and differ with respect to acyl moiety. We also described populations where the fatty acid is for example 95% one length (C14, myristic).Type: ApplicationFiled: September 21, 2021Publication date: August 18, 2022Inventors: Kevin A. Jarrell, Gabriel O. Reznik, Prashanth Vishwanath, Michelle Pynn
-
Patent number: 11155843Abstract: In certain embodiments, the present invention comprises compositions and methods useful in the generation of acyl amino acids. In certain embodiments, the present invention provides an engineered polypeptide comprising a peptide synthetase domain; in some such embodiments, the engineered polypeptide comprises only a single peptide synthetase domain. In some embodiments, the present invention provides an engineered peptide synthetase that is substantially free of a thioesterase domain, and/or a reductase domain. In certain embodiments, the present invention provides an acyl amino acid composition comprising a plurality of different forms of an acyl amino acid. In some such compositions, substantially all of the acyl amino acids within the composition contain the same amino acid moiety and differ with respect to acyl moiety. We also described populations where the fatty acid si for example 95% one length (C14, myristic).Type: GrantFiled: March 18, 2020Date of Patent: October 26, 2021Assignee: Modular Genetics, Inc.Inventors: Kevin A. Jarrell, Gabriel O. Reznik, Prashanth Vishwanath, Michelle Pynn
-
Publication number: 20210062234Abstract: In certain embodiments, the present invention comprises compositions and methods useful in the generation of acyl amino acids. In certain embodiments, the present invention provides an engineered polypeptide comprising a peptide synthetase domain; in some such embodiments, the engineered polypeptide comprises only a single peptide synthetase domain. In some embodiments, the present invention provides an engineered peptide synthetase that is substantially free of a thioesterase domain, and/or a reductase domain. In certain embodiments, the present invention provides an acyl amino acid composition comprising a plurality of different forms of an acyl amino acid. In some such compositions, substantially all of the acyl amino acids within the composition contain the same amino acid moiety and differ with respect to acyl moiety. We also described populations where the fatty acid si for example 95% one length (C14, myristic).Type: ApplicationFiled: March 18, 2020Publication date: March 4, 2021Inventors: Kevin A. Jarrell, Gabriel O. Reznik, Prashanth Vishwanath, Michelle Pynn
-
Patent number: 10640799Abstract: In certain embodiments, the present invention comprises compositions and methods useful in the generation of acyl amino acids. In certain embodiments, the present invention provides an engineered polypeptide comprising a peptide synthetase domain; in some such embodiments, the engineered polypeptide comprises only a single peptide synthetase domain. In some embodiments, the present invention provides an engineered peptide synthetase that is substantially free of a thioesterase domain, and/or a reductase domain. In certain embodiments, the present invention provides an acyl amino acid composition comprising a plurality of different forms of an acyl amino acid. In some such compositions, substantially all of the acyl amino acids within the composition contain the same amino acid moiety and differ with respect to acyl moiety. We also described populations where the fatty acid si for example 95% one length (C14, myristic).Type: GrantFiled: May 14, 2018Date of Patent: May 5, 2020Assignee: Modular Genetics, Inc.Inventors: Kevin A. Jarrell, Gabriel O. Reznik, Prashanth Vishwanath, Michelle Pynn
-
Publication number: 20190062759Abstract: Engineered polypeptides useful in synthesizing acyl amino acids are provided. Also provided are methods of making acyl amino acids using engineered polypeptides. In certain embodiments, an acyl amino acid produced using compositions and/or methods of the present invention comprises cocoyl glutamate.Type: ApplicationFiled: August 31, 2018Publication date: February 28, 2019Applicant: Modular Genetics, Inc.Inventors: Kevin A. Jarrell, Prashanth Vishwanath, Gabriel Oscar Reznik
-
Publication number: 20180340198Abstract: In certain embodiments, the present invention comprises compositions and methods useful in the generation of acyl amino acids. In certain embodiments, the present invention provides an engineered polypeptide comprising a peptide synthetase domain; in some such embodiments, the engineered polypeptide comprises only a single peptide synthetase domain. In some embodiments, the present invention provides an engineered peptide synthetase that is substantially free of a thioesterase domain, and/or a reductase domain. In certain embodiments, the present invention provides an acyl amino acid composition comprising a plurality of different forms of an acyl amino acid. In some such compositions, substantially all of the acyl amino acids within the composition contain the same amino acid moiety and differ with respect to acyl moiety. We also described populations where the fatty acid si for example 95% one length (C14, myristic).Type: ApplicationFiled: May 14, 2018Publication date: November 29, 2018Inventors: Kevin A. Jarrell, Gabriel O. Reznik, Prashanth Vishwanath, Michelle Pynn
-
Patent number: 10093935Abstract: Engineered polypeptides useful in synthesizing acyl amino acids are provided. Also provided are methods of making acyl amino acids using engineered polypeptides. In certain embodiments, an acyl amino acid produced using compositions and/or methods of the present invention comprises cocoyl glutamate.Type: GrantFiled: September 30, 2016Date of Patent: October 9, 2018Assignee: Modular Genetics, Inc.Inventors: Kevin A. Jarrell, Prashanth Vishwanath, Gabriel Oscar Reznik
-
Patent number: 9970036Abstract: Engineered polypeptides useful in synthesizing acyl amino acids are provided. Also provided are methods of making acyl amino acids using engineered polypeptides.Type: GrantFiled: March 14, 2014Date of Patent: May 15, 2018Assignee: MODULAR GENETICS, INC.Inventors: Kevin A. Jarrell, Gabriel O. Reznik, Prashanth Vishwanath, Michelle Pynn
-
Publication number: 20180057545Abstract: The disclosure provides amino acid sequence variants of Bacillus thuringiensis (Bt) toxins and methods of producing the same. Some aspects of this disclosure provide methods for generating Bt toxin variants by continuous directed evolution. Some aspects of this disclosure provide compositions and methods for pest control using the disclosed variant Bt toxins.Type: ApplicationFiled: July 22, 2016Publication date: March 1, 2018Inventors: David R. Liu, Ahmed Hussein Badran, Victor Guzov, Tom Malvar, Prashanth Vishwanath, Jeff Nageotte, Qing Huai, Melissa Kemp
-
Publication number: 20170029473Abstract: The disclosure provides amino acid sequence variants of Bacillus thuringiensis (Bt) toxins and methods of producing the same. Some aspects of this disclosure provide methods for generating Bt toxin variants by continuous directed evolution. Some aspects of this disclosure provide compositions and methods for pest control using the disclosed variant Bt toxins.Type: ApplicationFiled: July 22, 2016Publication date: February 2, 2017Inventors: David R. Liu, Ahmed Hussein Badran, Victor Guzov, Tom Malvar, Prashanth Vishwanath, Jeff Nageotte, Qing Huai, Melissa Kemp
-
Publication number: 20170016006Abstract: Engineered polypeptides useful in synthesizing acyl amino acids are provided. Also provided are methods of making acyl amino acids using engineered polypeptides. In certain embodiments, an acyl amino acid produced using compositions and/or methods of the present invention comprises cocoyl glutamate.Type: ApplicationFiled: September 30, 2016Publication date: January 19, 2017Inventors: Kevin A. JARRELL, Prashanth VISHWANATH, Gabriel Oscar REZNIK
-
Patent number: 9493800Abstract: Engineered polypeptides useful in synthesizing acyl amino acids are provided. Also provided are methods of making acyl amino acids using engineered polypeptides. In certain embodiments, an acyl amino acid produced using compositions and/or methods of the present invention comprises cocoyl glutamate.Type: GrantFiled: July 19, 2011Date of Patent: November 15, 2016Assignee: MODULAR GENETICS, INC.Inventors: Kevin A. Jarrell, Prashanth Vishwanath, Gabriel Reznik
-
Publication number: 20160076065Abstract: Engineered polypeptides useful in synthesizing acyl amino acids are provided. Also provided are methods of making acyl amino acids using engineered polypeptides.Type: ApplicationFiled: March 14, 2014Publication date: March 17, 2016Inventors: Kevin A. Jarrell, Gabriel O. Reznik, Prashanth Vishwanath, Michelle Pynn
-
Publication number: 20130071885Abstract: Engineered polypeptides useful in synthesizing acyl amino acids are provided. Also provided are methods of making acyl amino acids using engineered polypeptides. In certain embodiments, an acyl amino acid produced using compositions and/or methods of the present invention comprises cocoyl glutamate.Type: ApplicationFiled: July 19, 2011Publication date: March 21, 2013Inventors: Kevin A. Jarrell, Prashanth Vishwanath, Gabriel Reznik
-
Patent number: 7981685Abstract: Engineered polypeptides useful in synthesizing acyl amino acids are provided. Also provided are methods of making acyl amino acids using engineered polypeptides. In certain embodiments, an acyl amino acid produced using compositions and/or methods of the present invention comprises cocoyl glutamate.Type: GrantFiled: April 16, 2008Date of Patent: July 19, 2011Assignee: Modular Genetics, Inc.Inventors: Kevin A. Jarrell, Prashanth Vishwanath, Gabriel Reznik
-
Publication number: 20110030102Abstract: Engineered polypeptides useful in synthesizing acyl amino acids are provided. Also provided are methods of making acyl amino acids using engineered polypeptides. In certain embodiments, an acyl amino acid produced using compositions and/or methods of the present invention comprises cocoyl glutamate.Type: ApplicationFiled: April 16, 2008Publication date: February 3, 2011Inventors: Kevin A. Jarrell, Prashanth Vishwanath, Gabriel Reznik
-
Publication number: 20110030103Abstract: Novel lipopeptides, and engineered polypeptides useful in synthesizing lipopeptides are provided. Also provided are methods of making lipopeptides using engineered polypeptides, and methods of using lipopeptides, e.g., as insecticidal and/or antimicrobial agents.Type: ApplicationFiled: April 16, 2008Publication date: February 3, 2011Inventors: Gabriel Reznik, Kevin A. Jarrell, Prashanth Vishwanath