Patent number: 11306100
Abstract: The present invention provides a compound of general formulae I useful as GSK3? inhibitors and their anticancer potential and process for preparation of these spirooxindoles. wherein Z is hydrogen, halogen, hydroxy, alkoxy, cyano, nitro; Ring A is a five membered or six membered or seven membered optionally containing additional hetero atom in the ring X is optionally CH2 Ring B is triazole or cyclic amine alone or with one or more hetero atoms part of the ring and optionally substituted with one or more substituents Y is hydrogen, alkoxy, aryloxy, hydroxy, ester, amide, amino, alkyl or aryl, heteroaryl, wherein these substituents are optionally substituted with one or more halogen, hydroxy, alkoxy, alkyl, aryl, heteroaryl, aryloxy, nitro, cyano, ester, aldehyde, wherein these substituents are further substituted with one or more halogen, hydroxy, alkoxy, alkyl, aryl, heteroaryl, aryloxy, nitro, cyano, ester, aldehyde.
Type:
Grant
Filed:
March 9, 2018
Date of Patent:
April 19, 2022
Inventors:
Prathama S. Mainkar, Mohammad Abdul Sattar, Pitchakuntla Mallesham, Togapur Pavan Kumar, Divya Duscharla, Ummanni Ramesh, Srivari Chandrasekhar
Publication number: 20210284650
Abstract: The present invention provides a compound of general formulae I useful as GSK3? inhibitors and their anticancer potential and process for preparation of these spirooxindoles. wherein Z is hydrogen, halogen, hydroxy, alkoxy, cyano, nitro; Ring A is a five membered or six membered or seven membered optionally containing additional hetero atom in the ring X is optionally CH2 Ring B is triazole or cyclic amine alone or with one or more hetero atoms part of the ring and optionally substituted with one or more substituents Y is hydrogen, alkoxy, aryloxy, hydroxy, ester, amide, amino, alkyl or aryl, heteroaryl, wherein these substituents are optionally substituted with one or more halogen, hydroxy, alkoxy, alkyl, aryl, heteroaryl, aryloxy, nitro, cyano, ester, aldehyde, wherein these substituents are further substituted with one or more halogen, hydroxy, alkoxy, alkyl, aryl, heteroaryl, aryloxy, nitro, cyano, ester, aldehyde.
Type:
Application
Filed:
March 9, 2018
Publication date:
September 16, 2021
Inventors:
Prathama S. MAINKAR, Mohammad Abdul SATTAR, Pitchakuntla MALLESHAM, Togapur Pavan KUMAR, Divya DUSCHARLA, Ummanni RAMESH, Srivari CHANDRASEKHAR