Patents by Inventor Pratiksha Thakore

Pratiksha Thakore has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods and compositions for multiplexing single cell and single nuclei sequencing
    Patent number: 11332736
    Abstract: The present invention provides methods and tools for analyzing genetic interactions. The subject matter disclosed herein is generally directed to single cell genomics and proteomics. In one embodiment provided is a method of cell and nuclei hashing using sample barcodes. In another embodiment are method of performing genomewide CRISPR perturbation screens.
    Type: Grant
    Filed: December 7, 2018
    Date of Patent: May 17, 2022
    Assignees: The Broad Institute, Inc., Massachusetts Institute of Technology
    Inventors: Aviv Regev, Orit Rozenblatt-Rosen, Jellert Gaublomme, Bo Li, Kathryn Geiger-Schuller, Pratiksha Thakore
  • COMPOSITIONS AND METHODS FOR MODULATING CANCER IMMUNE FITNESS
    Publication number: 20220002416
    Abstract: Methods of targeting CD58 signaling to enhance antitumor immunity and overcome resistance to checkpoint blockade therapy. Gene signatures associated with immune fitness were identified. Markers and therapeutic targets for such immunotherapy resistance.
    Type: Application
    Filed: June 28, 2021
    Publication date: January 6, 2022
    Inventors: Benjamin IZAR, Johannes C. MELMS, Pratiksha Thakore, Katie GEIGER-SCHULLER, Aviv REGEV, Chris FRANGIEH
  • METHODS AND COMPOSITIONS FOR MASSIVELY PARALLEL VARIANT AND SMALL MOLECULE PHENOTYPING
    Publication number: 20200283843
    Abstract: The present invention provides methods and tools for analyzing genetic interactions. The subject matter is generally directed to single-cell genomics and proteomics, including methods of performing genome-wide CRISPR perturbation screens and determining gene expression phenotypes.
    Type: Application
    Filed: March 4, 2020
    Publication date: September 10, 2020
    Inventors: Aviv Regev, Pratiksha Thakore, John Doench, JT Neal, Jesse Boehm, Oana Ursu