Patents by Inventor Pratip Bhattacharya

Pratip Bhattacharya has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10124076
    Abstract: Compositions and methods useful in connection with magnetic resonance imaging are provided. Metabolites hyperpolarized by dynanic nuclear polarization are used as reporter molecules in nuclear magnetic resonance (“NMR”) spectroscopy to study metabolic pathways and diagnose disease states. The reporter molecules include hyperpolarized glutamine and hyperpolarized acetate. The invention includes the reporter molecules, compositions including the reporter molecules in pharmaceutically acceptable carriers, methods for studying metabolic pathways that include introducing one or more of the reporter molecules to a mammalian subject and imaging a target substance using NMR spectroscopy, and kits useful in studying metabolic pathways that incorporate one or more of the reporter molecules and instructions for their use.
    Type: Grant
    Filed: February 27, 2013
    Date of Patent: November 13, 2018
    Assignee: HUNTINGTON MEDICAL RESEARCH INSTITUTES
    Inventors: Brian D. Ross, Pratip Bhattacharya
  • Patent number: 9207296
    Abstract: The present subject matter relates to methods and apparatus for using hyperpolarization to improve imaging. Am exemplary embodiment, a PASADENA polarizer, is capable of delivering 2.5-5 ml of highly hyperpolarized biological 13C and 15N imaging reagents in less than one minute, and capable of repeated delivery every 5-8 minutes. Exemplary quality control sequences are also provided to create versatile methods, systems, and apparatuses for a variety of biomolecules, capable of undergoing reaction with parahydrogen necessary for effective PASADENA. The subject matter simplifies the technology for routine liquid state generation of hyperpolarized molecules for 13C and 15N subsecond imaging and spectroscopy in vivo and further advance the clinical application of this technology. Methods and systems for providing magnetic shielding are also provided.
    Type: Grant
    Filed: May 20, 2014
    Date of Patent: December 8, 2015
    Assignee: Huntington Medical Research Institutes
    Inventors: Pratip Bhattacharya, Brian D. Ross
  • Patent number: 9034928
    Abstract: The present embodiments disclose the preparation of hyperpolarized 13C dialkyl succinate compounds and hyperpolarized 13C dialkyl fumarate compounds and their use in real time, in vivo metabolic imaging of the TCA cycle.
    Type: Grant
    Filed: January 17, 2014
    Date of Patent: May 19, 2015
    Assignee: IMAGNX, Inc.
    Inventors: Niki Zacharias Millward, Pratip Bhattacharya
  • Publication number: 20150022204
    Abstract: The present subject matter relates to methods and apparatus for using hyperpolarization to improve imaging. Am exemplary embodiment, a PASADENA polarizer, is capable of delivering 2.5-5 ml of highly hyperpolarized biological 13C and 15N imaging reagents in less than one minute, and capable of repeated delivery every 5-8 minutes. Exemplary quality control sequences are also provided to create versatile methods, systems, and apparatuses for a variety of biomolecules, capable of undergoing reaction with parahydrogen necessary for effective PASADENA. The subject matter simplifies the technology for routine liquid state generation of hyperpolarized molecules for 13C and 15N subsecond imaging and spectroscopy in vivo and further advance the clinical application of this technology. Methods and systems for providing magnetic shielding are also provided.
    Type: Application
    Filed: May 20, 2014
    Publication date: January 22, 2015
    Applicant: Huntington Medical Research Institutes
    Inventors: Pratip BHATTACHARYA, Brian D. ROSS
  • Patent number: 8766633
    Abstract: The present subject matter relates to methods and apparatus for using hyperpolarization to improve imaging. Am exemplary embodiment, a PASADENA polarizer, is capable of delivering 2.5-5 ml of highly hyperpolarized biological 13C and 15N imaging reagents in less than one minute, and capable of repeated delivery every 5-8 minutes. Exemplary quality control sequences are also provided to create versatile methods, systems, and apparatuses for a variety of biomolecules, capable of undergoing reaction with parahydrogen necessary for effective PASADENA. The subject matter simplifies the technology for routine liquid state generation of hyperpolarized molecules for 13C and 15N subsecond imaging and spectroscopy in vivo and further advance the clinical application of this technology. Methods and systems for providing magnetic shielding are also provided.
    Type: Grant
    Filed: October 14, 2010
    Date of Patent: July 1, 2014
    Assignee: Huntington Medical Research Institutes
    Inventors: Pratip Bhattacharya, Brian D. Ross
  • Publication number: 20140134108
    Abstract: The present embodiments disclose the preparation of hyperpolarized 13C dialkyl succinate compounds and hyperpolarized 13C dialkyl fumarate compounds and their use in real time, in vivo metabolic imaging of the TCA cycle.
    Type: Application
    Filed: January 17, 2014
    Publication date: May 15, 2014
    Inventors: Niki Zacharias Millward, Pratip Bhattacharya
  • Patent number: 8664279
    Abstract: The present embodiments disclose the preparation of hyperpolarized 13C dialkyl succinate compounds and hyperpolarized 13C dialkyl fumarate compounds and their use in real time, in vivo metabolic imaging of the TCA cycle.
    Type: Grant
    Filed: July 1, 2012
    Date of Patent: March 4, 2014
    Inventors: Niki Zacharias Millward, Pratip Bhattacharya
  • Publication number: 20130006099
    Abstract: The present embodiments disclose the preparation of hyperpolarized 13C dialkyl succinate compounds and hyperpolarized 13C dialkyl fumarate compounds and their use in real time, in vivo metabolic imaging of the TCA cycle.
    Type: Application
    Filed: July 1, 2012
    Publication date: January 3, 2013
    Inventors: Niki Zacharias Millward, Pratip Bhattacharya
  • Publication number: 20110095759
    Abstract: The present subject matter relates to methods and apparatus for using hyperpolarization to improve imaging. Am exemplary embodiment, a PASADENA polarizer, is capable of delivering 2.5-5 ml of highly hyperpolarized biological 13C and 15N imaging reagents in less than one minute, and capable of repeated delivery every 5-8 minutes. Exemplary quality control sequences are also provided to create versatile methods, systems, and apparatuses for a variety of biomolecules, capable of undergoing reaction with parahydrogen necessary for effective PASADENA. The subject matter simplifies the technology for routine liquid state generation of hyperpolarized molecules for 13C and 15N subsecond imaging and spectroscopy in vivo and further advance the clinical application of this technology. Methods and systems for providing magnetic shielding are also provided.
    Type: Application
    Filed: October 14, 2010
    Publication date: April 28, 2011
    Applicant: HUNTINGTON MEDICAL RESEARCH INSTITUTES
    Inventors: Pratip BHATTACHARYA, Brian D. ROSS
  • Publication number: 20100233089
    Abstract: A method for imaging genetic material such as DNA, RNA and genes by magnetic resonance imaging incorporating hyperpolarization techniques, such as PASADENA or DNP may be used in various app metabolomics, medical diagnosis and genetic research.
    Type: Application
    Filed: October 6, 2008
    Publication date: September 16, 2010
    Applicant: HUNTINGTON MEDICAL RESEARCH INSTITUTES
    Inventors: Brian D. Ross, Pratip Bhattacharya
  • Publication number: 20100092391
    Abstract: Compositions and methods useful in connection with magnetic resonance imaging are provided. Metabolites hyperpolarized by dynamic nuclear polarization are used as reporter molecules in nuclear magnetic resonance (“NMR”) spectroscopy to study metabolic pathways and diagnose disease states. The reporter molecules include hyperpolarized glutamine and hyperpolarized acetate. The invention includes the reporter molecules, compositions including the reporter molecules in pharmaceutically acceptable carriers, methods for studying metabolic pathways that include introducing one or more of the reporter molecules to a mammalian subject and imaging a target substance using NMR spectroscopy, and kits useful in studying metabolic pathways that incorporate one or more of the reporter molecules and instructions for their use.
    Type: Application
    Filed: January 11, 2008
    Publication date: April 15, 2010
    Applicant: HUNTINGTON MEDICAL RESEARCH INSTITUTES
    Inventors: Brian D. Ross, Pratip Bhattacharya
  • Publication number: 20090264732
    Abstract: The present invention relates to compositions and methods useful in connection with magnetic resonance imaging. In various embodiments, the invention employs the PASADENA polarization technique to prepare contrast agents that target complementary molecules in the body and/or that are processed through predetermined, natural metabolic pathways. The invention includes methods of using the contrast agents and kits including the same. In one embodiment, a diagnostic and prognostic method relating to Alzheimer's disease is described. Further embodiments relate to medical devices including the contrast agents.
    Type: Application
    Filed: October 11, 2006
    Publication date: October 22, 2009
    Applicant: HUNTINGTON MEDICAL RESEARCH INSTITUTES
    Inventors: Brian D. Ross, Pratip Bhattacharya