Patents by Inventor Pratip Bhattacharya
Pratip Bhattacharya has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10124076Abstract: Compositions and methods useful in connection with magnetic resonance imaging are provided. Metabolites hyperpolarized by dynanic nuclear polarization are used as reporter molecules in nuclear magnetic resonance (“NMR”) spectroscopy to study metabolic pathways and diagnose disease states. The reporter molecules include hyperpolarized glutamine and hyperpolarized acetate. The invention includes the reporter molecules, compositions including the reporter molecules in pharmaceutically acceptable carriers, methods for studying metabolic pathways that include introducing one or more of the reporter molecules to a mammalian subject and imaging a target substance using NMR spectroscopy, and kits useful in studying metabolic pathways that incorporate one or more of the reporter molecules and instructions for their use.Type: GrantFiled: February 27, 2013Date of Patent: November 13, 2018Assignee: HUNTINGTON MEDICAL RESEARCH INSTITUTESInventors: Brian D. Ross, Pratip Bhattacharya
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Patent number: 9207296Abstract: The present subject matter relates to methods and apparatus for using hyperpolarization to improve imaging. Am exemplary embodiment, a PASADENA polarizer, is capable of delivering 2.5-5 ml of highly hyperpolarized biological 13C and 15N imaging reagents in less than one minute, and capable of repeated delivery every 5-8 minutes. Exemplary quality control sequences are also provided to create versatile methods, systems, and apparatuses for a variety of biomolecules, capable of undergoing reaction with parahydrogen necessary for effective PASADENA. The subject matter simplifies the technology for routine liquid state generation of hyperpolarized molecules for 13C and 15N subsecond imaging and spectroscopy in vivo and further advance the clinical application of this technology. Methods and systems for providing magnetic shielding are also provided.Type: GrantFiled: May 20, 2014Date of Patent: December 8, 2015Assignee: Huntington Medical Research InstitutesInventors: Pratip Bhattacharya, Brian D. Ross
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Patent number: 9034928Abstract: The present embodiments disclose the preparation of hyperpolarized 13C dialkyl succinate compounds and hyperpolarized 13C dialkyl fumarate compounds and their use in real time, in vivo metabolic imaging of the TCA cycle.Type: GrantFiled: January 17, 2014Date of Patent: May 19, 2015Assignee: IMAGNX, Inc.Inventors: Niki Zacharias Millward, Pratip Bhattacharya
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Publication number: 20150022204Abstract: The present subject matter relates to methods and apparatus for using hyperpolarization to improve imaging. Am exemplary embodiment, a PASADENA polarizer, is capable of delivering 2.5-5 ml of highly hyperpolarized biological 13C and 15N imaging reagents in less than one minute, and capable of repeated delivery every 5-8 minutes. Exemplary quality control sequences are also provided to create versatile methods, systems, and apparatuses for a variety of biomolecules, capable of undergoing reaction with parahydrogen necessary for effective PASADENA. The subject matter simplifies the technology for routine liquid state generation of hyperpolarized molecules for 13C and 15N subsecond imaging and spectroscopy in vivo and further advance the clinical application of this technology. Methods and systems for providing magnetic shielding are also provided.Type: ApplicationFiled: May 20, 2014Publication date: January 22, 2015Applicant: Huntington Medical Research InstitutesInventors: Pratip BHATTACHARYA, Brian D. ROSS
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Patent number: 8766633Abstract: The present subject matter relates to methods and apparatus for using hyperpolarization to improve imaging. Am exemplary embodiment, a PASADENA polarizer, is capable of delivering 2.5-5 ml of highly hyperpolarized biological 13C and 15N imaging reagents in less than one minute, and capable of repeated delivery every 5-8 minutes. Exemplary quality control sequences are also provided to create versatile methods, systems, and apparatuses for a variety of biomolecules, capable of undergoing reaction with parahydrogen necessary for effective PASADENA. The subject matter simplifies the technology for routine liquid state generation of hyperpolarized molecules for 13C and 15N subsecond imaging and spectroscopy in vivo and further advance the clinical application of this technology. Methods and systems for providing magnetic shielding are also provided.Type: GrantFiled: October 14, 2010Date of Patent: July 1, 2014Assignee: Huntington Medical Research InstitutesInventors: Pratip Bhattacharya, Brian D. Ross
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Publication number: 20140134108Abstract: The present embodiments disclose the preparation of hyperpolarized 13C dialkyl succinate compounds and hyperpolarized 13C dialkyl fumarate compounds and their use in real time, in vivo metabolic imaging of the TCA cycle.Type: ApplicationFiled: January 17, 2014Publication date: May 15, 2014Inventors: Niki Zacharias Millward, Pratip Bhattacharya
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Patent number: 8664279Abstract: The present embodiments disclose the preparation of hyperpolarized 13C dialkyl succinate compounds and hyperpolarized 13C dialkyl fumarate compounds and their use in real time, in vivo metabolic imaging of the TCA cycle.Type: GrantFiled: July 1, 2012Date of Patent: March 4, 2014Inventors: Niki Zacharias Millward, Pratip Bhattacharya
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Publication number: 20130006099Abstract: The present embodiments disclose the preparation of hyperpolarized 13C dialkyl succinate compounds and hyperpolarized 13C dialkyl fumarate compounds and their use in real time, in vivo metabolic imaging of the TCA cycle.Type: ApplicationFiled: July 1, 2012Publication date: January 3, 2013Inventors: Niki Zacharias Millward, Pratip Bhattacharya
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Publication number: 20110095759Abstract: The present subject matter relates to methods and apparatus for using hyperpolarization to improve imaging. Am exemplary embodiment, a PASADENA polarizer, is capable of delivering 2.5-5 ml of highly hyperpolarized biological 13C and 15N imaging reagents in less than one minute, and capable of repeated delivery every 5-8 minutes. Exemplary quality control sequences are also provided to create versatile methods, systems, and apparatuses for a variety of biomolecules, capable of undergoing reaction with parahydrogen necessary for effective PASADENA. The subject matter simplifies the technology for routine liquid state generation of hyperpolarized molecules for 13C and 15N subsecond imaging and spectroscopy in vivo and further advance the clinical application of this technology. Methods and systems for providing magnetic shielding are also provided.Type: ApplicationFiled: October 14, 2010Publication date: April 28, 2011Applicant: HUNTINGTON MEDICAL RESEARCH INSTITUTESInventors: Pratip BHATTACHARYA, Brian D. ROSS
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Publication number: 20100233089Abstract: A method for imaging genetic material such as DNA, RNA and genes by magnetic resonance imaging incorporating hyperpolarization techniques, such as PASADENA or DNP may be used in various app metabolomics, medical diagnosis and genetic research.Type: ApplicationFiled: October 6, 2008Publication date: September 16, 2010Applicant: HUNTINGTON MEDICAL RESEARCH INSTITUTESInventors: Brian D. Ross, Pratip Bhattacharya
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Publication number: 20100092391Abstract: Compositions and methods useful in connection with magnetic resonance imaging are provided. Metabolites hyperpolarized by dynamic nuclear polarization are used as reporter molecules in nuclear magnetic resonance (“NMR”) spectroscopy to study metabolic pathways and diagnose disease states. The reporter molecules include hyperpolarized glutamine and hyperpolarized acetate. The invention includes the reporter molecules, compositions including the reporter molecules in pharmaceutically acceptable carriers, methods for studying metabolic pathways that include introducing one or more of the reporter molecules to a mammalian subject and imaging a target substance using NMR spectroscopy, and kits useful in studying metabolic pathways that incorporate one or more of the reporter molecules and instructions for their use.Type: ApplicationFiled: January 11, 2008Publication date: April 15, 2010Applicant: HUNTINGTON MEDICAL RESEARCH INSTITUTESInventors: Brian D. Ross, Pratip Bhattacharya
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Publication number: 20090264732Abstract: The present invention relates to compositions and methods useful in connection with magnetic resonance imaging. In various embodiments, the invention employs the PASADENA polarization technique to prepare contrast agents that target complementary molecules in the body and/or that are processed through predetermined, natural metabolic pathways. The invention includes methods of using the contrast agents and kits including the same. In one embodiment, a diagnostic and prognostic method relating to Alzheimer's disease is described. Further embodiments relate to medical devices including the contrast agents.Type: ApplicationFiled: October 11, 2006Publication date: October 22, 2009Applicant: HUNTINGTON MEDICAL RESEARCH INSTITUTESInventors: Brian D. Ross, Pratip Bhattacharya