Abstract: The present disclosure relates to bifunctional chemical conjugation molecules, which find utility as modifiers of target substrates. The present disclosure includes multifunctional compounds comprising an enzyme binding moiety, a chemical linker moiety, and a target binding moiety, which may further include an electrophilic reactive group. Molecules according to the present invention find use making substrate modifications such as post-translational modifications to proteins that are not the natural substrate of the enzyme. Diseases or disorders may be treated or prevented with molecules of the present disclosure.

Abstract: A system generates vector representations of entries of traffic logs generated by a firewall. A first model learns contexts of values recorded in the logs during training, and the system extracts vector representations of the values from the trained model. For each log entry, vectors created for the corresponding values are combined to create a vector representing the entry. Cluster analysis of the vector representations can be performed to determine clusters of similar traffic and outliers indicative of potentially anomalous traffic. The system also generates a formal model representing firewall behavior which comprises formulas generated from the firewall rules. Proposed traffic scenarios not recorded in the logs can be evaluated based on the formulas to determine actions which the firewall would take in the scenarios. The combination of models which implement machine learning and formal techniques facilitates evaluation of both observed and hypothetical network traffic based on the firewall rules.

Abstract: The invention relates to a process of preparation of enantiomerically pure Linezolid Form-I comprising converting a substantially enantiomerically pure linezolid hydroxide compound of formula II to Linezolid Form I compound of formula I.

Abstract: Formal verification of connectivity of a circuit, for example, a circuit representing a system on chip I/O ring is performed with low power considerations. The formal verification determines whether the connectivity of a circuit remains valid when low power design specification is introduced. The system receives assertions representing connectivity of the circuit. The system receives low power design specification for a circuit that describes power states of power domains of the circuit. The system generates combinational constraints representing valid power states of power domains of the circuit. The system performs formal verification based on the assertions representing the connectivity of the circuit and the combinational constraints representing the power states of power domains of the circuit. The result of the formal verification is used to determine whether the connectivity of the circuit is valid in view of the low power design specification.

Abstract: Formal verification of a circuit design is performed with low power considerations. The formal verification process receives a circuit design and a low power design specification. The low power design specification identifies power domains for the circuit. The system models undefined signal reaching nodes of the circuit from components of power domains that are switched off. The system selects a subset of nodes at which undefined signal reaches, thereby excluding certain nodes from the analysis. The selection of a small subset of nodes for analyzing undefined signals increases the efficiency of the formal verification process. The system annotates the circuit design to allow undefined signals to be introduced at the selected nodes. The system performs formal verification of the annotated circuit design.

Abstract: Formal verification of connectivity of a circuit, for example, a circuit representing a system on chip I/O ring is performed with low power considerations. The formal verification determines whether the connectivity of a circuit remains valid when low power design specification is introduced. The system receives assertions representing connectivity of the circuit. The system receives low power design specification for a circuit that describes power states of power domains of the circuit. The system generates combinational constraints representing valid power states of power domains of the circuit. The system performs formal verification based on the assertions representing the connectivity of the circuit and the combinational constraints representing the power states of power domains of the circuit. The result of the formal verification is used to determine whether the connectivity of the circuit is valid in view of the low power design specification.

Abstract: The invention relates to a substantially pure linezolid hydroxide having R-isomer content more than about 99.9% relative to its S-isomer. Further aspect of invention provides the ambient moisture condition, which is critical for enantiomeric pure linezolid hydroxide. The obtained substantially enantiomerically pure linezolid hydroxide compound of formula-II can be subsequently converted into the linezolid compound of formula-I, having S-isomer content more than 99.9% relative to R-isomer. Further the invention provides an improved process for preparation of enantiomeric pure linezolid Form-I, wherein linezolid Form-I having the purity more than 99.9% relative to any other known polymorphic form of linezolid. The obtained enantiomeric pure linezolid Form-I can be subsequently converted into the other known polymorphic forms linezolid. The invention also provides stable and substantially solvent-free crystal of Form-I of linezolid.

Abstract: This invention is a high-level language to specify electronic system design patterns for functional verification. This invention includes automatic translation of the high-level language specification into assertion code from these patterns and temporal properties for design verification. This eliminates the need to code extra RTL to handle features such as pipelines and bus priorities. Such common features are specified only in high-level patterns and temporal properties to be verified. This is advantageous because less verification code to be written, automated synthesis of assertions enforces monitor-style of writing assertions rather than generator-style, and the high-level code can be seamlessly migrated to another verification tool by producing another code generator for the new assertion language.

Abstract: This invention is a high-level language to specify electronic system design patterns for functional verification. This invention includes automatic translation of the high-level language specification into assertion code from these patterns and temporal properties for design verification. This eliminates the need to code extra RTL to handle features such as pipelines and bus priorities. Such common features are specified only in high-level patterns and temporal properties to be verified. This is advantageous because less verification code to be written, automated synthesis of assertions enforces monitor-style of writing assertions rather than generator-style, and the high-level code can be seamlessly migrated to another verification tool by producing another code generator for the new assertion language.