Abstract: Synchronously negotiating an object's creation time including identifying, by a first storage system among the two or more storage systems, a request to store a second updated version of the object; detecting, by the first storage system, a communications disruption among the two or more storage systems; and establishing, in dependence upon a local clock of the first storage system and a latest observed creation time associated with the object, a creation time for the second updated version of the object.

Abstract: Disclosed is nicotine containing solid oral transmucosal dosage forms containing a therapeutically effective amount of nicotine polacrilex, citric acid monohydrate, sucrose and liquid glucose. The dosage form is preferably in the form of lozenge.

Abstract: Disclosed is nicotine containing solid oral transmucosal dosage forms containing a therapeutically effective amount of nicotine polacrilex, citric acid monohydrate, sucrose and liquid glucose. The dosage form is preferably in the form of lozenge.

Abstract: A fan inlet flow distributor comprises a skewed elliptical cone or equivalent body installed between an inlet opening of a centrifugal blower and an adjacent wall that faces the inlet. When all of the incoming airflow approaches the blower from the same general direction parallel to the wall and then makes a right turn to enter the blower's inlet, the unique shape of the flow distributor promotes a circumferentially uniform flow pattern as the air enters the fan's inlet. In some embodiments, the flow distributor comprises a skewed elliptical hyperboloid near its base and a skewed elliptical paraboloid near its vertex. The flow distributor is preferably attached to the wall and spaced apart from the fan's housing to ensure an unobstructed flow path between the distributor and the fan housing.

Abstract: The present invention describes a novel controlled release multilayer composition that is capable of delivering a first active agent from one layer immediately followed by continuous controlled delivery of second active agent from matrix forming layer while the dosage form floats and is retained in the fluid of the environment. The floating bilayer system comprises of immediate release layer containing one active agent and a disintegrating agent whereas second floating matrix forming layer comprises a gas generating component, a gelling agent, and a second active agent. The present invention relates more particularly to a controlled release fluoroquinolone compositions, which maintain a therapeutically effective blood concentration of fluoroquinolone for duration with once a day administration.

Abstract: A centrifugal blower with forward curved fan blades includes an inlet shroud whose shape is specifically designed for creating a smooth incoming airflow pattern that leads into the inner leading edges of the fan blades. The inlet shroud has first and second curved surfaces, wherein the centers of curvature of the two surfaces lie in the same plane, and the center of curvature as well as the radius of curvature of one curved surface is greater than that of the other. At least one center of curvature lies beyond the outer diameter of the impeller, and at least one center of curvature lies beyond the impeller's inner diameter, wherein the impeller's inner diameter is defined by the inner leading edges of the fan blades. Performance benefits are achieved when a forward curved blower with such an inlet shroud operates with a flow coefficient of between 9 and 52.

Abstract: The present invention describes a novel controlled release multilayer composition that is capable of delivering a first active agent from one layer immediately followed by continuous controlled delivery of second active agent from matrix forming layer while the dosage form floats and is retained in the fluid of the environment. The floating bilayer system comprises of immediate release layer containing one active agent and a disintegrating agent whereas second floating matrix forming layer comprises a gas generating component, a gelling agent, and a second active agent. The present invention relates more particularly to a controlled release fluoroquinolone compositions, which maintain a therapeutically effective blood concentration of fluoroquinolone for duration with once a day administration.

Abstract: The present invention provides a novel floating osmotic device that is capable of delivering a first active agent in an outer coat immediately followed by continuous controlled delivery of second active agent from the osmotic core while the dosage form floats in the fluid of the environment. The floating osmotic device has of a compressed core containing active agent, a semipermeable membrane surrounding the core that is permeable to surrounding fluid and impermeable to the active agent, and an outer coating of a gas generating ingredient, a gelling agent, and a second active agent. Particular embodiments of the invention provide floating osmotic devices in which all two active agents are similar or dissimilar.

Abstract: Pharmaceutical dental gel preparation comprising of metronidazole benzoate, chlorhexidine gluconate, and local anesthetic as the active ingredient; glycol as the solvent medium; a carboxyvinyl polymer, cross-linked polymer of acrylic acid copolymerized with polyalkylsucrose as a gelling agent.