Patents by Inventor Preethi Soysa

Preethi Soysa has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method to isolate inoscavin a from and medicinal preparation thereof to treat rhabdomyosarcoma cancer conditions
    Patent number: 10501472
    Abstract: The invention relates to a novel method to isolate a natural product, a flavonoid namely inoscavin A from a Sri Lankan mushroom, medicinal preparation thereof to treat rhabdomyosarcoma cancer condition. This compound was isolated from the terrestrial basidiomycete Fulviformes fastuosus for the first time. The isolation method of the inoscavin A comprises the following steps of: (1) carrying out sonication extraction of pulverized specimen by methanol; (2) partitioning in to hexane, dichloromethane and ethyl acetate respectively by liquid-liquid extraction 3) fractionation using normal phase silica gel column chromatography 4) purification using preparative high performance liquid chromatography (HPLC) to obtain flavonoid compound inoscavin A in substantially purified form (?98%). In vitro cytotoxicity experiments demonstrated that the composition comprising inoscavin A strongly induced the apoptosis of human rhabdomyosarcoma (RD) cells compared to the cytotoxicity produced on normal epithelial cells (CC-1).
    Type: Grant
    Filed: November 23, 2015
    Date of Patent: December 10, 2019
    Inventors: Dilusha Fernando, Ravi Wijesundera, Preethi Soysa, Dilip de Silva, Chandrika Nanayakkara, Achyut Adhikari
  • A Novel Method To Isolate Inoscavin A From Fulviformes Fastuosus And Medicinal Preparation Thereof To Treat Rhabdomyosarcoma Cancer Conditions
    Publication number: 20180370985
    Abstract: The invention relates to a novel method to isolate a natural product, a flavonoid namely inoscavin A from a Sri Lankan mushroom, medicinal preparation thereof to treat rhabdomyosarcoma cancer condition. This compound was isolated from the terrestrial basidiomycete Fulviformes fastuosus for the first time. The isolation method of the inoscavin A comprises the following steps of: (1) carrying out sonication extraction of pulverized specimen by methanol; (2) partitioning in to hexane, dichloromethane and ethyl acetate respectively by liquid-liquid extraction 3) fractionation using normal phase silica gel column chromatography 4) purification using preparative high performance liquid chromatography (HPLC) to obtain flavonoid compound inoscavin A in substantially purified form (?98%). In vitro cytotoxicity experiments demonstrated that the composition comprising inoscavin A strongly induced the apoptosis of human rhabdomyosarcoma (RD) cells compared to the cytotoxicity produced on normal epithelial cells (CC-1).
    Type: Application
    Filed: November 23, 2015
    Publication date: December 27, 2018
    Applicants: University of Colombo, National Research Council
    Inventors: Dilusha Fernando, Ravi Wijesundera, Preethi Soysa, Dilip de Silva, Chandrika Nanayakkara, Achyut Adhikari