Abstract: The invention provides a cDNA which encodes a G protein-coupled receptor differentially expressed in squamous cell carcinoma. It also provides for the use of the cDNA, fragments, complements, and variants thereof and of the encoded protein, portions thereof and antibodies thereto for diagnosis and treatment of cancer. The invention additionally provides expression vectors and host cells for the production of the protein and a transgenic model system.

Abstract: The invention provides cDNAs which encodes a signal peptide-containing proteins. It also provides for the use of a cDNA, protein, and antibody in the diagnosis, prognosis, treatment and evaluation of therapies for cancer. The invention further provides vectors and host cells for the production of the protein and transgenic model systems.

Abstract: The invention provides a cDNA which encodes a TNFR2PV. It also provides for the use of the cDNA, fragments, complements, and variants thereof and of the encoded protein, portions thereof and antibodies thereto for diagnosis and treatment of cancer and immune disorders, particularly cancer of the prostate, ovary, breast, and brain, or an inflammatory disorder, including rheumatoid arthritis, asthma, and ulcerative colitis. The invention additionally provides expression vectors and host cells for the production of the protein and a transgenic model system.

Abstract: The invention provides a cDNA which encodes a transmembrane protein differentially expressed in prostate and lung cancer. It also provides for the use of the cDNA, fragments, complements, and variants thereof and of the encoded protein, portions thereof and antibodies thereto for diagnosis and treatment of cancer, in particular, prostate or lung cancers. The invention additionally provides expression vectors and host cells for the production of the protein and a transgenic model system.

Abstract: The invention provides human ubiquitin-conjugating enzymes, cDNAs which encode the enzymes, and antibodies which specifically bind the enzymes. The invention also provides expression vectors, host cells, and antagonists and methods for diagnosing, treating or evaluating the treatment of disorders associated with differential expression of human ubiquitin-conjugating enzymes.

Abstract: The invention provides human cytochrome P450 variants (CYTPV) and polynucleotides which identify and encode CYTPV. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosing, treating, or preventing disorders associated with aberrant expression of CYTPV.

Abstract: The invention provides a human synaptojanin isoform (NSYN-1) and polynucleotides which identify and encode NSYN-1. The invention also provides expression vectors, host cells, agonists, antibodies and antagonists. The invention also provides methods for treating disorders associated with expression of NSYN-1.

Abstract: The present invention provides a human prostate-associated protease (HUPAP), polynucleotides which encode HUPAP and antibodies which specifically bind HUPAP. The invention also provides expression vectors, host cells, agonists, antagonists, and antisense molecules. The invention also provides methods for producing and using HUPAP and for treating disorders associated with expression of HUPAP.

Abstract: The invention provides a cDNA which encodes tapasin-like protein. It also provides for the use of the cDNA, protein, and antibody in the diagnosis, prognosis, treatment and evaluation of therapies for cancer. The invention further provides vectors and host cells for the production of the protein and transgenic model systems.

Abstract: The invention provides human GPCR proteins and their encoding cDNAs. It also provides for the use of the cDNAs, proteins, and antibodies in the diagnosis, prognosis, treatment and evaluation of therapies for neoplastic disorders and immune response. The invention further provides vectors and host cells for the production of the protein and transgenic model systems.

Abstract: The invention provides an isolated cDNA which encodes a cancer marker protein. It also provides for the use of the cDNA, fragments, complements, and variants thereof and of the encoded protein, portions thereof and antibodies thereto for diagnosis, prognosis, treatment and evaluation of therapies for cancer, particularly lymphoma and cancers of the bladder, colon, kidney, ovary, and testis. The invention further provides vectors and host cells for the production of the protein and transgenic model systems.