Abstract: A prosthetic heart valve may include a balloon-expandable frame formed of a plastically-expandable material, and a self-expanding frame formed of a self-expanding material, the self-expanding frame including a plurality of commissure attachment features. The valve may include a plurality of prosthetic leaflets, wherein pairs of adjacent prosthetic leaflets form commissures, each of the commissures being coupled to a corresponding one of the plurality of commissure attachment features. The balloon-expandable frame may be coupled to the self-expanding frame to form a hybrid frame, the hybrid frame including an inflow end and an outflow end, the balloon-expandable frame being positioned at the inflow end of the hybrid frame, and the self-expanding frame being positioned at the outflow end of the hybrid frame.

Abstract: A method of manufacturing a prosthetic heart valve includes coupling a plurality of prosthetic leaflets to each other, and coupling the plurality of prosthetic leaflets to a cuff, to form a valve assembly. The valve assembly may be coupled to a stent to form the prosthetic heart valve. The valve assembly may be formed prior to the plurality of prosthetic leaflets being coupled to the stent and prior to the cuff being coupled to the stent.

Abstract: A system for heart valve replacement includes a collapsible and expandable replacement heart valve and a packaging assembly for storing the replacement heart valve. The packaging assembly includes a funnel extending from a first end to a second end. The funnel has a first interior diameter at the first end and a second interior diameter, the second interior diameter smaller than the first interior diameter. The funnel defines an internal lumen extending between the first and second ends. The funnel defines a plurality of longitudinal slots extending along an interior surface of the funnel between the first and second ends.

Abstract: A system for heart valve replacement includes a collapsible and expandable replacement heart valve and a packaging assembly for storing the replacement heart valve. The packaging assembly includes a funnel extending from a first end to a second end. The funnel has a first interior diameter at the first end and a second interior diameter, the second interior diameter smaller than the first interior diameter. The funnel defines an internal lumen extending between the first and second ends. The funnel defines a plurality of longitudinal slots extending along an interior surface of the funnel between the first and second ends.

Abstract: A system for heart valve replacement includes a collapsible and expandable replacement heart valve and a packaging assembly for storing the replacement heart valve. The packaging assembly includes a funnel extending from a first end to a second end. The funnel has a first interior diameter at the first end and a second interior diameter, the second interior diameter smaller than the first interior diameter. The funnel defines an internal lumen extending between the first and second ends. The funnel defines a plurality of longitudinal slots extending along an interior surface of the funnel between the first and second ends.

Abstract: In some embodiments, a prosthetic heart valve system includes a stent having a plurality of commissure attachment features, a cuff coupled to the stent, and a plurality of leaflets, the cuff and the plurality of leaflets forming a valve assembly, each of the plurality leaflets having two leaflet attachment regions, the leaflet attachment regions being folded adjacent the plurality of commissure attachment features.

Abstract: The present disclosure describes devices, systems, and methods for intravascularly delivering an intravascular device to a targeted cardiac valve. In one aspect, a medical device includes a body and a plurality of positional markers positioned on the body, the plurality of positional markers being defined in part by at least one cutout and having at least one parameter selected such that the plurality of positional markers vibrates, in response to an ultrasound signal, at a resonant frequency.

Abstract: A method of manufacturing a prosthetic heart valve includes coupling a plurality of prosthetic leaflets to each other, and coupling the plurality of prosthetic leaflets to a cuff, to form a valve assembly. The valve assembly may be coupled to a stent to form the prosthetic heart valve. The valve assembly may be formed prior to the plurality of prosthetic leaflets being coupled to the stent and prior to the cuff being coupled to the stent.

Abstract: A roller cutter for cutting a material includes a rotatable roller, a rotatable blade, and a rotation transmission mechanism. The roller includes an outer rim configured to engage the material at a roller engagement point. The blade includes a cutting edge configured to cut the material at a blade engagement point. The blade engagement point is spaced from the roller engagement point. The rotation transmission mechanism is configured to drivingly interconnect the blade and the roller such that the blade rotates faster than the roller. The roller cutter is configured such that the cutting edge applies both a compressive shear force and a tangential shear force to the material at the blade engagement point as the blade is pressed into the material and the blade and the roller rotate.

Abstract: In one embodiment, an implantable prosthetic valve includes a body that defines an inlet end and an inlet orifice, the body being constructed of a flexible biocompatible material, an outlet that extends from the body and that defines an outlet end and an outlet orifice, the outlet being constructed of a flexible biocompatible material, and an inner passage that extends through the body and the outlet from the inlet orifice to the outlet orifice to enable fluid to flow through the valve, wherein the outlet orifice is open when the valve is in its natural unloaded state and is closed when fluid pressure is applied to the outlet from a position downstream of the outlet.