Patents by Inventor Prem Sinha

Prem Sinha has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Modified template-independent enzymes for polydeoxynucleotide synthesis
    Patent number: 11390858
    Abstract: The invention includes methods for identifying polymerases, such as modified terminal nucleotidyl transferases (TdT), that are capable of binding nucleotides comprising removable 3?-O-blocking moieties to a nucleic acid initiator, without the use of a template. The invention further includes the identified polymerases, and methods of using the polymerases for de novo synthesis of predetermined oligonucleotide sequences.
    Type: Grant
    Filed: June 3, 2020
    Date of Patent: July 19, 2022
    Assignee: Molecular Assemblies, Inc.
    Inventors: Julie L. Tubbs, Prem Sinha, Boguslaw Stec, Christopher Wilson, J. William Efcavitch, Deanne W. Sammond
  • MODIFIED TEMPLATE-INDEPENDENT ENZYMES FOR POLYDEOXYNUCLEOTIDE SYNTHESIS
    Publication number: 20210009969
    Abstract: The invention includes methods for identifying polymerases, such as modified terminal nucleotidyl transferases (TdT), that are capable of binding nucleotides comprising removable 3?-O-blocking moieties to a nucleic acid initiator, without the use of a template. The invention further includes the identified polymerases, and methods of using the polymerases for de novo synthesis of predetermined oligonucleotide sequences.
    Type: Application
    Filed: June 3, 2020
    Publication date: January 14, 2021
    Inventors: Julie L. Tubbs, Prem Sinha, Boguslaw Stec, Christopher Wilson, J. William Efcavitch, Deanne W. Sammond
  • Modified template-independent enzymes for polydeoxynucleotide synthesis
    Patent number: 10774316
    Abstract: The invention includes methods for identifying polymerases, such as modified terminal nucleotidyl transferases (TdT), that are capable of binding nucleotides comprising removable 3?-O-blocking moieties to a nucleic acid initiator, without the use of a template. The invention further includes the identified polymerases, and methods of using the polymerases for de novo synthesis of predetermined oligonucleotide sequences.
    Type: Grant
    Filed: October 19, 2018
    Date of Patent: September 15, 2020
    Assignee: Molecular Assemblies, Inc.
    Inventors: J. William Efcavitch, Julie L. Tubbs, Prem Sinha, Boguslaw Stec
  • Modified template-independent enzymes for polydeoxynucleotide synthesis
    Patent number: 10760063
    Abstract: The invention includes methods for identifying polymerases, such as modified terminal nucleotidyl transferases (TdT), that are capable of binding nucleotides comprising removable 3?-O-blocking moieties to a nucleic acid initiator, without the use of a template. The invention further includes the identified polymerases, and methods of using the polymerases for de novo synthesis of predetermined oligonucleotide sequences.
    Type: Grant
    Filed: August 27, 2018
    Date of Patent: September 1, 2020
    Assignee: Molecular Assemblies, Inc.
    Inventors: J. William Efcavitch, Julie L. Tubbs, Prem Sinha, Boguslaw Stec
  • MODIFIED TEMPLATE-INDEPENDENT ENZYMES FOR POLYDEOXYNUCLEOTIDE SYNTHESIS
    Publication number: 20200190490
    Abstract: The invention includes methods for identifying polymerases, such as modified terminal nucleotidyl transferases (TdT), that are capable of binding nucleotides comprising removable 3?-O-blocking moieties to a nucleic acid initiator, without the use of a template. The invention further includes the identified polymerases, and methods of using the polymerases for de novo synthesis of predetermined oligonucleotide sequences.
    Type: Application
    Filed: August 27, 2018
    Publication date: June 18, 2020
    Inventors: J. William Efcavitch, Julie L. Tubbs, Prem Sinha, Boguslaw Stec
  • MODIFIED TEMPLATE-INDEPENDENT ENZYMES FOR POLYDEOXYNUCLEOTIDE SYNTHESIS
    Publication number: 20200190491
    Abstract: The invention includes methods for identifying polymerases, such as modified terminal nucleotidyl transferases (TdT), that are capable of binding nucleotides comprising removable 3?-O-blocking moieties to a nucleic acid initiator, without the use of a template. The invention further includes the identified polymerases, and methods of using the polymerases for de novo synthesis of predetermined oligonucleotide sequences.
    Type: Application
    Filed: October 19, 2018
    Publication date: June 18, 2020
    Inventors: J. William Efcavitch, Julie L. Tubbs, Prem Sinha, Boguslaw Stec