Patents by Inventor Premkumar Christadoss

Premkumar Christadoss has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10093743
    Abstract: Provided herein is a method of diagnosing muscle specific tyrosine kinase specific autoimmune myasthenia gravis in an individual. Generally, in the method a level of muscle specific tyrosine kinase binding to B cells is determined in a sample from an individual. A significant increase in the level of muscle specific tyrosine kinase reactive B-cells compared to that in a healthy individual indicates the presence of muscle specific tyrosine kinase autoimmune myasthenia gravis. Also provided is a fluorophore-muscle specific tyrosine kinase conjugate and a kit comprising the same useful to test the frequency of muscle specific tyrosine kinase binding B cells expressing specific markers, for diagnosis or as biomarker for muscle specific tyrosine kinase autoimmune myasthenia gravis.
    Type: Grant
    Filed: August 26, 2015
    Date of Patent: October 9, 2018
    Inventor: Premkumar Christadoss
  • Publication number: 20160137741
    Abstract: Provided herein is a method of diagnosing muscle specific tyrosine kinase specific autoimmune myasthenia gravis in an individual. Generally, in the method a level of muscle specific tyrosine kinase binding to B cells is determined in a sample from an individual. A significant increase in the level of muscle specific tyrosine kinase reactive B-cells compared to that in a healthy individual indicates the presence of muscle specific tyrosine kinase autoimmune myasthenia gravis. Also provided is a fluorophore-muscle specific tyrosine kinase conjugate and a kit comprising the same useful to test the frequency of muscle specific tyrosine kinase binding B cells expressing specific markers, for diagnosis or as biomarker for muscle specific tyrosine kinase autoimmune myasthenia gravis.
    Type: Application
    Filed: August 26, 2015
    Publication date: May 19, 2016
    Inventor: Premkumar Christadoss
  • Patent number: 8530245
    Abstract: Disclosed are methods, compositions, and diagnostic kits for detecting acetylcholine receptor (AchR) autoreactive immune cells in a subject. The methods comprise detecting the binding of AChR-conjugate to penpheral blood AChR-specific B cells for diagnosing autoimmune disorders, including Myasthenia gravis (MG), systemic lupus erythematous (SLE), and rheumatoid arthritis (RA). More specifically, the detection is achieved by using flow cytometric assay with Alexa-conjugated AchR.
    Type: Grant
    Filed: July 29, 2009
    Date of Patent: September 10, 2013
    Assignee: The Board of Regents of the University of Texas System
    Inventors: Premkumar Christadoss, Windy R. Allman
  • Patent number: 8501705
    Abstract: Disclosed are methods for treating an autoimmune and/or complement mediated disease or condition in a subject. The methods include administering to the subject a compound which inhibits the subject's classical complement pathway. The methods include administering to the subject a compound which inhibits the subject's classical complement pathway. Compositions which include inhibitors of C1q, C1r, C1s, C2 or C4 and a pharmaceutically acceptable excipient are also described.
    Type: Grant
    Filed: December 23, 2010
    Date of Patent: August 6, 2013
    Assignee: The Board of Regents of the University of Texas System
    Inventors: Premkumar Christadoss, Erdem Tuzun
  • Publication number: 20110237688
    Abstract: Disclosed are methods, compositions, and diagnostic kits for detecting acetylcholine receptor (AchR) autoreactive immune cells in a subject. The methods comprise detecting the binding of AChR-conjugate to penpheral blood AChR-specific B cells for diagnosing autoimmune disorders, including Myasthenia gravis (MG), systemic lupus erythematous (SLE), and rheumatoid arthritis (RA). More specifically, the detection is achieved by using flow cytometric assay with Alexa-conjugated AchR.
    Type: Application
    Filed: July 29, 2009
    Publication date: September 29, 2011
    Applicant: The Board of Regents of the University of Texas System
    Inventors: Premkumar Christadoss, Windy Allman
  • Publication number: 20110104156
    Abstract: Disclosed are methods for treating an autoimmune and/or complement mediated disease or condition in a subject. The methods include administering to the subject a compound which inhibits the subject's classical complement pathway. The methods include administering to the subject a compound which inhibits the subject's classical complement pathway. Compositions which include inhibitors of C1q, C1r, C1s, C2 or C4 and a pharmaceutically acceptable excipient are also described.
    Type: Application
    Filed: December 23, 2010
    Publication date: May 5, 2011
    Inventors: Premkumar Christadoss, Erdem Tuzun
  • Patent number: 7923010
    Abstract: Disclosed are methods for treating an autoimmune disease or condition in a subject. The methods include administering to the subject a compound which inhibits the subject's classical complement pathway. Also disclosed are methods for suppressing hyperacute graft rejection in a subject. The methods include administering to the subject a compound which inhibits the subject's classical complement pathway. Compositions which include a specific inhibitor of C1q and a pharmaceutically acceptable excipient are also described.
    Type: Grant
    Filed: September 11, 2004
    Date of Patent: April 12, 2011
    Assignee: The Board of Regents of the University of Texas System
    Inventors: Premkumar Christadoss, Erdem Tuzun
  • Publication number: 20070243187
    Abstract: Disclosed are methods for treating an autoimmune disease or condition in a subject. The methods include administering to the subject a compound which inhibits the subject's classical complement pathway. Also disclosed are methods for suppressing hyperacute graft rejection in a subject. The methods include administering to the subject a compound which inhibits the subject's classical complement pathway. Compositions which include a specific inhibitor of C1q and a pharmaceutically acceptable excipient are also described.
    Type: Application
    Filed: September 11, 2004
    Publication date: October 18, 2007
    Inventors: Premkumar Christadoss, Erdem Tuzun