Patents by Inventor Prerna Sharma

Prerna Sharma has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Monomeric self-associating fusion polypeptides and therapeutic uses thereof
    Patent number: 7666622
    Abstract: Monomeric fusion polypeptides comprising R1-M-L-M, wherein R1 is a target ligand-binding domain, M is a multimerizing component, and L is a linker capable of allowing one M component to interact with the other M component to form a self-associating monomer, optionally comprising a second target ligand-binding domain R2. Preferred target ligands include interleukin (IL)-13, IL-1, insulin-like growth factor (IGF)-1 and IGF-2.
    Type: Grant
    Filed: October 18, 2006
    Date of Patent: February 23, 2010
    Assignee: Regeneron Pharmaceuticals, Inc.
    Inventors: Prerna Sharma, Margaret Karow
  • Interferon-? antagonists and therapeutic uses thereof
    Patent number: 7608430
    Abstract: Polypeptides and multimeric polypeptides capable of binding interferon ? which are useful therapeutically in methods of treating interferon ?-related conditions or diseases.
    Type: Grant
    Filed: July 6, 2006
    Date of Patent: October 27, 2009
    Assignee: Regeneron Pharmaceuticals, Inc.
    Inventors: Margaret Karow, Prerna Sharma
  • IL-18 specific polypeptides and therapeutic uses thereof
    Patent number: 7557084
    Abstract: Fusion polypeptides and multimeric fusion polypeptides capable of binding interleukin-18 (IL-18) with high affinity, as well as nucleic acids encoding the IL-18-specific polypeptides, which are useful therapeutically in methods of treating IL-18-related conditions or diseases. The IL-18-specific polypeptides may include components derived from IL-18 binding protein (IL-18BP), a fusion component F, an IL-18 receptor, and/or a human interleukin-1 receptor accessory protein (hIL-1RAcP).
    Type: Grant
    Filed: March 31, 2005
    Date of Patent: July 7, 2009
    Assignee: Regeneron Pharmaceuticals, Inc.
    Inventors: Margaret Karow, Prerna Sharma
  • Monomeric self-associating fusion polypeptides and therapeutic uses thereof
    Publication number: 20070087411
    Abstract: Monomeric fusion polypeptides comprising R1-M-L-M, wherein R1 is a target ligand-binding domain, M is a multimerizing component, and L is a linker capable of allowing one M component to interact with the other M component to form a self-associating monomer, optionally comprising a second target ligand-binding domain R2. Preferred target ligands include interleukin (IL)-13, IL-1, insulin-like growth factor (IGF)-1 and IGF-2.
    Type: Application
    Filed: October 18, 2006
    Publication date: April 19, 2007
    Inventors: Prerna Sharma, Margaret Karow
  • Interferon-gamma antagonists and therapeutic uses thereof
    Publication number: 20070020283
    Abstract: Polypeptides and multimeric polypeptides capable of binding interferon ? which are useful therapeutically in methods of treating interferon ?-related conditions or diseases.
    Type: Application
    Filed: July 6, 2006
    Publication date: January 25, 2007
    Inventors: Margaret Karow, Prerna Sharma
  • IL-18 specific polypeptides and therapeutic uses thereof
    Publication number: 20050221433
    Abstract: Fusion polypeptides and multimeric fusion polypeptides capable of binding interleukin-18 (IL-18) with high affinity, as well as nucleic acids encoding the IL-18-specific polypeptides, which are useful therapeutically in methods of treating IL-18-related conditions or diseases. The IL-18-specific polypeptides may include components derived from IL-18 binding protein (IL-18BP), a fusion component F, an IL-18 receptor, and/or a human interleukin-1 receptor accessory protein (hIL-1RAcP).
    Type: Application
    Filed: March 31, 2005
    Publication date: October 6, 2005
    Inventors: Margaret Karow, Prerna Sharma