Patents by Inventor Preston B. Moore

Preston B. Moore has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods, systems, and computer program products for simulating biomembrances using coarse grain models
    Patent number: 8234074
    Abstract: A coarse grain model that mimics a lipid molecule, such as dimyristoylphosphatidylcholine (DMPC), is used to simulate self-assembly of a lamellar bilayer starting from a disordered configuration. The coarse grain model is orders of magnitude less demanding of CPU time compared to all-atom models. An initial bilayer-like structure is generated from a disordered configuration of the coarse grain models using a Monte Carlo simulation. The initial bilayer-like structure is refined using a molecular dynamics simulation. For relatively small systems, the molecular dynamics simulation can be performed under constant volume or constant pressure conditions. For larger systems, the molecular dynamics simulation is preferably performed under constant pressure conditions.
    Type: Grant
    Filed: June 12, 2003
    Date of Patent: July 31, 2012
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: Carlos F. Lopez, Steven O. Nielsen, Preston B. Moore, Michael L. Klein
  • Methods, systems, and computer program products for simulating biomembrances using coarse grain models
    Publication number: 20040102941
    Abstract: A coarse grain model that mimics a lipid molecule, such as dimyristoylphosphatidylcholine (DMPC), is used to simulate self-assembly of a lamellar bilayer starting from a disordered configuration. The coarse grain model is orders of magnitude less demanding of CPU time compared to all-atom models. An initial bilayer-like structure is generated from a disordered configuration of the coarse grain models using a Monte Carlo simulation. The initial bilayer-like structure is refined using a molecular dynamics simulation. For relatively small systems, the molecular dynamics simulation can be performed under constant volume or constant pressure conditions. For larger systems, the molecular dynamics simulation is preferably performed under constant pressure conditions.
    Type: Application
    Filed: June 12, 2003
    Publication date: May 27, 2004
    Applicant: The Trustees of the University of Pennsylvania
    Inventors: Carlos F. Lopez, Steven O. Nielsen, Preston B. Moore, Michael L. Klein