Patents by Inventor Preston Keusch

Preston Keusch has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20100191216
    Abstract: The use of an iontophoresis electrode assembly for delivery of a drug formulation is described. The drug formulation includes an anaesthetic and a vasoconstrictor. It is administered to a patient prior to a procedure to produce clinically acceptable depth and duration of dermal anaesthesia at the portion of skin to subject to a painful procedure or to reduce or eliminate pain. The procedure is one selected from the group consisting of venipuncture, IV cannulation, needle aspirations, body piercings, blood donations, electrolysis, tattoo removal, tattoo application, injections, dermabrasion, skin peeling, high velocity particle ablation, pace maker implantation, pace maker replacement, epidural puncture, lumbar puncture, regional nerve blocks, skin harvesting, small skin incisions, skin biopsies, circumcisions or excisions. The iontophoresis electrode assembly may also be used to reduce or temporarily eliminate neuropathic pain.
    Type: Application
    Filed: June 26, 2009
    Publication date: July 29, 2010
    Inventors: Preston Keusch, Vilambi Nrk Reddy, Richard Greene, George M. Baskinger, Ashutosh Sharma
  • Publication number: 20100106074
    Abstract: Provided are various embodiments of integrated electrode devices, assemblies and systems structured for use in association with electrically assisted delivery devices configured for delivery of a composition to a membrane. The integrated electrode devices, assemblies and systems include one or more of a variety of structural, physical, mechanical, electrical and electromechanical enhancements.
    Type: Application
    Filed: May 26, 2009
    Publication date: April 29, 2010
    Inventors: Vilambi NRK Reddy, Preston Keusch, Robert J. Strowe, Jeffrey Kapec, Kazuna Tanaka
  • Publication number: 20090312688
    Abstract: A shelf-stable electrically assisted transdermal drug delivery system for highly effective electrotransport of an anesthetic and a vasoconstrictor producing clinically acceptable dermal anesthesia and sensation is provided. In certain embodiments the anesthetic includes lidocaine and the vasoconstrictor includes epinephrine. Medicament delivery is affected to provide dermal anesthesia with little or no sensation during delivery, as measured by a variety of indicator tests. Methods of producing dermal anesthesia in patients are also provided.
    Type: Application
    Filed: January 16, 2009
    Publication date: December 17, 2009
    Applicant: Vyteris, Inc.
    Inventors: Vilambi NRK Reddy, Preston Keusch
  • Patent number: 7252856
    Abstract: A process for fabricating a water-swellable porous plastic plug is provided, the process including the steps of: providing a porous substrate having a plurality of passageways therethrough, disposing into the passageways a hydrophilic polymer, irradiating the substrate to induce cross-linking of the hydrophilic polymer, such that the polymer forms a hydrogel coating on the walls of the passageways.
    Type: Grant
    Filed: July 23, 2003
    Date of Patent: August 7, 2007
    Assignee: Becton, Dickinson and Company
    Inventors: Richmond R. Cohen, Preston Keusch
  • Publication number: 20070093743
    Abstract: An electrically assisted transdermal drug delivery system for highly effective electrotransport of an anesthetic and a vasoconstrictor producing clinically acceptable depth and duration of dermal anesthesia at a treatment site. In certain embodiments, the anesthetic comprises lidocaine and the vasoconstrictor comprises epinephrine.
    Type: Application
    Filed: September 27, 2006
    Publication date: April 26, 2007
    Applicant: Vyteris, Inc.
    Inventors: Preston Keusch, Vilambi Reddy, Ashutosh Sharma, George Baskinger
  • Publication number: 20070078373
    Abstract: Provided are various embodiments of integrated electrode devices, assemblies and systems structured for use in association with electrically assisted delivery devices configured for delivery of a composition, such as a composition comprising gonadotropin-releasing hormone and/or related analogs through a membrane. The integrated electrode devices, assemblies and systems include one or more of a variety of structural, physical, mechanical, electrical and electromechanical enhancements. Methods of administering compositions to patients with integrated electrode devices according to various embodiments described herein are also disclosed.
    Type: Application
    Filed: September 29, 2006
    Publication date: April 5, 2007
    Applicant: Vyteris, Inc.
    Inventors: Ashutosh Sharma, Sonal Patel, Vilambi Reddy, Preston Keusch, Yogeshvar Kalia
  • Publication number: 20070078434
    Abstract: The use of an iontophoresis electrode assembly for delivery of a drug formulation is described. The drug formulation includes an anaesthetic and a vasoconstrictor. It is administered to a patient prior to a procedure to produce clinically acceptable depth and duration of dermal anaesthesia at the portion of skin to subject to a painful procedure or to reduce or eliminate pain. The procedure is one selected from the group consisting of venipuncture, IV cannulation, needle aspirations, body piercings, blood donations, electrolysis, tattoo removal, tattoo application, injections, dermabrasion, skin peeling, high velocity particle ablation, pace maker implantation, pace maker replacement, epidural puncture, lumbar puncture, regional nerve blocks, skin harvesting, small skin incisions, skin biopsies, circumcisions or excisions. The iontophoresis electrode assembly may also be used to reduce or temporarily eliminate neuropathic pain.
    Type: Application
    Filed: September 29, 2006
    Publication date: April 5, 2007
    Applicant: Vyteris, Inc.
    Inventors: Preston Keusch, Vilambi Reddy, Richard Greene, George Baskinger, Ashutosh Sharma
  • Publication number: 20070078372
    Abstract: A shelf-stable electrically assisted transdermal drug delivery system for highly effective electrotransport of an anesthetic and a vasoconstrictor producing clinically acceptable dermal anesthesia and sensation is provided. In certain embodiments the anesthetic includes lidocaine and the vasoconstrictor includes epinephrine. Medicament delivery is affected to provide dermal anesthesia with little or no sensation during delivery, as measured by a variety of indicator tests. Methods of producing dermal anesthesia in patients are also provided.
    Type: Application
    Filed: September 29, 2006
    Publication date: April 5, 2007
    Applicant: Vyteris, Inc.
    Inventors: Vilambi Reddy, Preston Keusch
  • Patent number: 7043297
    Abstract: A reservoir electrode assembly of the present invention for an iontophoretic drug delivery device includes an electrode and a hydrophilic reservoir situated in electrically conductive relation to the electrode. The hydrophilic reservoir is formed from a bibulous hydrophilic cross-linked polymeric material having a first surface and a second surface that is adhesively adherent to the electrode. The first surface of the polymeric material is releasably adhesively adherent when applied to an area of a patient's skin. The polymeric material has a cohesive strength forms an adhesive bond with a bond strength between the second surface of the polymeric material to the electrode that is greater than the cohesive strength of the polymeric material.
    Type: Grant
    Filed: January 19, 2005
    Date of Patent: May 9, 2006
    Assignee: Vyteris, Inc.
    Inventors: Preston Keusch, NRK Vilambi, Bruce Michael Eliash
  • Publication number: 20050228336
    Abstract: Highly shelf-stable electrically assisted transdermal drug delivery systems for delivering epinephrine, typically with an anesthetic such as lidocaine, are provided along with methods for making the highly shelf-stable epinephrine-containing transdermal delivery device. Highly shelf-stable packaged electrode assemblies for transdermal delivery of epinephrine also are provided.
    Type: Application
    Filed: April 7, 2004
    Publication date: October 13, 2005
    Inventors: Preston Keusch, Vilambi Reddy, Philip Green, Uday Jain
  • Publication number: 20050228335
    Abstract: Provided are various embodiments of integrated electrode devices, assemblies and systems structured for use in association with electrically assisted delivery devices configured for delivery of a composition to a membrane. The integrated electrode devices, assemblies and systems include one or more of a variety of structural, physical, mechanical, electrical and electromechanical enhancements.
    Type: Application
    Filed: April 7, 2004
    Publication date: October 13, 2005
    Inventors: Vilambi Reddy, Preston Keusch, Robert Strowe, Jeffrey Kapec, Kazuna Tanaka
  • Publication number: 20050159700
    Abstract: A reservoir electrode assembly of the present invention for an iontophoretic drug delivery device includes an electrode and a hydrophilic reservoir situated in electrically conductive relation to the electrode. The hydrophilic reservoir is formed from a bibulous hydrophilic cross-linked polymeric material having a first surface and a second surface that is adhesively adherent to the electrode. The first surface of the polymeric material is releasably adhesively adherent when applied to an area of a patient's skin. The polymeric material has a cohesive strength forms an adhesive bond with a bond strength between the second surface of the polymeric material to the electrode that is greater than the cohesive strength of the polymeric material.
    Type: Application
    Filed: January 19, 2005
    Publication date: July 21, 2005
    Inventors: Preston Keusch, Nrk Vilambi, Bruce Eliash
  • Publication number: 20050159698
    Abstract: A reservoir electrode assembly of the present invention for an iontophoretic drug delivery device includes an electrode and a hydrophilic reservoir situated in electrically conductive relation to the electrode. The hydrophilic reservoir is formed from a bibulous hydrophilic crosslinked polymeric material having a first surface and a second surface that is adhesively adherent to the electrode. The first surface of the polymeric material is releasably adhesively adherent when applied to an area of a patient's skin. The polymeric material has a cohesive strength forms an adhesive bond with a bond strength between the second surface of the polymeric material to the electrode that is greater than the cohesive strength of the polymeric material.
    Type: Application
    Filed: January 19, 2005
    Publication date: July 21, 2005
    Inventors: Preston Keusch, Nrk Vilambi, Bruce Eliash
  • Publication number: 20050159699
    Abstract: A reservoir electrode assembly of the present invention for an iontophoretic drug delivery device includes an electrode and a hydrophilic reservoir situated in electrically conductive relation to the electrode. The hydrophilic reservoir is formed from a bibulous hydrophilic cross-linked polymeric material having a first surface and a second surface that is adhesively adherent to the electrode. The first surface of the polymeric material is releasably adhesively adherent when applied to an area of a patient's skin. The polymeric material has a cohesive strength forms an adhesive bond with a bond strength between the second surface of the polymeric material to the electrode that is greater than the cohesive strength of the polymeric material.
    Type: Application
    Filed: January 19, 2005
    Publication date: July 21, 2005
    Inventors: Preston Keusch, Nrk Vilambi, Bruce Eliash
  • Publication number: 20050131338
    Abstract: A reservoir electrode assembly of the present invention for an iontophoretic drug delivery device includes an electrode and a hydrophilic reservoir situated in electrically conductive relation to the electrode. The hydrophilic reservoir is formed from a bibulous hydrophilic cross-linked polymeric material having a first surface and a second surface that is adhesively adherent to the electrode. The first surface of the polymeric material is releasably adhesively adherent when applied to an area of a patient's skin. The polymeric material has a cohesive strength forms an adhesive bond with a bond strength between the second surface of the polymeric material to the electrode that is greater than the cohesive strength of the polymeric material.
    Type: Application
    Filed: January 19, 2005
    Publication date: June 16, 2005
    Inventors: Preston Keusch, NRK Vilambi, Bruce Eliash
  • Patent number: 6862473
    Abstract: A reservoir electrode assembly of the present invention for an iontophoretic drug delivery device includes an electrode and a hydrophilic reservoir situated in electrically conductive relation to the electrode. The hydrophilic reservoir is formed from a bibulous hydrophilic cross-linked polymeric material having a first surface and a second surface that is adhesively adherent to the electrode. The first surface of the polymeric material is releasably adhesively adherent when applied to an area of a patient's skin. The polymeric material has a cohesive strength forms an adhesive bond with a bond strength between the second surface of the polymeric material to the electrode that is greater than the cohesive strength of the polymeric material.
    Type: Grant
    Filed: February 28, 2002
    Date of Patent: March 1, 2005
    Assignee: Vyteris, Inc.
    Inventors: Preston Keusch, Vilambi Nrk, Bruce Michael Eliash
  • Publication number: 20040131794
    Abstract: A blood gas syringe includes a porous plastic plug having a crosslinked hydrogel affixed to a wall of a passageway of the plug. When a blood sample is taken with the syringe, the incoming sample forces air in the system out through the passageway of the plug until the sample contacts the hydrogel, causing the passageway to seal shut.
    Type: Application
    Filed: July 23, 2003
    Publication date: July 8, 2004
    Inventors: Richmond R. Cohen, Preston Keusch
  • Patent number: 6648836
    Abstract: A blood gas syringe includes a porous plastic plug having a crosslinked hydrogel affixed to a wall of a passageway of the plug. When a blood sample is taken with the syringe, the incoming sample forces air in the system out through the passageway of the plug until the sample contacts the hydrogel, causing the passageway to seal shut.
    Type: Grant
    Filed: August 30, 2001
    Date of Patent: November 18, 2003
    Assignee: Becton, Dickinson and Company
    Inventors: Richmond R. Cohen, Preston Keusch
  • Patent number: 6635045
    Abstract: Provided is a method for loading electrode-corroding ingredients into an un-loaded donor gel reservoir of an electrode for an electrically assisted drug delivery system. The method provides that a salt, such as sodium chloride or an organic salt, is provided in the un-loaded donor gel reservoir, contrary to convention. Related electrically assisted drug delivery electrode assemblies also are provided.
    Type: Grant
    Filed: June 29, 2001
    Date of Patent: October 21, 2003
    Assignee: Vyteris, Inc.
    Inventors: Preston Keusch, Uday K. Jain, Vilambi Nrk Reddy, Bruce M. Eliash, Kevin John Carey, Vitaly Falevich
  • Patent number: 6629968
    Abstract: A reservoir-electrode for an iontophoretic delivery device of the present invention includes an electrode; and a hydrophilic reservoir situated in electrically conductive relation to the electrode. The reservoir is formed from a bibulous hydrophilic cross-linked polymeric material having a substantially uniform concentration of an alkali metal chloride salt therein thereby substantially eliminating concentration gradients of the salt with respect to the electrode. The polymeric material has a first surface and a second surface that is adhesively adherent to the electrode. The first surface of the polymeric material is releasably adhesive to an applied area of a patient's skin.
    Type: Grant
    Filed: June 30, 2000
    Date of Patent: October 7, 2003
    Assignee: Vyteris, Inc.
    Inventors: Uday K. Jain, Vilambi N R K Reddy, Bruce M. Eliash, Kevin John Carey, Vitaly Falevich, Preston Keusch