Patents by Inventor Primo{hacek over (z)} Knap
Primo{hacek over (z)} Knap has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Patent number: 11898199Abstract: The present disclosure provides, among other things, methods of screening for colorectal cancer, methods of screening for advanced adenoma, methods of screening for the presence of either colorectal cancer or advanced adenoma (or both), and compositions related thereto. In various embodiments, the present disclosure provides methods for colorectal cancer and/or advanced adenoma screening that includes analysis of methylation status of one or more methylation biomarkers, and compositions related thereto. In various embodiments, the present disclosure provides methods for colorectal cancer and/or advanced adenoma screening that include screening methylation status of one or more methylation biomarkers in cfDNA, e.g., in ctDNA. In various embodiments, the present disclosure provides methods for colorectal cancer and/or advanced adenoma screening that include screening methylation status of one or more methylation biomarkers in cfDNA, e.g., in ctDNA, using MSRE-qPCR.Type: GrantFiled: November 11, 2019Date of Patent: February 13, 2024Assignee: Universal Diagnostics, S.A.Inventors: Marko Bitenc, Kristi Kruusmaa, Juan Martinez-Barea, Christian Hense, Marko Chersicola, Primo{hacek over (z)} Knap
-
Patent number: 11396679Abstract: The present disclosure provides, among other things, methods for colorectal cancer screening and compositions related thereto. In various embodiments, the present disclosure provides methods for colorectal cancer screening that include analysis of methylation status of one or more methylation biomarkers, and compositions related thereto. In various embodiments, the present disclosure provides methods for colorectal cancer screening that include screening methylation status of one or more methylation biomarkers in cfDNA, e.g., in ctDNA. In various embodiments, the present disclosure provides methods for colorectal cancer screening that include screening methylation status of one or more methylation biomarkers in cfDNA, e.g., in ctDNA, using MSRE-qPCR.Type: GrantFiled: May 31, 2019Date of Patent: July 26, 2022Assignee: Universal Diagnostics, S.L.Inventors: Marko Bitenc, Kristi Kruusmaa, Juan Martinez-Barea, Christian Hense, Marko Chersicola, Primo{hacek over (z)} Knap
-
Publication number: 20210404011Abstract: The present disclosure provides, among other things, methods for colorectal cancer, breast cancer, lung cancer and/or pancreatic cancer detection (e.g., screening) and compositions related thereto. In various embodiments, the present disclosure provides methods for screening that include analysis of methylation status of one or more methylation biomarkers, and compositions related thereto. In various embodiments, the present disclosure provides methods for detection (e.g., screening) that include detecting (e.g., screening) methylation status of one or more methylation biomarkers in cfDNA, e.g., in ctDNA. In various embodiments, the present disclosure provides methods for screening that include detecting (e.g., screening) methylation status of one or more methylation biomarkers in cfDNA, e.g., in ctDNA, using MSRE-qPCR and/or using massively parallel sequencing (e.g., next-generation sequencing).Type: ApplicationFiled: September 21, 2020Publication date: December 30, 2021Inventors: Marko Bitenc, Kristi Kruusmaa, Juan Martinez-Barea, Christian Hense, Pol Sola de los Santos, Pol Canal Noguer, Marko Chersicola, Primo{hacek over (z)} Knap
-
Publication number: 20210404010Abstract: The present disclosure provides, among other things, methods for colorectal neoplasm detection (e.g., screening) and compositions related thereto. In various embodiments, the present disclosure provides methods for adenoma and/or early stage colorectal cancer detection (e.g., screening) and compositions related thereto. In various embodiments, the present disclosure provides methods for screening that include analysis of methylation status of one or more methylation biomarkers, and compositions related thereto. In various embodiments, the present disclosure provides methods for detection (e.g., screening) that include detecting (e.g., screening) methylation status of one or more methylation biomarkers in cfDNA, e.g., in ctDNA. In various embodiments, the present disclosure provides methods for screening that include detecting (e.g., screening) methylation status of one or more methylation biomarkers in cfDNA, e.g., in ctDNA, using MSRE-qPCR and/or using massively parallel sequencing (e.g.Type: ApplicationFiled: September 21, 2020Publication date: December 30, 2021Inventors: Marko Bitenc, Kristi Kruusmaa, Juan Martinez-Barea, Christian Hense, Pol Sola de los Santos, Pol Canal Noguer, Marko Chersicola, Primo{hacek over (z)} Knap
-
Publication number: 20210355542Abstract: Described herein are various systems, methods, and apparatus for identifying biomarkers for detection of a disease or condition such as advanced adenoma, colorectal cancer, or other cancers. In certain embodiments, the present invention relates to methods and/or systems for identifying one or more biomarkers related to methylation status in cell-free deoxyribonucleic acid (DNA) of a human subject and/or detecting (e.g., screening for) cancer based on one or more known biomarkers (e.g., the identified biomarkers).Type: ApplicationFiled: September 21, 2020Publication date: November 18, 2021Inventors: Marko Bitenc, Kristi Kruusmaa, Juan Martinez-Barea, Christian Hense, Pol Sola de los Santos, Pol Canal Noguer, Marko Chersicola, Primo{hacek over (z)} Knap
-
Publication number: 20210332440Abstract: The present disclosure provides, among other things, methods for adenoma and/or early stage colorectal cancer detection (e.g., screening) and compositions related thereto. In various embodiments, the present disclosure provides methods for screening that include analysis of methylation status of one or more methylation biomarkers, and compositions related thereto. In various embodiments, the present disclosure provides methods for detection (e.g., screening) that include detecting (e.g., screening) methylation status of one or more methylation biomarkers in cfDNA, e.g., in ctDNA. In various embodiments, the present disclosure provides methods for screening that include detecting (e.g., screening) methylation status of one or more methylation biomarkers in cfDNA, e.g., in ctDNA, using MSRE-qPCR and/or using massively parallel sequencing (e.g., next-generation sequencing).Type: ApplicationFiled: September 21, 2020Publication date: October 28, 2021Inventors: Kristi Kruusmaa, Christian Hense, Marko Bitenc, Juan Martinez-Barea, Pol Sola de los Santos, Pol Canal Noguer, Marko Chersicola, Primo{hacek over (z)} Knap
-
Publication number: 20210277487Abstract: The present disclosure provides, among other things, methods for colorectal cancer screening and compositions related thereto. In various embodiments, the present disclosure provides methods for colorectal cancer screening that include analysis of methylation status of one or more methylation biomarkers, and compositions related thereto. In various embodiments, the present disclosure provides methods for colorectal cancer screening that include screening methylation status of one or more methylation biomarkers in cfDNA, e.g., in ctDNA. In various embodiments, the present disclosure provides methods for colorectal cancer screening that include screening methylation status of one or more methylation biomarkers in cfDNA, e.g., in ctDNA, using MSRE-qPCR.Type: ApplicationFiled: May 25, 2021Publication date: September 9, 2021Inventors: Marko Bitenc, Kristi Kruusmaa, Juan Martinez-Barea, Christian Hense, Marko Chersicola, Primo{hacek over (z)} Knap
-
Patent number: 11001898Abstract: The present disclosure provides, among other things, methods for colorectal cancer detection (e.g., screening) and compositions related thereto. In various embodiments, the present disclosure provides methods for colorectal cancer screening that include analysis of methylation status of one or more methylation biomarkers, and compositions related thereto. In various embodiments, the present disclosure provides methods for colorectal cancer detection (e.g., screening) that include detecting (e.g., screening) methylation status of one or more methylation biomarkers in cfDNA, e.g., in ctDNA. In various embodiments, the present disclosure provides methods for colorectal cancer screening that include detecting (e.g., screening) methylation status of one or more methylation biomarkers in cfDNA, e.g., in ctDNA, using MSRE-qPCR.Type: GrantFiled: March 26, 2020Date of Patent: May 11, 2021Assignee: Universal Diagnostics, S.L.Inventors: Marko Bitene, Kristi Kruusmaa, Juan Martinez-Barea, Christian Hense, Pol Sola de los Santos, Pol Canal Noguer, Marko Chersicola, Primo{hacek over (z)} Knap
-
Publication number: 20200377954Abstract: The present disclosure provides, among other things, methods for colorectal cancer screening and compositions related thereto. In various embodiments, the present disclosure provides methods for colorectal cancer screening that include analysis of methylation status of one or more methylation biomarkers, and compositions related thereto. In various embodiments, the present disclosure provides methods for colorectal cancer screening that include screening methylation status of one or more methylation biomarkers in cfDNA, e.g., in ctDNA. In various embodiments, the present disclosure provides methods for colorectal cancer screening that include screening methylation status of one or more methylation biomarkers in cfDNA, e.g., in ctDNA, using MSRE-qPCR.Type: ApplicationFiled: May 31, 2019Publication date: December 3, 2020Inventors: Marko Bitenc, Kristi Kruusmaa, Juan Martinez-Barea, Christian Hense, Marko Chersicola, Primo{hacek over (z)} Knap
-
Publication number: 20200377959Abstract: The present disclosure provides, among other things, methods for colorectal cancer detection (e.g., screening) and compositions related thereto. In various embodiments, the present disclosure provides methods for colorectal cancer screening that include analysis of methylation status of one or more methylation biomarkers, and compositions related thereto. In various embodiments, the present disclosure provides methods for colorectal cancer detection (e.g., screening) that include detecting (e.g., screening) methylation status of one or more methylation biomarkers in cfDNA, e.g., in ctDNA. In various embodiments, the present disclosure provides methods for colorectal cancer screening that include detecting (e.g., screening) methylation status of one or more methylation biomarkers in cfDNA, e.g., in ctDNA, using MSRE-qPCR.Type: ApplicationFiled: March 26, 2020Publication date: December 3, 2020Inventors: Marko Bitenc, Kristi Kruusmaa, Juan Martinez-Barea, Christian Hense, Pol Sola de los Santos, Pol Canal Noguer, Marko Chersicola, Primo{hacek over (z)} Knap