Patents by Inventor Priscilla A. Schaffer

Priscilla A. Schaffer has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Combination therapy involving drugs which target cellular proteins and drugs which target pathogen-encoded proteins
    Publication number: 20030099944
    Abstract: The invention relates to the identification of cdk inhibitors as inhibitors of pathogen gene expression, replication and reactivation. The invention also relates to the identification of a combination therapy to inhibit pathogen replication in which a drug that inhibits pathogen replication by targeting a specific pathogen-encoded protein is administered in combination with a drug that inhibits pathogen replication by targeting host-encoded cdk proteins.
    Type: Application
    Filed: December 6, 2000
    Publication date: May 29, 2003
    Inventors: Priscilla A. Schaffer, Luis M. Schang
  • Cellular proteins as targets for the treatment of pathogens resistant to drugs that target pathogen-encoded proteins
    Publication number: 20030060457
    Abstract: The invention relates to the identification of cdk inhibitors as inhibitors of gene expression, replication and reactivation in pathogenic agents.
    Type: Application
    Filed: December 6, 2000
    Publication date: March 27, 2003
    Inventors: Priscilla A. Schaffer, Luis M. Schang
  • Inhibitors of microbial gene expression replication and pathogenesis
    Publication number: 20030049602
    Abstract: The invention relates to the identification of cdk inhibitors as inhibitors of microbial gene expression, replication and reactivation.
    Type: Application
    Filed: December 6, 2000
    Publication date: March 13, 2003
    Inventors: Priscilla A. Schaffer, Luis M. Schang, Robert Jordan
  • Glucocorticoid response elements
    Patent number: 6103710
    Abstract: The invention features an isolated herpesvirus glucocorticoid response element comprising a DNA sequence comprising two consensus hexanucleotide glucocorticoid receptor binding sequences having at least five nucleotides positioned therebetween. The invention further features compositions and methods for preventing herpesvirus replication and reactivation.
    Type: Grant
    Filed: April 13, 1999
    Date of Patent: August 15, 2000
    Assignee: Dana Farber Cancer Institute
    Inventors: Priscilla A. Schaffer, Mary Ann Hardwicke
  • Compositions and methods for treatment of herpesvirus infections
    Patent number: 5821339
    Abstract: A substantially pure preparation of an HSV-specific junction-spanning transcript (L/ST), wherein the 5' end of the L/ST maps to the b repeat sequences of HSV DNA at approximately 3 kb and 125 kb, wherein the L/ST extends into the c repeat sequences of HSV DNA and wherein the HSV DNA sequence encoding the L/ST is preceded by an ICP4 binding site and a TATA box.
    Type: Grant
    Filed: June 2, 1995
    Date of Patent: October 13, 1998
    Assignee: Dana Farber Cancer Institute
    Inventors: Priscilla A. Schaffer, Lily Yeh
  • Glucocorticoid response elements
    Patent number: 5665873
    Abstract: The invention features an isolated herpesvirus glucocorticoid response element comprising a DNA sequence comprising two consensus hexanucleotide glucocorticoid receptor binding sequences having at least five nucleotides positioned therebetween. The invention further features compositions and methods for preventing herpesvirus replication and reactivation.
    Type: Grant
    Filed: February 9, 1995
    Date of Patent: September 9, 1997
    Assignee: Dana Farber Cancer Institute
    Inventors: Priscilla A. Schaffer, Mary Ann Hardwicke
  • Assay for antiviral activity using complex of herpesvirus origin of replication and cellular protein
    Patent number: 5616461
    Abstract: The invention features methods and compositions useful for identifying candidate compounds for antiviral activity, useful for inhibiting replication of a DNA virus, and useful for treating an animal infected with a DNA virus.
    Type: Grant
    Filed: May 14, 1992
    Date of Patent: April 1, 1997
    Assignee: Dana-Farber Cancer Institute
    Inventors: Priscilla A. Schaffer, Christine E. Dabrowski Amaral