Abstract: Systems, devices and methods involving static or active measurement of pressure, load, or other forces exerted on or between internal anatomical structures are described. A load and/or strain sensor, which may be implantable or otherwise deployed during a medical procedure, along with systems and methods thereof, are also described. These measurements techniques and sensors can provide real-time as well as accumulated data indicative of stresses or other forces being exerted on or between internal anatomical structures of a target patient, e.g., portions or interfaces of the skeletal system.