Patents by Inventor Priscilla Purnick

Priscilla Purnick has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Engineered cellular pathways for programmed autoregulation of differentiation
    Patent number: 9458471
    Abstract: The present invention provides compositions and methods for programming mammalian cells to perform desired functions. In particular, the present invention provides compositions and methods for programming stem cells to differentiate into a desired cell type. A quorum sensing systems that regulates the expression of cell fate regulators is introduced into mammalian host cells, such as stem cells. The quorum sensing systems generally comprises vectors that express the components of a bacterial quorum sensing pathway, including proteins which catalyze the synthesis of an autoinducer and a gene encoding a regulatory partner of the autoinducer, and vectors in which genes encoding cell fate regulators are operably linked to a promoter induced by the autoinducer/regulatory partner complex.
    Type: Grant
    Filed: February 6, 2014
    Date of Patent: October 4, 2016
    Assignee: The Trustees of Princeton University
    Inventors: Ron Weiss, Ihor Lemischka, Priscilla Purnick, Christoph Schaniel, Miles Miller, Patrick Guye
  • Engineered Cellular Pathways for Programmed Autoregulation of Differentiation
    Publication number: 20140234957
    Abstract: The present invention provides compositions and methods for programming mammalian cells to perform desired functions. In particular, the present invention provides compositions and methods for programming stem cells to differentiate into a desired cell type. A quorum sensing systems that regulates the expression of cell fate regulators is introduced into mammalian host cells, such as stem cells. The quorum sensing systems generally comprises vectors that express the components of a bacterial quorum sensing pathway, including proteins which catalyze the synthesis of an autoinducer and a gene encoding a regulatory partner of the autoinducer, and vectors in which genes encoding cell fate regulators are operably linked to a promoter induced by the autoinducer/regulatory partner complex.
    Type: Application
    Filed: February 6, 2014
    Publication date: August 21, 2014
    Applicant: The Trustees of Princeton University
    Inventors: Ron Weiss, Ihor Lemischka, Priscilla Purnick
  • ENGINEERED CELLULAR PATHWAYS FOR PROGRAMMED AUTOREGULATION OF DIFFERENTIATION
    Publication number: 20100285584
    Abstract: The present invention provides compositions and methods for programming mammalian cells to perform desired functions. In particular, the present invention provides compositions and methods for programming stem cells to differentiate into a desired cell type. A quorum sensing systems that regulates the expression of cell fate regulators is introduced into mammalian host cells, such as stem cells. The quorum sensing systems generally comprises vectors that express the components of a bacterial quorum sensing pathway, including proteins which catalyze the synthesis of an autoinducer and a gene encoding a regulatory partner of the autoinducer, and vectors in which genes encoding cell fate regulators are operably linked to a promoter induced by the autoinducer/regulatory partner complex.
    Type: Application
    Filed: November 1, 2007
    Publication date: November 11, 2010
    Inventors: Ron Weiss, Ihor Lemischka, Priscilla Purnick, Christoph Schaniel, Miles Miller, Patrick Guye