Patents by Inventor Prithipal Singh
Prithipal Singh has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 4489156Abstract: Chloramphenicol derivatives are provided for use in the preparing of antigen conjugates for the production of antibodies specifically for chloramphenicol. Specifically, the aryl amino group is derivatized to introduce a non-oxocarbonyl group which is used for amide formation with an antigen. The conjugate is then injected into a vertebrate for production of antisera which is isolated in conventional ways and find particular use in competitive protein binding assays.Type: GrantFiled: April 23, 1981Date of Patent: December 18, 1984Assignee: Syva CompanyInventors: Pyare Khanna, Evan S. Snyder, Prithipal Singh
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Patent number: 4489157Abstract: Chloramphenicol derivatives are provided for use in the preparing of antigen conjugates for the production of antibodies specifically for chloramphenicol. Specifically, the aryl amino group is derivatized to introduce a non-oxocarbonyl group which is used for amide formation with an antigen. The conjugate is then injected into a vertebrate for production of antisera which is isolated in conventional ways and finds particular use in competitive protein binding assays.Type: GrantFiled: September 28, 1981Date of Patent: December 18, 1984Assignee: Syva CompanyInventors: Pyare L. Khanna, Evan S. Snyder, Prithipal Singh
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Patent number: 4446065Abstract: Novel oxime derivatives of phencyclidine are provided as precursors for conjugating proteins, either antigenic for the preparation of antibodies or enzymatic for the preparation of enzyme conjugates, which antibodies and enzyme conjugates find use as reagents in immunoassays. The combination of antibodies and enzyme conjugates provide for sensitive, accurate, rapid assays for phencyclidine without interference from commonly administered drugs, such as dextromethorphan, demerol and chlorpromazine.Type: GrantFiled: December 22, 1981Date of Patent: May 1, 1984Assignee: Syva CompanyInventors: Cheng-I Lin, Prithipal Singh
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Patent number: 4409325Abstract: .alpha.-substituted derivatives of valproic acid are provided for conjugation to antigenic compositions, particularly poly(amino acids), and enzymes. The antigenic conjugates are employed for the production of antibodies, which find particular use in immunoassays for the determination of valproate, while the enzyme conjugate finds use in a homogeneous enzyme immunoassay for the determination of valproate. The compounds are synthesized by alkylating valproate at the tertiary carbon atom by an aliphatic chain with a terminal double bond which is cleaved to provide an acid or aldehyde group.Type: GrantFiled: December 21, 1981Date of Patent: October 11, 1983Assignee: Syva CompanyInventors: Danton K. Leung, Prithipal Singh
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Patent number: 4329502Abstract: Compounds are provided which can be used in the preparation of reagents useful for quantitatively determining the presence of b-adrenergic blocking agents. These compounds contain a derivative of the blocking agent which is linked to an antigen or enzyme, the antigen conjugates being useful for preparing antibodies, and the enzyme conjugates being useful as detectors in an immunoassay as well. Additionally carboxylic acids, esters and aldehydes which are derivatives of the blocking agents are provided which are useful in preparing the above conjugates.Type: GrantFiled: August 7, 1980Date of Patent: May 11, 1982Assignee: Syva CompanyInventors: Prithipal Singh, Marcel R. Pirio
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Patent number: 4328311Abstract: Methods and compositions are provided for conjugating a wide variety of compounds, particularly polyfunctional compounds, having a mercapto group, either naturally present or synthetically introduced, to a polyamino compound, particularly a polypeptide (including proteins). The method employs a haloalkyl-carbonyl compound, which is conjugated to one or more of the amino groups under mild acylating conditions. This is followed by combining the acylated polyamino compound with a mercapto containing compound, whereby the halogen is displaced by the sulfur of the mercapto group to form a stable thioether linkage. The resulting conjugates, depending on the compounds involved, can find uses in immunoassays, as hapten-antigen conjugates for the production of antibodies, and as ligand analog enzyme conjugates for use as reagents in controlling the distribution of substitution of a mercapto compound to a polyamino compound.Type: GrantFiled: February 28, 1980Date of Patent: May 4, 1982Assignee: Syva CompanyInventors: Gerald L. Rowley, Danton Leung, Prithipal Singh
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Patent number: 4323507Abstract: .alpha.-substituted derivatives of valproic acid are provided for conjugation to antigenic compositions, particularly poly(amino acids), and enzymes. The antigenic conjugates are employed for the production of antibodies, which find particular use in immunoassays for the determination of valproate, while the enzyme conjugate finds use in a homogeneous enzyme immunoassay for the determination of valproate. The compounds are synthesized by alkylating valproate at the tertiary carbon atom by an aliphatic chain with a terminal double bond which is cleaved to provide an acid or aldehyde group.Type: GrantFiled: July 14, 1980Date of Patent: April 6, 1982Assignee: Syva CompanyInventors: Danton K. Leung, Prithipal Singh
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Patent number: 4307245Abstract: Amitriptyline functionalized compounds are provided for conjugation to antigenic compositions, particularly poly(amino acids), and enzymes. The antigenic conjugates are employed for the production of antibodies, which find particular use in immunoassays for the determination of amitriptyline, while the enzyme conjugate finds use in a homogeneous enzyme immunoassay for the determination of amitriptyline.Type: GrantFiled: April 7, 1980Date of Patent: December 22, 1981Assignee: Syva CompanyInventors: Mae W. Hu, Prithipal Singh
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Patent number: 4288553Abstract: Novel carboxyalkylated disopyramides (NORPACE.RTM.) are provided as precursors for conjugating proteins, either antigenic for the preparation of antibodies or enzymatic for the preparation of enzyme conjugates, which antibodies and enzyme conjugates find use as reagents in immunoassays. The combination of antibodies and enzyme conjugates provide for sensitive, accurate, rapid assays for disopyramide without interference from closely analogous compounds, such as methadone or disopyramides metabolites.Type: GrantFiled: February 11, 1980Date of Patent: September 8, 1981Assignee: Syva CompanyInventors: Prithipal Singh, Pyare L. Khanna, Floyd W. Colvin
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Patent number: 4281065Abstract: Phencylidine, PCP, derivatives having a non-oxo carbonyl functionality linked directly or through a linking group to the phenyl ring are provided for conjugation to antigenic compositions, particularly poly(amino acids), and enzymes. The antigenic conjugates are employed for the production of antibodies, which find particular use in immunoassays for the determination of phencyclidine, while the enzyme conjugate finds use in a homogeneous enzyme immunoassay for the determination of phencyclidine.Type: GrantFiled: January 25, 1979Date of Patent: July 28, 1981Assignee: Syva CompanyInventors: Cheng-I Lin, Prithipal Singh
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Patent number: 4275160Abstract: Imipramine functionalized compounds are provided for conjugation to antigenic compounds, particularly poly(amino acids), and enzymes. The antigenic conjugates are employed for the production of antibodies, which find particular use in immunoassays for the determination of imipramine, while the enzyme conjugate finds use in a homogeneous enzyme assay for the determination of imipramine.Type: GrantFiled: July 6, 1979Date of Patent: June 23, 1981Assignee: Syva CompanyInventors: Prithipal Singh, Marcel R. Pirio
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Patent number: 4262089Abstract: Theophylline derivatives are provided for preparing reagents for use in competitive protein binding assays and for use as reagents in competitive protein binding assays. Theophylline is substituted at the 3 position and conjugated to antigens for production of antibodies which specifically recognize theophylline as distinct from structurally similar analogs such as caffeine. Enzyme conjugates are provided which find use for measuring the amount of theophylline in a sample suspected of containing theophylline. A method is provided employing the reagents for the determination of theophylline.Type: GrantFiled: April 7, 1980Date of Patent: April 14, 1981Assignee: Syva CompanyInventors: Prithipal Singh, Mae W. Hu
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Patent number: 4241177Abstract: Compounds are provided which can be used in the preparation of reagents useful for quantitatively determining the presence of .beta.-adrenergic blocking agents. These compounds contain a derivative of the blocking agent which is linked to an antigen or enzyme, the antigen conjugates being useful for preparing antibodies, and the enzyme conjugates being useful as detectors in an immunoassay as well. Additionally carboxylic acids, esters and aldehydes which are derivatives of the blocking agents are provided which are useful in preparing the above conjugates.Type: GrantFiled: August 28, 1978Date of Patent: December 23, 1980Assignee: Syva CompanyInventors: Prithipal Singh, Marcel R. Pirio
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Patent number: 4238389Abstract: .alpha.-substituted derivatives of valproic acid are provided for conjugation to antigenic compositions, particularly poly(amino acids), and enzymes. The antigenic conjugates are employed for the production of antibodies, which find particular use in immunoassays for the determination of valproate, while the enzyme conjugate finds use in a homogeneous enzyme immunoassay for the determination of valproate. The compounds are synthesized by alkylating valproate at the tertiary carbon atom by an aliphatic chain with a terminal double bond which is cleaved to provide an acid or aldehyde group.Type: GrantFiled: February 12, 1979Date of Patent: December 9, 1980Assignee: Syva CompanyInventors: Danton K. Leung, Prithipal Singh
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Patent number: 4235969Abstract: Compounds are provided for use in the preparation of reagents which can be used in immunoassays for the determination of benzamides of N,N-dialkylethyleneamines. A linking group is provided, at a particular site of the drug, which provides a link between the above compounds and an antigen, with the resulting conjugate being employed for the preparation of antibodies. The antibodies find particular use in competitive protein binding assays. Conjugates to enzymes are prepared which find particular use in homogeneous enzyme immunoassays.Type: GrantFiled: May 8, 1978Date of Patent: November 25, 1980Assignee: Syva CompanyInventors: Prithipal Singh, Marcel R. Pirio
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Patent number: 4230805Abstract: Theophylline derivatives are provided for preparing reagents for use in competitive protein binding assays and for use as reagents in competitive protein binding assays. Theophylline is substituted at the 3 position and conjugated to antigens for production of antibodies which specifically recognize theophylline as distinct from structurally similar analogs such as caffeine. Enzyme conjugates are provided which find use for measuring the amount of theophylline in a sample suspected of containing theophylline. A method is provided employing the reagents for the determination of theophylline.Type: GrantFiled: January 11, 1979Date of Patent: October 28, 1980Assignee: Syva CompanyInventors: Prithipal Singh, Mae W. Hu
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Patent number: 4223013Abstract: Amitriptyline functionalized compounds are provided for conjugation to antigenic compositions, particularly poly(amino acids), and enzymes. The antigenic conjugates are employed for the production of antibodies, which find particular use in immunoassays for the determination of amitriptyline, while the enzyme conjugate finds use in a homogeneous enzyme immunoassay for the determination of amitriptyline.Type: GrantFiled: December 29, 1978Date of Patent: September 16, 1980Assignee: Syva CompanyInventors: Mae W. Hu, Prithipal Singh
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Patent number: 4156081Abstract: Theophylline derivatives are provided for preparing reagents for use in competitive protein binding assays and for use as reagents in competitive protein binding assays. Theophylline is substituted at the 3 position and conjugated to antigens for production of antibodies which specifically recognize theophylline as distinct from structurally similar analogs such as caffeine. Enzyme conjugates are provided which find use for measuring the amount of theophylline in a sample suspected of containing theophylline. A method is provided employing the reagents for the determination of theophylline.Type: GrantFiled: April 15, 1977Date of Patent: May 22, 1979Assignee: Syva CompanyInventors: Prithipal Singh, Mae W. Hu
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Patent number: 4069105Abstract: Derivatives of anesthetics involving anilides, lidocaine being illustrative, are provided, having an annular amino group. A difunctional linking group is provided, which provides a link to the annular amino group and an antigen, with the resulting conjugate being employed for the preparation of antibodies. The antibodies find particular use in competitive protein binding assays. Conjugates to enzymes are prepared which find particular use in homogeneous enzyme immunoassays.Type: GrantFiled: March 3, 1977Date of Patent: January 17, 1978Assignee: Syva CompanyInventor: Prithipal Singh
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Patent number: 4058511Abstract: Derivatives of dibenz[b,f]azepine drugs are provided for preparation of antigens and antibodies, the antibodies finding use in immunoassays for the dibenz[b,f]azepine drugs. Specifically, N-oxoaliphatic substituted carbamoyl dibenz[b,f]azepine compounds are provided which are conjugated with antigenic materials and injected into animals for production of antibodies specific for the azepine drug.Type: GrantFiled: January 12, 1976Date of Patent: November 15, 1977Assignee: Syva CompanyInventor: Prithipal Singh