Abstract: Disclosed herein are devices and methods for delivering a predetermined volume of a drug substance or other product including a fluid. An exemplary device may include a body configured to receive a drug substance therein, and a plunger rod disposed at least partially inside the body to distally move a stopper in the body. The device may include a component configured to regulate distal movement of the plunger rod in a priming step and in a subsequent delivery step, so that the device may be accurately primed and may accurately dispense a predetermined volume of a drug substance.

Abstract: A method of detecting one or more well interference events at a well penetrating a reservoir in a subterranean formation is provided. The method includes: receiving wellhead pressure and flowrates of oil, gas, and water for the well during production; calculating a bottom hole pressure (BHP) of the well based on the wellhead pressure and flowrate of oil, gas, and water; calculating an average reservoir pressure based at least on the BHP; determining a productivity index (PI) for the well for a plurality of time steps based at least on the average reservoir pressure; determining a dataset of PI values and corresponding cumulative fluid production values from the well; analyzing the dataset to determine one or more breakpoints in a relationship between PI and cumulative fluid production representing one or more well interference events; and producing fluids from the reservoir based at least on the one or more breakpoints.

Abstract: A method of forecasting production of a well penetrating a reservoir in a subterranean formation, including: receiving a plurality of bottomhole pressures for the well; receiving a plurality of flowrates for the well; determining rate normalized pressure (RNP) data for the well over a period of time based on the plurality of bottomhole pressure and the plurality of flowrates; performing a sparse identification of nonlinear dynamics (SINDy) analysis on the RNP data to identify a relationship between flowrate and bottomhole pressure for the well, wherein the SINDy analysis is based on a plurality of physics features; providing a forecast of future production for the well based on the identified relationship between flowrate and bottomhole pressure for the well; and producing fluids from the reservoir based, at least in part, on the forecast of future production.

Abstract: Disclosed herein are methods for analyzing one or more analytes of a cell by performing single-cell analysis. In one scenario, the one or more analytes are located on a surface of the cell. In one scenario, the one or more analytes are located internally within the cell. In one scenario, the one or more analytes include proteins located on a surface of the cell and located internally within the cell.

Abstract: A vial adapter assembly that includes a housing, a first receptacle formed within the housing and configured to receive a first vial within the housing, and a second receptacle formed within the housing and configured to receive a second vial within the housing. An opening of the first receptacle and an opening of the second receptacle is in fluid communication with the upper surface of the housing. The vial adapter assembly includes a cap that is coupled and movable relative to the housing from a closed configuration to an open configuration. In the closed configuration, the cap is configured to cover the opening of the first receptacle and the opening of the second receptacle on the upper surface. In the open configuration, the cap is configured to uncover the opening of the first receptacle and the opening of the second receptacle, and expose the upper surface.

Abstract: Disclosed herein are devices and methods for delivering a predetermined volume of a drug substance or other product including a fluid. An exemplary device may include a body configured to receive a drug substance therein, and a plunger rod disposed at least partially inside the body to distally move a stopper in the body. The device may include a component configured to regulate distal movement of the plunger rod in a priming step and in a subsequent delivery step, so that the device may be accurately primed and may accurately dispense a predetermined volume of a drug substance.

Abstract: Disclosed herein are devices and methods for delivering a predetermined volume of a drug substance or other product including a fluid. An exemplary device may include a body configured to receive a drug substance therein, and a plunger rod disposed at least partially inside the body to distally move a stopper in the body. The device may include a component configured to regulate distal movement of the plunger rod in a priming step and in a subsequent delivery step, so that the device may be accurately primed and may accurately dispense a predetermined volume of a drug substance.

Abstract: Disclosed herein are devices and methods for delivering a predetermined volume of a drug substance or other product including a fluid. An exemplary device may include a body configured to receive a drug substance therein, and a plunger rod disposed at least partially inside the body to distally move a stopper in the body. The device may include a component configured to regulate distal movement of the plunger rod in a priming step and in a subsequent delivery step, so that the device may be accurately primed and may accurately dispense a predetermined volume of a drug substance.

Abstract: According to one aspect of the disclosure, an apparatus for manipulating a sclera to facilitate delivery of a medicament to a suprachoroidal space of an eye may include a needle with a sharp distalmost tip, a needle hub connected to a proximal end of the needle, a housing surrounding the needle hub and extending from a proximal end of the needle hub, and an adaptor surrounding a portion of the needle.

Abstract: Disclosed herein are devices and methods for delivering a predetermined volume of a drug substance or other product including a fluid. An exemplary device may include a body configured to receive a drug substance therein, and a plunger rod disposed at least partially inside the body to distally move a stopper in the body. The device may include a component configured to regulate distal movement of the plunger rod in a priming step and in a subsequent delivery step, so that the device may be accurately primed and may accurately dispense a predetermined volume of a drug substance.