Abstract: In various examples, techniques for determining perception zones for object detection are described. For instance, a system may use a dynamic model associated with an ego-machine, a dynamic model associated with an object, and one or more possible interactions between the ego-machine and the object to determine a perception zone. The system may then perform one or more processes using the perception zone. For instance, if the system is validating a perception system of the ego-machine, the system may determine whether a detection error associated with the object is a safety-critical error based on whether the object is located within the perception zone. Additionally, if the system is executing within the ego-machine, the system may determine whether the object is a safety-critical object based on whether the object is located within the perception zone.