Patents by Inventor Priyal Patel

Priyal Patel has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Lipid nanoparticles for delivering mRNA vaccines
    Patent number: 12239735
    Abstract: Provided are novel lipid nanoparticles for delivering nucleic acids such as mRNA. Also provided are methods of making and using lipid nanoparticles for delivering nucleic acids such as mRNA.
    Type: Grant
    Filed: November 7, 2023
    Date of Patent: March 4, 2025
    Assignee: SANOFI
    Inventors: Danilo Casimiro, Sudha Chivukula, Kirill Kalnin, Timothy Plitnik, Timothy Tibbitts, Frank Derosa, Anusha Dias, Rebecca L. Goldman, Hardip Rajeshbhai Gopani, Shrirang Karve, Asad Khanmohammed, Priyal Patel
  • STABLE COMPOSITIONS OF MRNA-LOADED LIPID NANOPARTICLES AND PROCESSES OF MAKING
    Publication number: 20250049954
    Abstract: The present invention provides an improved compositions and processes for preparing mRNA-loaded lipid nanoparticles (mRNA-LNPs). In some embodiments, the present invention provides mRNA-LNPs with exceptional stability and is particularly useful in cases where LNPs comprising low or no PEG-modified lipids are desired.
    Type: Application
    Filed: October 9, 2024
    Publication date: February 13, 2025
    Inventors: Shrirang KARVE, Frank DEROSA, Michael HEARTLEIN, Natalia VARGAS MONTOYA, Priyal PATEL, Ashish SARODE
  • PROCESS OF PREPARING MRNA-LOADED LIPID NANOPARTICLES
    Publication number: 20250025430
    Abstract: The present invention provides an improved process for lipid nanoparticle formulation and mRNA encapsulation. In some embodiments, the present invention provides a process of encapsulating messenger RNA (mRNA) in lipid nanoparticles comprising a step of combining a solution of preformed lipid nanoparticles with lipid nanoparticles encapsulating mRNA, resulting in a composition of increased potency of mRNA encoded protein expression in vivo.
    Type: Application
    Filed: June 25, 2024
    Publication date: January 23, 2025
    Inventors: Shrirang Karve, Frank DeRosa, Ashish Sarode, Natalia Vargas Montoya, Priyal Patel
  • Stable compositions of MRNA-loaded lipid nanoparticles and processes of making
    Patent number: 12144871
    Abstract: The present invention provides an improved compositions and processes for preparing mRNA-loaded lipid nanoparticles (mRNA-LNPs). In some embodiments, the present invention provides mRNA-LNPs with exceptional stability and is particularly useful in cases where LNPs comprising low or no PEG-modified lipids are desired.
    Type: Grant
    Filed: July 23, 2020
    Date of Patent: November 19, 2024
    Assignee: TRANSLATE BIO, INC.
    Inventors: Shrirang Karve, Frank DeRosa, Michael Heartlein, Natalia Vargas Montoya, Priyal Patel, Ashish Sarode
  • Process of preparing mRNA-loaded lipid nanoparticles
    Patent number: 12053551
    Abstract: The present invention provides an improved process for lipid nanoparticle formulation and mRNA encapsulation. In some embodiments, the present invention provides a process of encapsulating messenger RNA (mRNA) in lipid nanoparticles comprising a step of combining a solution of preformed lipid nanoparticles with lipid nanoparticles encapsulating mRNA, resulting in a composition of increased potency of mRNA encoded protein expression in vivo.
    Type: Grant
    Filed: December 21, 2020
    Date of Patent: August 6, 2024
    Assignee: TRANSLATE BIO, INC.
    Inventors: Shrirang Karve, Frank DeRosa, Ashish Sarode, Natalia Vargas Montoya, Priyal Patel
  • LIPID NANOPARTICLES FOR DELIVERING mRNA VACCINES
    Publication number: 20240148651
    Abstract: Provided are novel lipid nanoparticles for delivering nucleic acids such as mRNA. Also provided are methods of making and using lipid nanoparticles for delivering nucleic acids such as mRNA.
    Type: Application
    Filed: August 30, 2023
    Publication date: May 9, 2024
    Inventors: Danilo CASIMIRO, Sudha CHIVUKULA, Kirill KALNIN, Timothy PLITNIK, Timothy TIBBITTS, Angela Lynne BEAULIEU, Frank DEROSA, Anusha DIAS, Rebecca L. GOLDMAN, Hardip Rajeshbhai GOPANI, Shrirang KARVE, Asad KHANMOHAMMED, Natalia VARGAS MONTOYA, Priyal PATEL, Ashish L. SARODE, Khang Anh TRAN
  • LIPID NANOPARTICLES FOR DELIVERING mRNA VACCINES
    Publication number: 20240091154
    Abstract: Provided are novel lipid nanoparticles for delivering nucleic acids such as mRNA. Also provided are methods of making and using lipid nanoparticles for delivering nucleic acids such as mRNA.
    Type: Application
    Filed: November 7, 2023
    Publication date: March 21, 2024
    Inventors: Danilo CASIMIRO, Sudha CHIVUKULA, Kirill KALNIN, Timothy PLITNIK, Timothy TIBBITTS, Angela Lynne BEAULIEU, Frank DEROSA, Anusha DIAS, Rebecca L. GOLDMAN, Hardip Rajeshbhai GOPANI, Shrirang KARVE, Asad KHANMOHAMMED, Natalia VARGAS MONTOYA, Priyal PATEL, Ashish L. SARODE, Khang Anh TRAN
  • Lipid nanoparticles for delivering mRNA vaccines
    Patent number: 11771653
    Abstract: Provided are novel lipid nanoparticles for delivering nucleic acids such as mRNA. Also provided are methods of making and using lipid nanoparticles for delivering nucleic acids such as mRNA.
    Type: Grant
    Filed: June 30, 2022
    Date of Patent: October 3, 2023
    Assignee: SANOFI
    Inventors: Danilo Casimiro, Sudha Chivukula, Kirill Kalnin, Timothy Plitnik, Timothy Tibbitts, Frank Derosa, Anusha Dias, Rebecca L. Goldman, Hardip Rajeshbhai Gopani, Shrirang Karve, Asad Khanmohammed, Priyal Patel
  • Lipid nanoparticles for delivering mRNA vaccines
    Patent number: 11771652
    Abstract: Provided are novel lipid nanoparticles for delivering nucleic acids such as mRNA. Also provided are methods of making and using lipid nanoparticles for delivering nucleic acids such as mRNA.
    Type: Grant
    Filed: November 5, 2021
    Date of Patent: October 3, 2023
    Assignee: SANOFI
    Inventors: Danilo Casimiro, Sudha Chivukula, Kirill Kalnin, Timothy Plitnik, Timothy Tibbitts, Frank Derosa, Anusha Dias, Rebecca L. Goldman, Hardip Rajeshbhai Gopani, Shrirang Karve, Asad Khanmohammed, Priyal Patel
  • NANOPARTICLE COMPOSITIONS AND METHODS OF USE
    Publication number: 20230001009
    Abstract: Provided herein are compositions comprising a nanoparticle and a D20 tag. The D20 tag comprises dibenzocyclooctyne (DBCO) covalently attached to a protein. Also provided are diagnostic and therapeutic methods utilizing the nanoparticle composition.
    Type: Application
    Filed: December 3, 2020
    Publication date: January 5, 2023
    Inventors: Jacob Myerson, Jacob Brenner, Vladimir Muzykantov, Landis R. Walsh, Priyal Patel
  • LIPID NANOPARTICLES FOR DELIVERING mRNA VACCINES
    Publication number: 20220378701
    Abstract: Provided are novel lipid nanoparticles for delivering nucleic acids such as mRNA. Also provided are methods of making and using lipid nanoparticles for delivering nucleic acids such as mRNA.
    Type: Application
    Filed: June 30, 2022
    Publication date: December 1, 2022
    Inventors: Danilo CASIMIRO, Sudha CHIVUKULA, Kirill KALNIN, Timothy PLITNIK, Timothy TIBBITTS, Angela Lynne BEAULIEU, Frank DEROSA, Anusha DIAS, Rebecca L. GOLDMAN, Hardip Rajeshbhai GOPANI, Shrirang KARVE, Asad KHANMOHAMMED, Natalia VARGAS MONTOYA, Priyal PATEL, Ashish L. SARODE, Khang Anh TRAN
  • LIPID NANOPARTICLES FOR DELIVERING mRNA VACCINES
    Publication number: 20220347100
    Abstract: Provided are novel lipid nanoparticles for delivering nucleic acids such as mRNA. Also provided are methods of making and using lipid nanoparticles for delivering nucleic acids such as mRNA.
    Type: Application
    Filed: June 30, 2022
    Publication date: November 3, 2022
    Inventors: Danilo CASIMIRO, Sudha CHIVUKULA, Kirill KALNIN, Timothy PLITNIK, Timothy TIBBITTS, Angela Lynne BEAULIEU, Frank DEROSA, Anusha DIAS, Rebecca L. GOLDMAN, Hardip Rajeshbhai GOPANI, Shrirang KARVE, Asad KHANMOHAMMED, Natalia VARGAS MONTOYA, Priyal PATEL, Ashish L. SARODE, Khang Anh TRAN
  • Stable Liquid Lipid Nanoparticle Formulations
    Publication number: 20220287966
    Abstract: The present invention provides, among other things, a liquid lipid nanoparticle (LNP) formulation encapsulating mRNA encoding a peptide or polypeptide, that is resistant to aggregation and to mRNA degradation following multiple rounds of freezing at ?20° C. and rethawing.
    Type: Application
    Filed: November 24, 2021
    Publication date: September 15, 2022
    Inventors: Shrirang Karve, Ashish Sarode, Natalia Vargas Montoya, Priyal Patel, Frank DeRosa
  • IMPROVED PROCESS OF PREPARING MRNA-LOADED LIPID NANOPARTICLES
    Publication number: 20220218612
    Abstract: The present invention provides an improved process for lipid nanoparticle formulation and mRNA encapsulation. In some embodiments, the present invention provides a process for enhanced encapsulation of messenger RNA (mRNA) in lipid nanoparticles comprising a step of heating the mRNA-encapsulated lipid nanoparticles in a drug product formulation solution.
    Type: Application
    Filed: May 14, 2020
    Publication date: July 14, 2022
    Inventors: Shrirang Karve, Frank DeRosa, Michael Hearlein, Ashish Sarode, Zarna Patel, Rebecca L. Ball, Natalia Vargas Montoya, Priyal Patel, Asad Khanmohammed
  • LIPID NANOPARTICLES FOR DELIVERING mRNA VACCINES
    Publication number: 20220142923
    Abstract: Provided are novel lipid nanoparticles for delivering nucleic acids such as mRNA. Also provided are methods of making and using lipid nanoparticles for delivering nucleic acids such as mRNA.
    Type: Application
    Filed: November 5, 2021
    Publication date: May 12, 2022
    Inventors: Danilo CASIMIRO, Sudha CHIVUKULA, Kirill KALNIN, Timothy PLITNIK, Timothy TIBBITTS, Angela Lynne BEAULIEU, Frank DEROSA, Anusha DIAS, Rebecca L. GOLDMAN, Hardip Rajeshbhai GOPANI, Shrirang KARVE, Asad KHANMOHAMMED, Natalia VARGAS MONTOYA, Priyal PATEL, Ashish L. SARODE, Khang Anh TRAN
  • PUMPLESS ENCAPSULATION OF MESSENGER RNA
    Publication number: 20210378962
    Abstract: The present invention provides, among other things, a process of encapsulating messenger RNA (mRNA) in liposomes comprising a. providing a first stream comprising an mRNA solution at a first controlled flow rate, b. providing a second stream comprising a lipid solution at a second controlled flow rate, and c. mixing the first stream and the second stream to form mRNA-encapsulated liposomes, wherein the first controlled flow rate and the second controlled flow rate are achieved without use of a pump.
    Type: Application
    Filed: October 18, 2019
    Publication date: December 9, 2021
    Inventors: Shrirang Karve, Priyal Patel, Natalia Vargas Montoya, Frank DeRosa, Michael Heartlein
  • PROCESS OF PREPARING MRNA-LOADED LIPID NANOPARTICLES
    Publication number: 20210186890
    Abstract: The present invention provides an improved process for lipid nanoparticle formulation and mRNA encapsulation. In some embodiments, the present invention provides a process of encapsulating messenger RNA (mRNA) in lipid nanoparticles comprising a step of combining a solution of preformed lipid nanoparticles with lipid nanoparticles encapsulating mRNA, resulting in a composition of increased potency of mRNA encoded protein expression in vivo.
    Type: Application
    Filed: December 21, 2020
    Publication date: June 24, 2021
    Inventors: Shrirang Karve, Frank DeRosa, Ashish Sarode, Natalia Vargas Montoya, Priyal Patel
  • STABLE COMPOSITIONS OF MRNA-LOADED LIPID NANOPARTICLES AND PROCESSES OF MAKING
    Publication number: 20210046192
    Abstract: The present invention provides an improved compositions and processes for preparing mRNA-loaded lipid nanoparticles (mRNA-LNPs). In some embodiments, the present invention provides mRNA-LNPs with exceptional stability and is particularly useful in cases where LNPs comprising low or no PEG-modified lipids are desired.
    Type: Application
    Filed: July 23, 2020
    Publication date: February 18, 2021
    Inventors: Shrirang Karve, Frank DeRosa, Michael Heartlein, Natalia Vargas Montoya, Priyal Patel, Ashish Sarode