Patents by Inventor Priyanka Ghosh

Priyanka Ghosh has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Extending and maintaining micropore viability of microneedle treated skin with lipid biosynthesis inhibitors for sustained drug delivery
    Patent number: 10022366
    Abstract: Microneedles and their use as a physical skin permeation enhancement technique facilitate drug delivery across the skin in therapeutically relevant concentrations. Micropores created in the skin by MNs reseal because of normal healing processes of the skin, thus limiting the duration of the drug delivery window. Pore lifetime enhancement strategies can increase effectiveness of MNs as a drug delivery mechanism by prolonging the delivery window. Fluvastatin (FLU) was used to enhance pore lifetime by inhibiting the synthesis of cholesterol, a major component of the stratum corneum lipids. The skin recovered within a 30-45-min time period following the removal of occlusion, and there was no significant irritation observed due to the treatment compared to the control sites. Thus, it can be concluded that localized skin treatment with FLU can be used to extend micropore lifetime and deliver drugs for up to 7 days across MN-treated skin.
    Type: Grant
    Filed: April 23, 2014
    Date of Patent: July 17, 2018
    Assignees: University of Maryland, Baltimore, University of Kentucky Research Foundation
    Inventors: Audra L. Stinchcomb, Priyanka Ghosh
  • Compounds including Cox inhibitor moiety and enhanced delivery of active drugs using same
    Patent number: 9566341
    Abstract: The presently-disclosed subject matter includes compounds including a cyclooxygenase enzyme inhibitor moiety and a moiety derived from a drug of interest. In some embodiments, the drug of interest is an opioid. In some embodiments, the compound includes a diclofenac moiety and a naltrexone or naltrexol moiety. The compounds allow for enhanced delivery rates across skin.
    Type: Grant
    Filed: April 27, 2012
    Date of Patent: February 14, 2017
    Assignee: University of Kentucky Research Foundation
    Inventors: Audra Stinchcomb, Kyung Bo Kim, Ragotham Reddy Pinninti, Priyanka Ghosh, Kalpana S. Paudel
  • EXTENDING AND MAINTAINING MICROPORE VIABILITY OF MICRONEEDLE TREATED SKIN WITH LIPID BIOSYNTHESIS INHIBITORS FOR SUSTAINED DRUG DELIVERY
    Publication number: 20160074384
    Abstract: Microneedles and their use as a physical skin permeation enhancement technique facilitate drug delivery across the skin in therapeutically relevant concentrations. Micropores created in the skin by MNs reseal because of normal healing processes of the skin, thus limiting the duration of the drug delivery window. Pore lifetime enhancement strategies can increase effectiveness of MNs as a drug delivery mechanism by prolonging the delivery window. Fluvastatin (FLU) was used to enhance pore lifetime by inhibiting the synthesis of cholesterol, a major component of the stratum corneum lipids. The skin recovered within a 30-45-min time period following the removal of occlusion, and there was no significant irritation observed due to the treatment compared to the control sites. Thus, it can be concluded that localized skin treatment with FLU can be used to extend micropore lifetime and deliver drugs for up to 7 days across MN-treated skin.
    Type: Application
    Filed: April 23, 2014
    Publication date: March 17, 2016
    Applicants: University of Maryland, Baltimore, University of Kentucky Research Foundation
    Inventors: Audra L. Stinchcomb, Priyanka Ghosh