Abstract: The present invention relates to antibodies and fragments thereof that target semaphorin 3A (Sema3A). More specifically, anti-Sema3A antibodies and methods of use for the treatment of various diseases or disorders are disclosed.

Abstract: The present invention relates to new anti-PD-1 (Programmed cell death 1) antibodies and antigen-binding fragments thereof for therapeutic and diagnostic methods and compositions using them.

Abstract: A method of enhancing one or more fields of a master database record based on a consumption of one or more data points provided via a third-party data subscription service is disclosed. An aggregated view corresponding to a master database record is accessed. The aggregated view identifies correspondences between the one or more fields of the master database record and the one or more data points provided via the third-party data subscription service. Based on a determination that one or more consumption criteria are met, the one or more data points are consumed and stored in a central database. The one or more fields of the master database record are updated based on the one or more consumed data points. The enhanced master database record is provided via a network to one or more computerized processes associated with one or more consumers of the enhanced master database record.

Abstract: The present invention relates to novel anti-PD1 and anti-LAG3 antibody molecules. The invention also relates to nucleic acids encoding such antibody molecules; to methods for preparing such antibody molecules; to host cells expressing or capable of expressing such antibody molecules; to compositions comprising such antibody molecules; and to uses of such antibody molecules or such compositions, in particular for therapeutic purposes in the field of cancer diseases.

Abstract: The present invention relates to novel B7H6/CD3 binding proteins. The invention also relates to nucleic acids encoding such proteins; to methods for preparing such proteins; to host cells expressing or capable of expressing such proteins; to compositions comprising such proteins; and to uses of such proteins or such compositions, in particular for therapeutic purposes in the field of cancer diseases.

Abstract: A method of enhancing one or more fields of a master database record based on a consumption of one or more data points provided via a third-party data subscription service is disclosed. An aggregated view corresponding to a master database record is accessed. The aggregated view identifies correspondences between the one or more fields of the master database record and the one or more data points provided via the third-party data subscription service. Based on a determination that one or more consumption criteria are met, the one or more data points are consumed and stored in a central database. The one or more fields of the master database record are updated based on the one or more consumed data points. The enhanced master database record is provided via a network to one or more computerized processes associated with one or more consumers of the enhanced master database record.

Abstract: The present invention relates to novel anti-PD1 and anti-LAG3 antibody molecules. The invention also relates to nucleic acids encoding such antibody molecules; to methods for preparing such antibody molecules; to host cells expressing or capable of expressing such antibody molecules; to compositions comprising such antibody molecules; and to uses of such antibody molecules or such compositions, in particular for therapeutic purposes in the field of cancer diseases.

Abstract: The present disclosure relates to dynamically scheduling resource requests in a distributed system based on usage quotas. One example method includes identifying usage information for a distributed system including atoms, each atom representing a distinct item used by users of the distributed system; determining that a usage quota associated with the distributed system has been exceeded based on the usage information, the usage quota representing an upper limit for a particular type of usage of the distributed system; receiving a first request for a particular atom requiring invocation of the particular type of usage represented by the usage quota; determining that a second request for a different type of usage of the particular atom is waiting to be processed; and processing the second request for the particular atom before processing the first request.

Abstract: The present invention relates to antibodies and fragments thereof that target semaphorin 3A (Sema3A). More specifically, anti-Sema3A antibodies and methods of use for the treatment of various diseases or disorders are disclosed.

Abstract: A method of enhancing one or more fields of a master database record based on a consumption of one or more data points provided via a third-party data subscription service is disclosed. An aggregated view corresponding to a master database record is accessed. The aggregated view identifies correspondences between the one or more fields of the master database record and the one or more data points provided via the third-party data subscription service. Based on a determination that one or more consumption criteria are met, the one or more data points are consumed and stored in a central database. The one or more fields of the master database record are updated based on the one or more consumed data points. The enhanced master database record is provided via a network to one or more computerized processes associated with one or more consumers of the enhanced master database record.

Abstract: Traditional systems and methods have implemented hand-crafted feature extraction from varying length time series that results in complexity and requires domain knowledge. Building classification models requires large labeled data and is computationally expensive. Embodiments of the present disclosure implement learning models for classification tasks in multi-dimensional time series by performing feature extraction from entity's parameters via unsupervised encoder and build a non-temporal linear classifier model. A fixed-dimensional feature vector is outputted using a pre-trained unsupervised encoder, which acts as off-the shelf feature extractor. Extracted features are concatenated to learn a non-temporal linear classification model and weight is assigned to each extracted feature during learning which helps to determine relevant parameters for each class. Mapping from parameters to target class is considered while constraining the linear model to use only subset of large number of features.

Abstract: The present invention relates to novel DLL3/CD3 binding proteins. The invention also relates to nucleic acids encoding such proteins; to methods for preparing such proteins; to host cells expressing or capable of expressing such proteins; to compositions comprising such proteins; and to uses of such proteins or such compositions, in particular for therapeutic purposes in the field of cancer diseases.

Abstract: The present invention relates to novel antagonizing antibodies for CD73. The invention also relates to nucleic acids encoding such antibody molecules; to methods for preparing such antibody molecules; to host cells expressing or capable of expressing such antibody molecules; to compositions comprising such antibody molecules; and to uses of such antibody molecules or such compositions, in particular for therapeutic purposes in the field of cancer diseases.

Abstract: The present disclosure relates to dynamically scheduling resource requests in a distributed system based on usage quotas. One example method includes identifying usage information for a distributed system including atoms, each atom representing a distinct item used by users of the distributed system; determining that a usage quota associated with the distributed system has been exceeded based on the usage information, the usage quota representing an upper limit for a particular type of usage of the distributed system; receiving a first request for a particular atom requiring invocation of the particular type of usage represented by the usage quota; determining that a second request for a different type of usage of the particular atom is waiting to be processed; and processing the second request for the particular atom before processing the first request.

Abstract: The present invention relates to novel anti-PD1 and anti-LAG3 antibody molecules. The invention also relates to nucleic acids encoding such antibody molecules; to methods for preparing such antibody molecules; to host cells expressing or capable of expressing such antibody molecules; to compositions comprising such antibody molecules; and to uses of such antibody molecules or such compositions, in particular for therapeutic purposes in the field of cancer diseases.

Abstract: The present disclosure relates to dynamically scheduling resource requests in a distributed system based on usage quotas. One example method includes identifying usage information for a distributed system including atoms, each atom representing a distinct item used by users of the distributed system; determining that a usage quota associated with the distributed system has been exceeded based on the usage information, the usage quota representing an upper limit for a particular type of usage of the distributed system; receiving a first request for a particular atom requiring invocation of the particular type of usage represented by the usage quota; determining that a second request for a different type of usage of the particular atom is waiting to be processed; and processing the second request for the particular atom before processing the first request.

Abstract: A method and a system for enhancing routing in MultiProtocol Label Switching (MPLS) are provided. The method includes obtaining signaling protocol information from a plurality of routers and storing the signaling protocol information. Further, the method includes receiving a request from a router. The request includes a destination address, a signaling protocol and at least one other constraint. Further, the method also includes determining a Signaling Protocol specific Constrained based Explicit Route (SPCER) to the destination router from the signaling protocol information, and providing the SPCER to the router.