Abstract: Multispecific antigen-binding molecule capable of binding to multiple different antigens, but do not non-specifically crosslink two or more immune cells such as T cells are provided. Methods for producing or enriching a preferred structural form of such multispecific antibody protein, and method for eliminating disulfide heterogeneity of such multispecific antibody proteins are provided. In addition, conformation-specific antibodies that specifically recognize the preferred form of multispecific antibody proteins, and use of the conformation-specific antibodies are provided.

Abstract: An objective of the present invention is to provide a fusion protein that can activate its ligand moiety such as a cytokine or chemokine selectively in a target tissue. The present invention provides fusion proteins that include a ligand moiety such as a cytokine or chemokine connected via a peptide linker with a ligand-binding moiety that binds to the ligand moiety but is capable of releasing the ligand moiety in the presence of a protease. The present invention also provides their methods of production, their uses, and pharmaceutical compositions containing such a fusion protein. The present invention also relates to improved variants of such fusion proteins. Furthermore, for several cytokines, in vitro activities of the variants were evaluated.

Abstract: A client device can determine, based on global navigation satellite system (GNSS) data received from one or more GNSS satellites, a non-real-time kinematics (RTK) GNSS location of the client device. The client device can determine, based on corrections data received from a reference station, an RTK-assisted GNSS location, of the client device, from the non-RTK GNSS location. The client device can broadcast location information associated with the client device, the location information indicating the RTK-assisted GNSS location of the client device. The client device can receive, from a merchant device, a peer-to-peer connection request, for a peer-to-peer connection between the client device and the merchant device, based on transmitting the location information and based on the RTK-assisted GNSS location of the client device being located within a particular geographic area. The client device and the merchant device can process a transaction via the peer-to-peer connection.

Abstract: A client device can determine, based on global navigation satellite system (GNSS) data received from one or more GNSS satellites, a non-real-time kinematics (RTK) GNSS location of the client device. The client device can determine, based on corrections data received from a reference station, an RTK-assisted GNSS location, of the client device, from the non-RTK GNSS location. The client device can broadcast location information associated with the client device, the location information indicating the RTK-assisted GNSS location of the client device. The client device can receive, from a merchant device, a peer-to-peer connection request, for a peer-to-peer connection between the client device and the merchant device, based on transmitting the location information and based on the RTK-assisted GNSS location of the client device being located within a particular geographic area. The client device and the merchant device can process a transaction via the peer-to-peer connection.

Abstract: A system and method for facilitating client software access to messages, such as event messages, generated in a networked computing environment, such as a file-collaboration system. An example method uses a message bus and accompanying Application Programming Interfaces (APIs) to allow collaborators to employ client software to interface with highly scalable and organized message bus records, maintained via an underlying distributed database. The APIs and associated interface allow client software; not limited to collaboration software clients; to efficiently publish to, subscribe to, and obtain information about event records of the message bus. An embodiment allows selective load balancing and deferral of event message processing; efficient message offset handling and data center failover functionality, and so on.

Abstract: A system and method for facilitating client software access to messages, such as event messages, generated in a networked computing environment, such as a file-collaboration system. An example method uses a message bus and accompanying Application Programming Interfaces (APIs) to allow collaborators to employ client software to interface with highly scalable and organized message bus records, maintained via an underlying distributed database. The APIs and associated interface allow client software; not limited to collaboration software clients; to efficiently publish to, subscribe to, and obtain information about event records of the message bus. An embodiment allows selective load balancing and deferral of event message processing; efficient message offset handling and data center failover functionality, and so on.