Patents by Inventor Prometheus Laboratories Inc.

Prometheus Laboratories Inc. has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods of Predicting Methotrexate Efficacy and Toxicity
    Publication number: 20130143215
    Abstract: The present invention provides methods for analyzing genetic and/or metabolite biomarkers to individualize methotrexate (MTX) therapy. For example, the assay methods of the present invention are useful for predicting whether a patient will respond to MTX and/or has a risk of developing toxicity to MTX based upon the genotype of one or more folate pathway genes. The assay methods of the present invention are also useful for optimizing the dose of MTX in a patient already receiving the drug to achieve therapeutic efficacy and/or reduce toxic side-effects based upon the genotype of one or more folate pathway genes. In addition, the assay methods of the present invention are useful for predicting or optimizing the therapeutic response to MTX in a patient based upon the methotrexate polyglutamate and/or folate polyglutamate levels in a sample from the patient.
    Type: Application
    Filed: December 10, 2012
    Publication date: June 6, 2013
    Applicant: PROMETHEUS LABORATORIES INC.
    Inventor: Prometheus Laboratories Inc.