Patents by Inventor Pu Gao

Pu Gao has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Compositions and methods for altering second messenger signaling
    Patent number: 11014956
    Abstract: The present disclosure provides, among other things, compounds comprising cyclic dinucleotides containing a 2',5' linkage useful in the design of research tools, as research tools, and as therapeutic modalities such as enzyme modulators.
    Type: Grant
    Filed: June 28, 2019
    Date of Patent: May 25, 2021
    Assignees: Memorial Sloan Kettering Cancer Center; The Rockefeller, University; Rutgers, The State University of New Jersey, University of Bonn
    Inventors: Dinshaw J. Patel, Thomas Tuschl, Manuel Ascano, Jr., Yang Wu, Yizhou Liu, Winfried Barchet, Gunther Hartmann, Thomas Zillinger, Roger Jones, Barbara L. Gaffney, Pu Gao
  • COMPOSITIONS AND METHODS FOR ALTERING SECOND MESSENGER SIGNALING
    Publication number: 20190330257
    Abstract: The invention relates to compositions, methods, kits, and assays related to the use and/or exploitation of isomers of cGAMP as well as the structure of the enzyme cGAS.
    Type: Application
    Filed: June 28, 2019
    Publication date: October 31, 2019
    Inventors: Dinshaw J. Patel, Thomas Tuschl, Manuel Ascano, JR., Yang Wu, Yizhou Liu, Winfried Barchet, Gunther Hartmann, Thomas Zillinger, Roger Jones, Barbara L. Gaffney, Pu Gao
  • Compositions and methods for altering second messenger signaling
    Patent number: 10385091
    Abstract: The invention relates to compositions, methods, kits, and assays related to the use and/or exploitation of isomers of cGAMP as well as the structure of the enzyme cGAS.
    Type: Grant
    Filed: September 28, 2017
    Date of Patent: August 20, 2019
    Assignees: Memorial Sloan Kettering Cancer Center, The Rockefeller University, Rutgers, The State University of New Jersey, University of Bonn
    Inventors: Dinshaw J. Patel, Thomas Tuschl, Manuel Ascano, Jr., Yang Wu, Yizhou Liu, Winfried Barchet, Gunther Hartmann, Thomas Zillinger, Roger Jones, Barbara L. Gaffney, Pu Gao
  • STING crystals and modulators
    Patent number: 10176292
    Abstract: The present invention provides STING crystals. The present invention also provides STING modulators that interact with sites present in and/or defined by such crystals. The present invention also provides methods of making and using such crystals and modulators. Other aspects and/or features of the present invention will be apparent to those skilled in the art, reading the present specification.
    Type: Grant
    Filed: July 31, 2014
    Date of Patent: January 8, 2019
    Assignees: Memorial Sloan-Kettering Cancer Center, The Rockefeller University, Rutgers, The State University of New Jersey, University of Bonn
    Inventors: Dinshaw J. Patel, Thomas Tuschl, Roger Jones, Gunther Hartmann, Winfried Barchet, Thomas Zillinger, Weiyi Wang, Pu Gao, Liang Deng, Manuel Ascano, Jr.
  • Compositions and methods for altering second messenger signaling
    Patent number: 10131686
    Abstract: The invention relates to compositions, methods, kits, and assays related to the use and/or exploitation of isomers of cGAMP as well as the structure of the enzyme cGAS.
    Type: Grant
    Filed: December 8, 2017
    Date of Patent: November 20, 2018
    Assignees: Memorial Sloan Kettering Cancer Center, The Rockefeller University, Rutgers, The State University of New Jersey, University of Bonn
    Inventors: Dinshaw J. Patel, Thomas Tuschl, Manuel Ascano, Jr., Yang Wu, Yizhou Liu, Winfried Barchet, Gunther Hartmann, Thomas Zillinger, Roger Jones, Barbara L. Gaffney, Pu Gao
  • COMPOSITIONS AND METHODS FOR ALTERING SECOND MESSENGER SIGNALING
    Publication number: 20180127454
    Abstract: The invention relates to compositions, methods, kits, and assays related to the use and/or exploitation of isomers of cGAMP as well as the structure of the enzyme cGAS.
    Type: Application
    Filed: December 8, 2017
    Publication date: May 10, 2018
    Inventors: Dinshaw J. Patel, Thomas Tuschl, Manuel Ascano, Jr., Yang Wu, Yizhou Liu, Winfried Barchet, Gunther Hartmann, Thomas Zillinger, Roger Jones, Barbara L. Gaffney, Pu Gao
  • COMPOSITIONS AND METHODS FOR ALTERING SECOND MESSENGER SIGNALING
    Publication number: 20180118777
    Abstract: The invention relates to compositions, methods, kits, and assays related to the use and/or exploitation of isomers of cGAMP as well as the structure of the enzyme cGAS.
    Type: Application
    Filed: September 28, 2017
    Publication date: May 3, 2018
    Inventors: Dinshaw J. Patel, Thomas Tuschl, Manuel Ascano, Jr., Yang Wu, Yizhou Liu, Winfried Barchet, Gunther Hartmann, Thomas Zillinger, Roger Jones, Barbara L. Gaffney, Pu Gao
  • Compositions and methods for altering second messenger signaling
    Patent number: 9840533
    Abstract: The present disclosure provides, among other things, novel cyclic-GMP-AMP (cGAMP) analogs, mimics, mimetics and variants, and compositions and kits thereof; methods of using the compounds as described herein for treating cancer, and immune disease, disorders, or conditions; methods of using the compounds as described herein for modulating cGAS and STING; and methods of designing or characterizing a cGAS modulator.
    Type: Grant
    Filed: April 29, 2014
    Date of Patent: December 12, 2017
    Assignees: Memorial Sloan Kettering Cancer Center, Rutgers, The State University of New Jersey, The Rockefeller University, University of Bonn
    Inventors: Dinshaw Patel, Thomas Tuschl, Manuel Ascano, Jr., Yang Wu, Yizhou Liu, Winfried Barchet, Gunther Hartmann, Thomas Zillinger, Roger Jones, Barbara L. Gaffney, Pu Gao
  • STING CRYSTALS AND MODULATORS
    Publication number: 20160210400
    Abstract: The present invention provides STING crystals. The present invention also provides STING modulators that interact with sites present in and/or defined by such crystals. The present invention also provides methods of making and using such crystals and modulators. Other aspects and/or features of the present invention will be apparent to those skilled in the art, reading the present specification.
    Type: Application
    Filed: July 31, 2014
    Publication date: July 21, 2016
    Inventors: Dinshaw J. Patel, Thomas Tuschl, Roger Jones, Gunther Hartmann, Winfried Barchet, Thomas Zillinger, Weiyi Wang, Pu Gao, Liang Deng, Manuel Ascano, JR.
  • COMPOSITIONS AND METHODS FOR ALTERING SECOND MESSENGER SIGNALING
    Publication number: 20160068560
    Abstract: The invention relates to compositions, methods, kits, and assays related to the use and/or exploitation of isomers of cGAMP as well as the structure of the enzyme cGAS.
    Type: Application
    Filed: April 29, 2014
    Publication date: March 10, 2016
    Applicant: Memorial Sloan Kettering Cancer Center
    Inventors: Dinshaw Patel, Thomas Tuschl, Manuel Ascano, JR., Yang Wu, Yizhou Liu, Winfried Barchet, Gunther Hartmann, Thomas Zillinger, Roger Jones, Barbara L. Gaffney, Pu Gao
  • Apparatus and method for handwriting recognition
    Patent number: 8094938
    Abstract: An apparatus (100) for handwriting recognition has a touch-sensitive display screen (240) providing a hand writing input area (270) capable of detecting hand-made user input. The apparatus also has a processing device (300) coupled to the touch-sensitive display screen and providing a user interface to a user. The handwriting input area (270) includes a writing start area (280) capable of switching between a first two-dimensional scope (282) and a second two-dimensional scope (282?), larger than the first two-dimensional scope. The processing device (300) is configured to handle said handmade user input as either a logical mouse event, associated with a control operation for said user interface, or a logical pen event, associated with handwriting.
    Type: Grant
    Filed: April 2, 2004
    Date of Patent: January 10, 2012
    Assignee: Nokia Corporation
    Inventors: Kong Qiao Wang, Ying Liu, Yanming Zou, Yi pu Gao, Jari A. Kangas
  • Apparatus and Method for Handwriting Recognition
    Publication number: 20080166049
    Abstract: An apparatus (100) for handwriting recognition has a touch-sensitive display screen (240) providing a hand writing input area (270) capable of detecting hand-made user input. The apparatus also has a processing device (300) coupled to the touch-sensitive display screen and providing a user interface to a user. The handwriting input area (270) includes a writing start area (280) capable of switching between a first two-dimensional scope (282) and a second two-dimensional scope (282?), larger than the first two-dimensional scope. The processing device (300) is configured to handle said handmade user input as either a logical mouse event, associated with a control operation for said user interface, or a logical pen event, associated with handwriting.
    Type: Application
    Filed: April 2, 2004
    Publication date: July 10, 2008
    Applicant: NOKIA CORPORATION
    Inventors: Kong Qiao Wang, Ying Liu, Yanming Zou, Yi pu Gao, Jari A. Kangas
  • NANOSCALE JUNCTION ARRAYS AND METHODS FOR MAKING SAME
    Publication number: 20060254501
    Abstract: A nanoscale junction array includes an elongated nanowire and a plurality of elongated nanobelts. Each nanobelt has a proximal end and an opposite distal end. The proximal end of each nanobelt is attached to a different location on the nanowire. Each nanobelt extends radially away from the nanowire. A type of nanoscale junction array, a nanopropeller, includes an elongated nanowire and a plurality of elongated nanoblades. The nanoscale junction array is formed from Zinc Oxide using a metal vaporization process.
    Type: Application
    Filed: December 2, 2003
    Publication date: November 16, 2006
    Inventors: Zhong Wang, Pu Gao